Name:
Trimethylamine 25% in methanol
Synonym:
CAS:
65-55-0
Section 1 - Chemical Product
MSDS Name:Trimethylamine 25% in methanol
Synonym:
Synonym:
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 65-55-0 | Trimethylamine | 25 | 200-875-0 |
| Hazard Symbols: T F Risk Phrases: 11 23/25 36/37 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Toxic by inhalation and if swallowed. Irritating to eyes and respiratory system.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation. Contact may cause ulceration of the conjunctiva and cornea. May cause painful sensitization to light.
Skin:
Prolonged and/or repeated contact may cause irritation and/or dermatitis. May cause severe irritation and possible burns.
Ingestion:
May be fatal or cause blindness if swallowed. May cause systemic toxicity with acidosis. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
May cause liver and kidney damage. May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. May cause effects similar to those described for ingestion. May cause narcotic effects in high concentration. May cause drowsiness, unconsciousness, and central nervous system depression.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Repeated exposure may cause allergic respiratory reaction (asthma).
Highly flammable. Toxic by inhalation and if swallowed. Irritating to eyes and respiratory system.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation. Contact may cause ulceration of the conjunctiva and cornea. May cause painful sensitization to light.
Skin:
Prolonged and/or repeated contact may cause irritation and/or dermatitis. May cause severe irritation and possible burns.
Ingestion:
May be fatal or cause blindness if swallowed. May cause systemic toxicity with acidosis. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
May cause liver and kidney damage. May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. May cause effects similar to those described for ingestion. May cause narcotic effects in high concentration. May cause drowsiness, unconsciousness, and central nervous system depression.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Repeated exposure may cause allergic respiratory reaction (asthma).
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Flammable Liquid.
Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Flammable Liquid.
Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 65-55-0: CAS# 75-50-3: Belgium - TWA: 5 ppm VLE; 12 mg/m3 VLE Belgium - STEL: 15 ppm VLE; 37 mg/m3 VLE France - VLE: 10 ppm VLE; 25 mg/m3 VLE Malaysia: 5 ppm TWA; 12 mg/m3 TWA Netherlands: 0.4 ppm MAC; 1 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 12 mg/m3 VLA-ED Spain: 15 ppm VLA-EC; 37 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 65-55-0: CAS# 75-50-3: Belgium - TWA: 5 ppm VLE; 12 mg/m3 VLE Belgium - STEL: 15 ppm VLE; 37 mg/m3 VLE France - VLE: 10 ppm VLE; 25 mg/m3 VLE Malaysia: 5 ppm TWA; 12 mg/m3 TWA Netherlands: 0.4 ppm MAC; 1 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 12 mg/m3 VLA-ED Spain: 15 ppm VLA-EC; 37 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 52 deg F ( 11.11 deg C)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, temperatures above 200C.
Incompatibilities with Other Materials:
Incompatibilities with methanol include: oxidants, active metals, acetyl bromide, alkyl aluminum salts, beryllium dihydride, carbon tetrachloride + metals, chloroform + heat, chloroform + sodium hydroxide, cyanuric chloride, diethyl zinc, nitric acid and potassium tertbutoxide. Incompatibilities with trimethylamine include: acids, acid chlorides, acid anhydrides, copper, brass, strong oxidizing agents, heat, mercury, nitrates, permanganates, nitric acid, halogens, and peroxides. Potentially explosive reactions can occur between trimethylamine and bromine + heat; ethylene oxide; triethynylaluminum. Please refer to the NFPA Fire Protection guide for the specific details.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, formaldehyde, ammonia.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, temperatures above 200C.
Incompatibilities with Other Materials:
Incompatibilities with methanol include: oxidants, active metals, acetyl bromide, alkyl aluminum salts, beryllium dihydride, carbon tetrachloride + metals, chloroform + heat, chloroform + sodium hydroxide, cyanuric chloride, diethyl zinc, nitric acid and potassium tertbutoxide. Incompatibilities with trimethylamine include: acids, acid chlorides, acid anhydrides, copper, brass, strong oxidizing agents, heat, mercury, nitrates, permanganates, nitric acid, halogens, and peroxides. Potentially explosive reactions can occur between trimethylamine and bromine + heat; ethylene oxide; triethynylaluminum. Please refer to the NFPA Fire Protection guide for the specific details.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, formaldehyde, ammonia.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 65-55-0 unlisted.
CAS# 75-50-3: PA0350000 LD50/LC50:
Not available.
CAS# 75-50-3: Inhalation, mouse: LC50 = 19 gm/m3; Oral, rat: LD50 = 500 mg/kg.
Carcinogenicity:
Methanol - Not listed by ACGIH, IARC, or NTP.
Trimethylamine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 65-55-0 unlisted.
CAS# 75-50-3: PA0350000 LD50/LC50:
Not available.
CAS# 75-50-3: Inhalation, mouse: LC50 = 19 gm/m3; Oral, rat: LD50 = 500 mg/kg.
Carcinogenicity:
Methanol - Not listed by ACGIH, IARC, or NTP.
Trimethylamine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: FLAMMABLE LIQUID, TOXIC NOS
Hazard Class: 3
UN Number: 1992
Packing Group: II
IMO
Shipping Name: FLAMMABLE LIQUID, TOXIC NOS
Hazard Class: 3
UN Number: 1992
Packing Group: II
RID/ADR
Shipping Name: FLAMMABLE LIQUID, TOXIC NOS
Hazard Class: 3
UN Number: 1992
Packing group: II
USA RQ: CAS# 75-50-3: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 23/25 Toxic by inhalation and if swallowed.
R 36/37 Irritating to eyes and respiratory system.
Safety Phrases:
S 7 Keep container tightly closed.
S 16 Keep away from sources of ignition - No
smoking.
S 24 Avoid contact with skin.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 65-55-0: No information available.
CAS# 75-50-3: 2
Canada
CAS# 75-50-3 is listed on Canadas DSL List.
CAS# 65-55-0 is not listed on Canadas Ingredient Disclosure List.
CAS# 75-50-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 65-55-0 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 75-50-3 is listed on the TSCA inventory.
