氟氧头孢

氟氧头孢

(-)-(6R,7R)-7-(2-((二氟甲基)硫)乙酰氨基)-3-(((1-(2-羟乙基)-1H-四唑-5-基)硫)甲基)-7-甲氧基-8-氧代-5-氧杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸;氟氧头孢;(6R-CIS)-7-[[[(二氟甲基)硫基]乙酰基]氨基]-3-[[[1-(2-羟基乙基)-1H-四氮唑-5-基]硫基]甲基]-7-甲氧基-8-氧代-5-氧杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸;氟莫头孢;氟氧头孢酸

Flomoxef

FLOMOXEF;5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-;FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ];5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-;Flumarin;FMOX;(-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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C15H18F2N6O7S2

496.47

InChI=1/C15H18F2N6O7S2/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27)/t12-,15+/m1/s1

1.85±0.1 g/cm3(Predicted)

-82.5-87.5°

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从丙酮-二氯甲烷中结晶，熔点82.5～87.5℃。

对各种革兰阳性和阴性菌均有极好的抗菌活性。用于金黄色葡菌、链球菌、大肠杆菌、流感杆菌等其它敏感菌所引起的败血症、心内膜炎、咽喉炎、急慢性支气管炎、慢性呼吸道疾病的继发感染、肺炎、胆道炎、胆囊炎、子宫内膜炎等。

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