Name:
Toluene-d8
Synonym:
Methylbenzene; Methylbenzol; Phenylmethane; Toluol
CAS:
108-88-3
Section 1 - Chemical Product
MSDS Name:Toluene-d8
Synonym:Methylbenzene; Methylbenzol; Phenylmethane; Toluol
Synonym:Methylbenzene; Methylbenzol; Phenylmethane; Toluol
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 108-88-3 | Toluene-d8 | >99 | 218-009-5 |
| Hazard Symbols: XN F Risk Phrases: 11 38 48/20 63 65 67 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Irritating to skin. Harmful : danger of serious damage to health by prolonged exposure through inhalation. Possible risk of harm to the unborn child. Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin. Not expected to cause an allergic skin reaction.
Ingestion:
May cause effects similar to those for inhalation exposure.
Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause central nervous system depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of high concentrations (>200 ppm) of toluene are clearly associated with CNS encephalopathy, headache, depression, lassitude (weakness, exhaustion), impaired coordination, transient memory loss, and impaired reaction time.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Repeated exposure in combination with constant, loud noise can produce hearing loss and dizziness. Chronic hydrocarbon abuse (for example, sniffing glue or light hydrocarbons such as contained in this material) has been associated with irregular heart rhythms and potential cardiac arrest. Toluene abuse has been linked with kidney disease, as evidenced by blood, protein, & pus in the urine, accompanied by elevated serum creatinine, decreased urinary output, & metabolic & renal tubular acidosis. Although kidney toxicity has not been common in cases of occupational toluene exposure, there has been at least one report of renal toxicity following a 40-year occupational toluene exposure. Toluene does not cause the severe injury to the bone marrow that is characteristic of benzene poisoning.
Highly flammable. Irritating to skin. Harmful : danger of serious damage to health by prolonged exposure through inhalation. Possible risk of harm to the unborn child. Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin. Not expected to cause an allergic skin reaction.
Ingestion:
May cause effects similar to those for inhalation exposure.
Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause central nervous system depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of high concentrations (>200 ppm) of toluene are clearly associated with CNS encephalopathy, headache, depression, lassitude (weakness, exhaustion), impaired coordination, transient memory loss, and impaired reaction time.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Repeated exposure in combination with constant, loud noise can produce hearing loss and dizziness. Chronic hydrocarbon abuse (for example, sniffing glue or light hydrocarbons such as contained in this material) has been associated with irregular heart rhythms and potential cardiac arrest. Toluene abuse has been linked with kidney disease, as evidenced by blood, protein, & pus in the urine, accompanied by elevated serum creatinine, decreased urinary output, & metabolic & renal tubular acidosis. Although kidney toxicity has not been common in cases of occupational toluene exposure, there has been at least one report of renal toxicity following a 40-year occupational toluene exposure. Toluene does not cause the severe injury to the bone marrow that is characteristic of benzene poisoning.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. This liquid floats on water and may travel to a source of ignition and spread fire. May accumulate static electricity.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Solid streams of water may be ineffective and spread material.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. This liquid floats on water and may travel to a source of ignition and spread fire. May accumulate static electricity.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Solid streams of water may be ineffective and spread material.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Provide ventilation. Use only non-sparking tools and equipment.
Control runoff and isolate discharged material for proper disposal.
Use water spray to cool and disperse vapors and protect personnel.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Provide ventilation. Use only non-sparking tools and equipment.
Control runoff and isolate discharged material for proper disposal.
Use water spray to cool and disperse vapors and protect personnel.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Separate from oxidizing materials.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Keep away from heat, sparks and flame. Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Separate from oxidizing materials.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 108-88-3: United Kingdom, WEL - TWA: 50 ppm TWA; 191 mg/m3 TWA United Kingdom, WEL - STEL: 150 ppm STEL; 574 mg/m3 STEL United States OSHA: 200 ppm TWA; 300 ppm Ceiling Belgium - TWA: 50 ppm VLE; 191 mg/m3 VLE France - VME: 100 ppm VME; 375 mg/m3 VME France - VLE: 150 ppm VLE; 550 mg/m3 VLE Germany: 50 ppm TWA; 190 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 188 mg/m3 OEL Malaysia: 50 ppm TWA; 188 mg/m3 TWA Netherlands: 40 ppm MAC; 150 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 50 ppm VLA-ED; 191 mg/m3 VLA-ED CAS# 2037-26-5: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 108-88-3: United Kingdom, WEL - TWA: 50 ppm TWA; 191 mg/m3 TWA United Kingdom, WEL - STEL: 150 ppm STEL; 574 mg/m3 STEL United States OSHA: 200 ppm TWA; 300 ppm Ceiling Belgium - TWA: 50 ppm VLE; 191 mg/m3 VLE France - VME: 100 ppm VME; 375 mg/m3 VME France - VLE: 150 ppm VLE; 550 mg/m3 VLE Germany: 50 ppm TWA; 190 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 188 mg/m3 OEL Malaysia: 50 ppm TWA; 188 mg/m3 TWA Netherlands: 40 ppm MAC; 150 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 50 ppm VLA-ED; 191 mg/m3 VLA-ED CAS# 2037-26-5: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: sweetish odor - pleasant odor - benzene-like
pH: Not applicable.
Vapor Pressure: 28.4 mm Hg @ 25 deg C
Viscosity: 0.59 cps @ 20 deg C
Boiling Point: 110 deg C
Freezing/Melting Point: -84 deg C
Autoignition Temperature: 480 deg C ( 896.00 deg F)
Flash Point: 4 deg C ( 39.20 deg F)
Explosion Limits, lower: 1.1 vol%
Explosion Limits, upper: 7.1 vol%
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 0.94 (Water=1)
Molecular Formula: C7D8
Molecular Weight: 100.19
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, nitric acid, sulfuric acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, nitric acid, sulfuric acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 108-88-3: XS5250000 CAS# 2037-26-5 unlisted.
LD50/LC50:
CAS# 108-88-3: Draize test, rabbit, eye: 870 ug Mild; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 435 mg Mild; Draize test, rabbit, skin: 500 mg Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 400 ppm/24H; Inhalation, mouse: LC50 = 30000 mg/m3/2H; Inhalation, mouse: LC50 = 19900 mg/m3/7H; Inhalation, mouse: LC50 = 10000 mg/m3; Inhalation, rat: LC50 = 49 gm/m3/4H; Oral, rat: LD50 = 636 mg/kg; Skin, rabbit: LD50 = 14100 uL/kg.
CAS# 2037-26-5.
Carcinogenicity:
Toluene - Not listed by ACGIH, IARC, or NTP.
Toluene-d8 - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 108-88-3: XS5250000 CAS# 2037-26-5 unlisted.
LD50/LC50:
CAS# 108-88-3: Draize test, rabbit, eye: 870 ug Mild; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 435 mg Mild; Draize test, rabbit, skin: 500 mg Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 400 ppm/24H; Inhalation, mouse: LC50 = 30000 mg/m3/2H; Inhalation, mouse: LC50 = 19900 mg/m3/7H; Inhalation, mouse: LC50 = 10000 mg/m3; Inhalation, rat: LC50 = 49 gm/m3/4H; Oral, rat: LD50 = 636 mg/kg; Skin, rabbit: LD50 = 14100 uL/kg.
CAS# 2037-26-5.
Carcinogenicity:
Toluene - Not listed by ACGIH, IARC, or NTP.
Toluene-d8 - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Bluegill LC50=17 mg/L/24H Shrimp LC50=4.3 ppm/96H Fathead minnow LC50=36.2 mg/L/96H Sunfish (fresh water) TLm=1180 mg/L/96H
Bluegill LC50=17 mg/L/24H Shrimp LC50=4.3 ppm/96H Fathead minnow LC50=36.2 mg/L/96H Sunfish (fresh water) TLm=1180 mg/L/96H
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: TOLUENE
Hazard Class: 3
UN Number: 1294
Packing Group: II
IMO
Shipping Name: TOLUENE
Hazard Class: 3
UN Number: 1294
Packing Group: II
RID/ADR
Shipping Name: TOLUENE
Hazard Class: 3
UN Number: 1294
Packing group: II
USA RQ: CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 38 Irritating to skin.
R 48/20 Harmful : danger of serious damage to health
by prolonged exposure through inhalation.
R 63 Possible risk of harm to the unborn child.
R 65 Harmful: may cause lung damage if swallowed.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
S 62 If swallowed, do not induce vomiting: seek
medical advice immediately and show this container or
label.
WGK (Water Danger/Protection)
CAS# 108-88-3: 2
CAS# 2037-26-5: No information available.
Canada
CAS# 108-88-3 is listed on Canadas DSL List.
CAS# 108-88-3 is listed on Canadas Ingredient Disclosure List.
CAS# 2037-26-5 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 108-88-3 is listed on the TSCA inventory.
CAS# 2037-26-5 is not listed on the TSCA inventory.
It is for research and development use only.
