Name:
Acetonitrile-d3 99.9 Atom% D
Synonym:
Cyanomethane; Ethanenitrile; Ethyl Nitrile; Methanecarbonitrile; Methyl Cyanide; Methane, Cyano-; ACE
CAS:
2206-26-0
Section 1 - Chemical Product
MSDS Name:Acetonitrile-d3 99.9 Atom% D
Synonym:Cyanomethane; Ethanenitrile; Ethyl Nitrile; Methanecarbonitrile; Methyl Cyanide; Methane, Cyano-; ACE
Synonym:Cyanomethane; Ethanenitrile; Ethyl Nitrile; Methanecarbonitrile; Methyl Cyanide; Methane, Cyano-; ACE
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 2206-26-0 |
| Hazard Symbols: T F Risk Phrases: |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Toxic by inhalation, in contact with skin and if swallowed.Flammable liquid.Hygroscopic.Lachrymator (substance which increases the flow of tears).
Potential Health Effects
Eye:
Causes severe eye irritation. Lachrymator (substance which increases the flow of tears). May produce superficial reversible injury.
Skin:
Causes mild skin irritation. May be harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause muscle tremor and impaired motor function. May cause liver and kidney damage. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause effects similar to those for inhalation exposure. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea.
Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause central nervous system effects. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by asphyxiation.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea (labored breathing), and death. Aspiration may lead to pulmonary edema. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Vapors may cause dizziness or suffocation. Causes upper respiratory tract irritation. Inhalation may lead to dizziness, weakness, and drowsiness, leading to stupor, unconsciousness, and even death.
Inhalation may lead to hematemesis, convulsions, shock, coma, and possible death. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death. May cause reproductive and fetal effects. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen.
Laboratory experiments have resulted in mutagenic effects.
Highly flammable. Toxic by inhalation, in contact with skin and if swallowed.Flammable liquid.Hygroscopic.Lachrymator (substance which increases the flow of tears).
Potential Health Effects
Eye:
Causes severe eye irritation. Lachrymator (substance which increases the flow of tears). May produce superficial reversible injury.
Skin:
Causes mild skin irritation. May be harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause muscle tremor and impaired motor function. May cause liver and kidney damage. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause effects similar to those for inhalation exposure. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea.
Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause central nervous system effects. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by asphyxiation.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea (labored breathing), and death. Aspiration may lead to pulmonary edema. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Vapors may cause dizziness or suffocation. Causes upper respiratory tract irritation. Inhalation may lead to dizziness, weakness, and drowsiness, leading to stupor, unconsciousness, and even death.
Inhalation may lead to hematemesis, convulsions, shock, coma, and possible death. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death. May cause reproductive and fetal effects. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen.
Laboratory experiments have resulted in mutagenic effects.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Treat patient as for inhalation.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. Keep warm and at rest. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be delayed. May be partially metabolized to cyanide in the body. For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Antidote: Always have a cyanide antidote kit on hand when working with cyanide compounds. Get medical advice to use. Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Treat patient as for inhalation.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. Keep warm and at rest. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Exposure should be treated as a cyanide poisoning. Effects may be delayed. May be partially metabolized to cyanide in the body. For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Antidote: Always have a cyanide antidote kit on hand when working with cyanide compounds. Get medical advice to use. Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective.
Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective.
Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water may be ineffective. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture. Substance is packaged under argon in 100 ml. acroseal containers.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture. Substance is packaged under argon in 100 ml. acroseal containers.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Clear liquid
Color: colorless
Odor: aromatic odor - sweetish odor
pH: Not available.
Vapor Pressure: 97 mbar @ 20 deg C
Viscosity: 0.39 cP 20 deg C
Boiling Point: 79-81 deg C @ 760 mmHg
Freezing/Melting Point: -46 deg C
Autoignition Temperature: 525 deg C ( 977.00 deg F)
Flash Point: 2 deg C ( 35.60 deg F)
Explosion Limits, lower: 3.00 vol %
Explosion Limits, upper: 16.00 vol %
Decomposition Temperature:
Solubility in water: Miscible.
Specific Gravity/Density: .8440
Molecular Formula: CD3CN
Molecular Weight: 44.0487
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, exposure to moist air or water, oxidizers, temperatures above 40C.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, bases, alkali metals, fluorine, nitric acid, perchlorates, sulfuric acid, chlorosulfonic acid, oleum, dinitrogen tetraoxide, sulfites, indium, moisture, Attacks some forms of plastics, rubbers, and coatings., nitrating agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile), lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl nitrate, trichlorosilane, diphenyl sulfoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, exposure to moist air or water, oxidizers, temperatures above 40C.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, bases, alkali metals, fluorine, nitric acid, perchlorates, sulfuric acid, chlorosulfonic acid, oleum, dinitrogen tetraoxide, sulfites, indium, moisture, Attacks some forms of plastics, rubbers, and coatings., nitrating agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile), lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl nitrate, trichlorosilane, diphenyl sulfoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 2206-26-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Acetonitrile-d3 - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 2206-26-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Acetonitrile-d3 - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 1020mg/L; 96hr; hard waterFish: Bluegill/Sunfish: 1850 mg/L; 96hr; soft waterAlgae: 7300 mg/L; ;Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish: 1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; EC50 (flow-bioassay) Other Biodegradable.
Fish: Fathead Minnow: 1020mg/L; 96hr; hard waterFish: Bluegill/Sunfish: 1850 mg/L; 96hr; soft waterAlgae: 7300 mg/L; ;Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish: 1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; EC50 (flow-bioassay) Other Biodegradable.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
IMO
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing Group: II
RID/ADR
Shipping Name: ACETONITRILE
Hazard Class: 3
UN Number: 1648
Packing group:
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 27 Take off immediately all contaminated clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 2206-26-0: No information available.
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 2206-26-0 is not listed on Canadas Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 2206-26-0 is not listed on the TSCA inventory.
It is for research and development use only.
