中文别名:
长春质碱;酒石酸长春质碱;瀉花鹼;(+)-长春碱;泻花碱;长春质碱(标准品);长春质碱对照品,;长春质碱, 来源于长春花
英文别名:
(+)-3,4-didehydrocoronaridine;18-beta)-lph;catharanthin;ibogamine-18-carboxylicacid,3,4-didehydro-,methylester,(2-alpha,5-beta,6-a;7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester;Catharanthine, 98%, from Catharanthus roseus (L.) G. Don;4-Didehydrocoronaridine;methyl(2-alpha,5-beta,6-alpha,18-beta)-3,4-didehydroibogamine-18-carboxylate
InChI:
InChI=1/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
密度:
1.1367 (rough estimate)
沸点:
472.9°C (rough estimate)
物化性质:
白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于长春花。
产品用途:
抑制烟碱受体介导的膈肌收缩,IC50:59.6μM。Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.