Name:
4-Methyl-2-Pentanone P.A.
Synonym:
Hexone, Isopropylacetone, 4-Methyl-2-Oxopentane, MIBK
CAS:
108-10-1
Section 1 - Chemical Product
MSDS Name:4-Methyl-2-Pentanone P.A.
Synonym:Hexone, Isopropylacetone, 4-Methyl-2-Oxopentane, MIBK
Synonym:Hexone, Isopropylacetone, 4-Methyl-2-Oxopentane, MIBK
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 108-10-1 | Methyl isobutyl ketone | >98.5 | 203-550-1 |
| Hazard Symbols: F Risk Phrases: 11 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable.
Potential Health Effects
Eye:
Vapors may cause eye irritation. May cause painful sensitization to light. Contact produces irritation, tearing, and burning pain.
Skin:
Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for inhalation exposure.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Exposure produces central nervous system depression. May cause liver abnormalities.
May cause visual abnormalities.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis.
Highly flammable.
Potential Health Effects
Eye:
Vapors may cause eye irritation. May cause painful sensitization to light. Contact produces irritation, tearing, and burning pain.
Skin:
Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for inhalation exposure.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Exposure produces central nervous system depression. May cause liver abnormalities.
May cause visual abnormalities.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
Skin:
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid if cough or other symptoms appear.
Notes to Physician:
Skin:
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid if cough or other symptoms appear.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section).
Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as saw dust.
Provide ventilation.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section).
Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as saw dust.
Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: clear, colorless
Odor: Sweet, camphor-like.
pH: Not available.
Vapor Pressure: 15.7 mm Hg @ 20
Viscosity: Not available.
Boiling Point: 117.4 deg C @ 760.00mm Hg
Freezing/Melting Point: -84 deg C
Autoignition Temperature: 460 deg C ( 860.00 deg F)
Flash Point: 14 deg C ( 57.20 deg F)
Explosion Limits, lower: 1.40 vol %
Explosion Limits, upper: 7.50 vol %
Decomposition Temperature:
Solubility in water: 17 g/l (20 c)
Specific Gravity/Density: .8010g/cm3
Molecular Formula: C6H12O
Molecular Weight: 100.16
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, potassium tert-butoxide, reducing agents, strong bases. Substance may form explosive peroxides with air.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, potassium tert-butoxide, reducing agents, strong bases. Substance may form explosive peroxides with air.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 108-10-1: SA9275000 LD50/LC50:
CAS# 108-10-1: Draize test, rabbit, eye: 40 mg Severe; Draize test, rabbit, eye: 100 uL/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 23300 mg/m3; Inhalation, rat: LC50 = 100 gm/m3; Oral, mouse: LD50 = 1900 mg/kg; Oral, rat: LD50 = 2080 mg/kg.
Carcinogenicity:
Methyl isobutyl ketone - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 108-10-1: SA9275000 LD50/LC50:
CAS# 108-10-1: Draize test, rabbit, eye: 40 mg Severe; Draize test, rabbit, eye: 100 uL/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 23300 mg/m3; Inhalation, rat: LC50 = 100 gm/m3; Oral, mouse: LD50 = 1900 mg/kg; Oral, rat: LD50 = 2080 mg/kg.
Carcinogenicity:
Methyl isobutyl ketone - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 505 mg/L; 96 Hr.; Flow through; 25 degrees C, pH 7.5Fish: Goldfish: LC50 = 460 mg/L; 24 Hr.; UnspecifiedWater flea Daphnia: EC50 = 4280.0 mg/L; 24 Hr.; UnspecifiedAlgae: EC50 = 400 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 79.6 mg/L; 5 minutes; Microtox testRedwinged blackbird, oral LD50=100mg/kg. Goldfish LC50=460mg/L/24H.
Fish: Fathead Minnow: LC50 = 505 mg/L; 96 Hr.; Flow through; 25 degrees C, pH 7.5Fish: Goldfish: LC50 = 460 mg/L; 24 Hr.; UnspecifiedWater flea Daphnia: EC50 = 4280.0 mg/L; 24 Hr.; UnspecifiedAlgae: EC50 = 400 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 79.6 mg/L; 5 minutes; Microtox testRedwinged blackbird, oral LD50=100mg/kg. Goldfish LC50=460mg/L/24H.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: METHYL ISOBUTYL KETONE
Hazard Class: 3
UN Number: 1245
Packing Group: II
IMO
Shipping Name: METHYL ISOBUTYL KETONE
Hazard Class: 3.2
UN Number: 1245
Packing Group: II
RID/ADR
Shipping Name: METHYL ISOBUTYL KETONE
Dangerous Goods Code: 3(3B)
UN Number: 1245
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F
Risk Phrases:
R 11 Highly flammable.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 23 Do not inhale gas/fumes/vapour/spray.
S 33 Take precautionary measures against static
discharges.
WGK (Water Danger/Protection)
CAS# 108-10-1: 1
United Kingdom Occupational Exposure Limits
CAS# 108-10-1: OES-United Kingdom, TWA 50 ppm TWA; 208 mg/m3 TWA
CAS# 108-10-1: OES-United Kingdom, STEL 100 ppm STEL; 416 mg/m3 STEL
Canada
CAS# 108-10-1 is listed on Canadas DSL List.
CAS# 108-10-1 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 108-10-1: Not available.
US FEDERAL
TSCA
CAS# 108-10-1 is listed on the TSCA inventory.
