Name:
Thromboplastin-D
Synonym:
None
CAS:
0-01-1
Section 1 - Chemical Product
MSDS Name:Thromboplastin-D
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 0-01-1 | HEPES | 0.50% | 230-907-9 |
| Hazard Symbols: None Listed. Risk Phrases: None Listed. |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool place in the original container and protect from sunlight. Keep container closed when not in use.
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool place in the original container and protect from sunlight. Keep container closed when not in use.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Good general ventilation should be sufficient to control airborne levels. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 0-01-1: CAS# 7365-45-9: CAS# 7647-14-5: Russia: 5 mg/m3 TWA CAS# 9002-92-0: CAS# 9048-46-1: CAS# 10043-52-4: CAS# 25322-68-3: Germany: 1000 mg/m3 TWA (inhalable fraction) Netherlands: 1000 mg/m3 MAC CAS# 26628-22-8: United Kingdom, WEL - TWA: 0.1 mg/m3 TWA (as NaN3) United Kingdom, WEL - STEL: 0.3 mg/m3 STEL (as NaN3) Belgium - TWA: 0.1 mg/m3 VLE Belgium - STEL: 0.30 mg/m3 VLE France - VLE: 0.1 ppm VLE; 0.3 mg/m3 VLE Germany: 0.2 mg/m3 TWA Malaysia: 0.29 mg/m3 Ceiling (as sodium azide); 0.11 ppm Ceiling hydrazoic acid vapour Netherlands: 0.3 mg/m3 STEL Netherlands: 0.1 mg/m3 MAC Spain: 0.1 mg/m3 VLA-ED Spain: 0.3 mg/m3 VLA-EC; 0.1 ppm VLA-EC (as hydrazoic acid vapor) 0.18 mg/m3 VLA-EC (a Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Good general ventilation should be sufficient to control airborne levels. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 0-01-1: CAS# 7365-45-9: CAS# 7647-14-5: Russia: 5 mg/m3 TWA CAS# 9002-92-0: CAS# 9048-46-1: CAS# 10043-52-4: CAS# 25322-68-3: Germany: 1000 mg/m3 TWA (inhalable fraction) Netherlands: 1000 mg/m3 MAC CAS# 26628-22-8: United Kingdom, WEL - TWA: 0.1 mg/m3 TWA (as NaN3) United Kingdom, WEL - STEL: 0.3 mg/m3 STEL (as NaN3) Belgium - TWA: 0.1 mg/m3 VLE Belgium - STEL: 0.30 mg/m3 VLE France - VLE: 0.1 ppm VLE; 0.3 mg/m3 VLE Germany: 0.2 mg/m3 TWA Malaysia: 0.29 mg/m3 Ceiling (as sodium azide); 0.11 ppm Ceiling hydrazoic acid vapour Netherlands: 0.3 mg/m3 STEL Netherlands: 0.1 mg/m3 MAC Spain: 0.1 mg/m3 VLA-ED Spain: 0.3 mg/m3 VLA-EC; 0.1 ppm VLA-EC (as hydrazoic acid vapor) 0.18 mg/m3 VLA-EC (a Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: white
Odor: Odorless.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: Not applicable.
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials.
Incompatibilities with Other Materials:
Strong oxidants.
Hazardous Decomposition Products:
No data available.
Hazardous Polymerization: Has not been reported
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials.
Incompatibilities with Other Materials:
Strong oxidants.
Hazardous Decomposition Products:
No data available.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 0-01-1 unlisted.
CAS# 7365-45-9: TL6809000 CAS# 7647-14-5: VZ4725000 CAS# 9002-92-0: JR5960000 JR5970000 JR5990000 MD0875000 CAS# 9048-46-1 unlisted.
CAS# 10043-52-4: EV9800000 CAS# 25322-68-3: TQ3500000 TQ3520000 TQ3560000 TQ3580000 TQ3600000 TQ3610000 TQ3620000 TQ3630000 TQ3650000 TQ3675000 TQ3700000 TQ3800000 TQ3850000 TQ4025000 TQ4026000 TQ4027000 TQ4028000 TQ4030000 TQ4040000 TQ4041000 TQ4050000 TQ4070000 TQ4100000 TQ4105000 TQ4110000 TQ4950000 TQ5090000 TR1579850 ZD2465300 CAS# 26628-22-8: VY8050000 LD50/LC50:
Not available.
Not available.
CAS# 7647-14-5: Draize test, rabbit, eye: 100 mg Mild; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, skin: 50 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = >42 gm/m3/1H; Oral, mouse: LD50 = 4 gm/kg; Oral, rat: LD50 = 3000 mg/kg; Skin, rabbit: LD50 = >10 gm/kg.
CAS# 9002-92-0: Draize test, rabbit, eye: 10 mg; Draize test, rabbit, eye: 100 mg; Draize test, rabbit, eye: 750 ug/24H Severe; Draize test, rabbit, skin: 100 mg; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 75 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, mouse: LD50 = 4940 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, mouse: LD50 = 3500 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 4150 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 1 gm/kg.
CAS# 9048-46-1.
CAS# 10043-52-4: Oral, mouse: LD50 = 1940 mg/kg; Oral, rabbit: LD50 = 1384 mg/kg; Oral, rat: LD50 = 1 gm/kg.
CAS# 25322-68-3: Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 100 uL Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg Mild; Oral, mouse: LD50 = 34 gm/kg; Oral, mouse: LD50 = 31 gm/kg; Oral, mouse: LD50 = 28915 mg/kg; Oral, mouse: LD50 = 36 gm/kg; Oral, rabbit: LD50 = 17300 mg/kg; Oral, rabbit: LD50 = 76 gm/kg; Oral, rabbit: LD50 = 14 gm/kg; Oral, rabbit: LD50 = 17300 mg/kg; Oral, rabbit: LD50 = 26800 mg/kg; Oral, rabbit: LD50 = 19 gm/kg; Oral, rabbit: LD50 = 28900 mg/kg; Oral, rabbit: LD50 = 76 gm/kg; Oral, rat: LD50 = 28 gm/kg; Oral, rat: LD50 = 31640 mg/kg; CAS# 26628-22-8: Inhalation, mouse: LC50 = 32400 ug/m3; Inhalation, rat: LC50 = 37 mg/m3; Oral, mouse: LD50 = 27 mg/kg; Oral, rat: LD50 = 27 mg/kg; Skin, rabbit: LD50 = 20 mg/kg; Skin, rat: LD50 = 50 mg/kg.
Carcinogenicity:
Rabbit Brain Extract - Not listed by ACGIH, IARC, or NTP.
HEPES - Not listed by ACGIH, IARC, or NTP.
Sodium chloride - Not listed by ACGIH, IARC, or NTP.
Brij-35 - Not listed by ACGIH, IARC, or NTP.
BSA Fraction V - Not listed by ACGIH, IARC, or NTP.
Calcium chloride - Not listed by ACGIH, IARC, or NTP.
Polyethylene glycol - Not listed by ACGIH, IARC, or NTP.
Sodium azide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 0-01-1 unlisted.
CAS# 7365-45-9: TL6809000 CAS# 7647-14-5: VZ4725000 CAS# 9002-92-0: JR5960000 JR5970000 JR5990000 MD0875000 CAS# 9048-46-1 unlisted.
CAS# 10043-52-4: EV9800000 CAS# 25322-68-3: TQ3500000 TQ3520000 TQ3560000 TQ3580000 TQ3600000 TQ3610000 TQ3620000 TQ3630000 TQ3650000 TQ3675000 TQ3700000 TQ3800000 TQ3850000 TQ4025000 TQ4026000 TQ4027000 TQ4028000 TQ4030000 TQ4040000 TQ4041000 TQ4050000 TQ4070000 TQ4100000 TQ4105000 TQ4110000 TQ4950000 TQ5090000 TR1579850 ZD2465300 CAS# 26628-22-8: VY8050000 LD50/LC50:
Not available.
Not available.
CAS# 7647-14-5: Draize test, rabbit, eye: 100 mg Mild; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, skin: 50 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = >42 gm/m3/1H; Oral, mouse: LD50 = 4 gm/kg; Oral, rat: LD50 = 3000 mg/kg; Skin, rabbit: LD50 = >10 gm/kg.
CAS# 9002-92-0: Draize test, rabbit, eye: 10 mg; Draize test, rabbit, eye: 100 mg; Draize test, rabbit, eye: 750 ug/24H Severe; Draize test, rabbit, skin: 100 mg; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 75 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, mouse: LD50 = 4940 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, mouse: LD50 = 3500 mg/kg; Oral, mouse: LD50 = 1170 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 4150 mg/kg; Oral, rat: LD50 = 8600 mg/kg; Oral, rat: LD50 = 1 gm/kg.
CAS# 9048-46-1.
CAS# 10043-52-4: Oral, mouse: LD50 = 1940 mg/kg; Oral, rabbit: LD50 = 1384 mg/kg; Oral, rat: LD50 = 1 gm/kg.
CAS# 25322-68-3: Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 100 uL Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, eye: 500 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg Mild; Oral, mouse: LD50 = 34 gm/kg; Oral, mouse: LD50 = 31 gm/kg; Oral, mouse: LD50 = 28915 mg/kg; Oral, mouse: LD50 = 36 gm/kg; Oral, rabbit: LD50 = 17300 mg/kg; Oral, rabbit: LD50 = 76 gm/kg; Oral, rabbit: LD50 = 14 gm/kg; Oral, rabbit: LD50 = 17300 mg/kg; Oral, rabbit: LD50 = 26800 mg/kg; Oral, rabbit: LD50 = 19 gm/kg; Oral, rabbit: LD50 = 28900 mg/kg; Oral, rabbit: LD50 = 76 gm/kg; Oral, rat: LD50 = 28 gm/kg; Oral, rat: LD50 = 31640 mg/kg; CAS# 26628-22-8: Inhalation, mouse: LC50 = 32400 ug/m3; Inhalation, rat: LC50 = 37 mg/m3; Oral, mouse: LD50 = 27 mg/kg; Oral, rat: LD50 = 27 mg/kg; Skin, rabbit: LD50 = 20 mg/kg; Skin, rat: LD50 = 50 mg/kg.
Carcinogenicity:
Rabbit Brain Extract - Not listed by ACGIH, IARC, or NTP.
HEPES - Not listed by ACGIH, IARC, or NTP.
Sodium chloride - Not listed by ACGIH, IARC, or NTP.
Brij-35 - Not listed by ACGIH, IARC, or NTP.
BSA Fraction V - Not listed by ACGIH, IARC, or NTP.
Calcium chloride - Not listed by ACGIH, IARC, or NTP.
Polyethylene glycol - Not listed by ACGIH, IARC, or NTP.
Sodium azide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III
USA RQ: CAS# 26628-22-8: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 0-01-1: No information available.
CAS# 7365-45-9: No information available.
CAS# 7647-14-5: 0
CAS# 9002-92-0: 2
CAS# 9048-46-1: No information available.
CAS# 10043-52-4: 0
CAS# 25322-68-3: 1
CAS# 26628-22-8: 2
Canada
CAS# 7365-45-9 is listed on Canadas DSL List.
CAS# 7647-14-5 is listed on Canadas DSL List.
CAS# 9002-92-0 is listed on Canadas DSL List.
CAS# 10043-52-4 is listed on Canadas DSL List.
CAS# 25322-68-3 is listed on Canadas DSL List.
CAS# 26628-22-8 is listed on Canadas DSL List.
CAS# 0-01-1 is not listed on Canadas Ingredient Disclosure List.
CAS# 7365-45-9 is not listed on Canadas Ingredient Disclosure List.
CAS# 7647-14-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 9002-92-0 is listed on Canadas Ingredient Disclosure List.
CAS# 9048-46-1 is not listed on Canadas Ingredient Disclosure List.
CAS# 10043-52-4 is not listed on Canadas Ingredient Disclosure List.
CAS# 25322-68-3 is not listed on Canadas Ingredient Disclosure List.
CAS# 26628-22-8 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 0-01-1 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 7365-45-9 is listed on the TSCA inventory.
CAS# 7647-14-5 is listed on the TSCA inventory.
CAS# 9002-92-0 is listed on the TSCA inventory.
CAS# 9048-46-1 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 10043-52-4 is listed on the TSCA inventory.
CAS# 25322-68-3 is listed on the TSCA inventory.
CAS# 26628-22-8 is listed on the TSCA inventory.
