Name:
Acetone cyanohydrin stabilized with
Synonym:
2-Hydroxyisobutyronitrile; 2-Methyllactonitrile
CAS:
75-86-5
Section 1 - Chemical Product
MSDS Name:Acetone cyanohydrin stabilized with
Synonym:2-Hydroxyisobutyronitrile; 2-Methyllactonitrile
Synonym:2-Hydroxyisobutyronitrile; 2-Methyllactonitrile
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 75-86-5 | Acetone cyanohydrin | >98 | 200-909-4 |
| Hazard Symbols: T+ N Risk Phrases: 26/27/28 50/53 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
May be fatal if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. May cause irritation and dermatitis. May cause cyanosis of the extremities.
Ingestion:
May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Human fatalities have been reported from acute poisoning. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by asphyxiation.
Inhalation:
May cause respiratory tract irritation. May cause liver and kidney damage. Aspiration may lead to pulmonary edema. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. Inhalation may result in symptoms similar to cyanide poisoning which include tachypnea, hyperpnea (abnormally rapid or deep breathing), and dyspnea (labored breathing) followed rapidly by respiratory depression. Pulmonary edema may occur.
Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
May cause liver and kidney damage. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
Very toxic by inhalation, in contact with skin and if swallowed.
Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
May be fatal if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. May cause irritation and dermatitis. May cause cyanosis of the extremities.
Ingestion:
May be fatal if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Human fatalities have been reported from acute poisoning. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by asphyxiation.
Inhalation:
May cause respiratory tract irritation. May cause liver and kidney damage. Aspiration may lead to pulmonary edema. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. Inhalation may result in symptoms similar to cyanide poisoning which include tachypnea, hyperpnea (abnormally rapid or deep breathing), and dyspnea (labored breathing) followed rapidly by respiratory depression. Pulmonary edema may occur.
Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
May cause liver and kidney damage. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. SPEEDY ACTION IS CRITICAL! Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. SPEEDY ACTION IS CRITICAL! Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 75-86-5: Belgium - STEL: 4.7 ppm VLE; 5.1 mg/m3 VLE Malaysia: 4.7 ppm Ceiling (as CN); 5 mg/m3 Ceiling (as CN) Netherlands: 10 ppm STEL; 35 mg/m3 STEL Netherlands: 1 ppm MAC; 3.5 mg/m3 MAC Russia: 0.9 mg/m3 TWA Spain: 5 mg/m3 VLA-EC (as CN) CAS# 7664-93-9: United States OSHA: 1 mg/m3 TWA Belgium - TWA: 1 mg/m3 VLE Belgium - STEL: 3 mg/m3 VLE France - VME: 1 mg/m3 VME France - VLE: 3 mg/m3 VLE Germany: 0.5 mg/m3 TWA (inhalable fraction, battery manufacture, metal working in a close Japan: 1 mg/m3 Ceiling Malaysia: 1 mg/m3 TWA Netherlands: 1 mg/m3 MAC Russia: 1 mg/m3 TWA Spain: 1 mg/m3 VLA-ED Spain: 3 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 75-86-5: Belgium - STEL: 4.7 ppm VLE; 5.1 mg/m3 VLE Malaysia: 4.7 ppm Ceiling (as CN); 5 mg/m3 Ceiling (as CN) Netherlands: 10 ppm STEL; 35 mg/m3 STEL Netherlands: 1 ppm MAC; 3.5 mg/m3 MAC Russia: 0.9 mg/m3 TWA Spain: 5 mg/m3 VLA-EC (as CN) CAS# 7664-93-9: United States OSHA: 1 mg/m3 TWA Belgium - TWA: 1 mg/m3 VLE Belgium - STEL: 3 mg/m3 VLE France - VME: 1 mg/m3 VME France - VLE: 3 mg/m3 VLE Germany: 0.5 mg/m3 TWA (inhalable fraction, battery manufacture, metal working in a close Japan: 1 mg/m3 Ceiling Malaysia: 1 mg/m3 TWA Netherlands: 1 mg/m3 MAC Russia: 1 mg/m3 TWA Spain: 1 mg/m3 VLA-ED Spain: 3 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: bitter-almond
pH: Not available.
Vapor Pressure: 1 mbar @ 20 C
Viscosity: Not available.
Boiling Point: 69 deg C
Freezing/Melting Point: -19 deg C
Autoignition Temperature: 688 deg C ( 1,270.40 deg F)
Flash Point: 73.8 deg C ( 164.84 deg F)
Explosion Limits, lower: 2.2
Explosion Limits, upper: 12.0
Decomposition Temperature:
Solubility in water: Freely Soluble.
Specific Gravity/Density: .9320g/cm3
Molecular Formula: C4H7NO
Molecular Weight: 85.11
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents Hazardous Decomposition Products:
Hydrogen cyanide, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents Hazardous Decomposition Products:
Hydrogen cyanide, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 75-86-5: OD9275000 CAS# 7664-93-9: WS5600000 LD50/LC50:
CAS# 75-86-5: Dermal, guinea pig: LD50 = 150 mg/kg; Oral, mouse: LD50 = 1898 ug/kg; Oral, rabbit: LD50 = 13500 ug/kg; Oral, rat: LD50 = 18650 ug/kg; Skin, rabbit: LD50 = 17 uL/kg.
CAS# 7664-93-9: Draize test, rabbit, eye: 250 ug Severe; Inhalation, mouse: LC50 = 320 mg/m3/2H; Inhalation, mouse: LC50 = 320 mg/m3; Inhalation, rat: LC50 = 510 mg/m3/2H; Inhalation, rat: LC50 = 510 mg/m3; Oral, rat: LD50 = 2140 mg/kg.
Carcinogenicity:
Acetone cyanohydrin - Not listed by ACGIH, IARC, or NTP.
Sulfuric acid - ACGIH: A2 - Suspected Human Carcinogen (contained in strong inorg California: carcinogen, initial date 3/14/03 (listed as Strong inorgan NTP: Known carcinogen (listed as Strong inorganic acid mists co IARC: Group 1 carcinogen Other:
See actual entry in RTECS for complete information.
CAS# 75-86-5: OD9275000 CAS# 7664-93-9: WS5600000 LD50/LC50:
CAS# 75-86-5: Dermal, guinea pig: LD50 = 150 mg/kg; Oral, mouse: LD50 = 1898 ug/kg; Oral, rabbit: LD50 = 13500 ug/kg; Oral, rat: LD50 = 18650 ug/kg; Skin, rabbit: LD50 = 17 uL/kg.
CAS# 7664-93-9: Draize test, rabbit, eye: 250 ug Severe; Inhalation, mouse: LC50 = 320 mg/m3/2H; Inhalation, mouse: LC50 = 320 mg/m3; Inhalation, rat: LC50 = 510 mg/m3/2H; Inhalation, rat: LC50 = 510 mg/m3; Oral, rat: LD50 = 2140 mg/kg.
Carcinogenicity:
Acetone cyanohydrin - Not listed by ACGIH, IARC, or NTP.
Sulfuric acid - ACGIH: A2 - Suspected Human Carcinogen (contained in strong inorg California: carcinogen, initial date 3/14/03 (listed as Strong inorgan NTP: Known carcinogen (listed as Strong inorganic acid mists co IARC: Group 1 carcinogen Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ACETONE CYANOHYDRIN, STABILIZED
Hazard Class: 6.1
UN Number: 1541
Packing Group: I
IMO
Shipping Name: ACETONE CYANOHYDRIN, STABILIZED
Hazard Class: 6.1
UN Number: 1541
Packing Group: I
RID/ADR
Shipping Name: ACETONE CYANOHYDRIN, STABILIZED
Hazard Class: 6.1
UN Number: 1541
Packing group: I
USA RQ: CAS# 75-86-5: 10 lb final RQ; 4.54 kg final RQ
USA RQ: CAS# 7664-93-9: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 7/9 Keep container tightly closed and in a
well-ventilated place.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 75-86-5: 3
CAS# 7664-93-9: 2
Canada
CAS# 75-86-5 is listed on Canadas DSL List.
CAS# 7664-93-9 is listed on Canadas DSL List.
CAS# 75-86-5 is listed on Canadas Ingredient Disclosure List.
CAS# 7664-93-9 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-86-5 is listed on the TSCA inventory.
CAS# 7664-93-9 is listed on the TSCA inventory.
