Name:
Acetophenone 99%
Synonym:
Methyl phenyl ketone; Phenyl methyl ketone
CAS:
98-86-2
Section 1 - Chemical Product
MSDS Name:Acetophenone 99%
Synonym:Methyl phenyl ketone; Phenyl methyl ketone
Synonym:Methyl phenyl ketone; Phenyl methyl ketone
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 98-86-2 | Acetophenone | 99 | 202-708-7 |
| Hazard Symbols: XN Risk Phrases: 22 36 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes.
Potential Health Effects
Eye:
May cause transient corneal injury. Causes severe eye irritation and possible injury.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and dermatitis. Narcotic in high concentrations.
Harmful if swallowed. Irritating to eyes.
Potential Health Effects
Eye:
May cause transient corneal injury. Causes severe eye irritation and possible injury.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and dermatitis. Narcotic in high concentrations.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Exposure indicators: Acetophenone in expired air and hippuric acid in urine. Treat symptomatically and supportively.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Exposure indicators: Acetophenone in expired air and hippuric acid in urine. Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid and vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid and vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat and flame. Avoid breathing spray or mist.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat and flame. Avoid breathing spray or mist.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 98-86-2:
Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE Malaysia: 10 ppm TWA; 49 mg/m3 TWA Netherlands: 10 ppm MAC; 49 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 10 ppm VLA-ED; 50 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 98-86-2:
Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE Malaysia: 10 ppm TWA; 49 mg/m3 TWA Netherlands: 10 ppm MAC; 49 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 10 ppm VLA-ED; 50 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless - slightly oily
Odor: orange blossom
pH: Not available.
Vapor Pressure: 0.33 mm Hg @ 20 deg C
Viscosity: 1.62 cP @ 25 deg C
Boiling Point: 202 deg C @ 760 mm Hg
Freezing/Melting Point: 19.6 deg C
Autoignition Temperature: 570 deg C ( 1,058.00 deg F)
Flash Point: 77 deg C ( 170.60 deg F)
Explosion Limits, lower: 1.1%
Explosion Limits, upper: 6.7%
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 1.0296 @ 20C
Molecular Formula: C8H8O
Molecular Weight: 120.15
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong bases, perchloric acid, aldehydes, nitric acid + hydrogen peroxide.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong bases, perchloric acid, aldehydes, nitric acid + hydrogen peroxide.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 98-86-2: AM5250000 LD50/LC50:
CAS# 98-86-2: Dermal, guinea pig: LD50 = >20 mL/kg; Draize test, rabbit, eye: 750 ug Severe; Inhalation, mouse: LC50 = 1200 mg/m3/4H; Oral, mouse: LD50 = 740 mg/kg; Oral, mouse: LD50 = 1250 mg/kg; Oral, rat: LD50 = 815 mg/kg; Oral, rat: LD50 = 2650 mg/kg; Skin, rabbit: LD50 = 15900 uL/kg.
Carcinogenicity:
Acetophenone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 98-86-2: AM5250000 LD50/LC50:
CAS# 98-86-2: Dermal, guinea pig: LD50 = >20 mL/kg; Draize test, rabbit, eye: 750 ug Severe; Inhalation, mouse: LC50 = 1200 mg/m3/4H; Oral, mouse: LD50 = 740 mg/kg; Oral, mouse: LD50 = 1250 mg/kg; Oral, rat: LD50 = 815 mg/kg; Oral, rat: LD50 = 2650 mg/kg; Skin, rabbit: LD50 = 15900 uL/kg.
Carcinogenicity:
Acetophenone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 196 mg/L; 96 Hr; Flow-through at 24.6 C (pH 7.83)Bacteria: Phytobacterium phosphoreum: EC50 = 15.5 mg/L; 5,15,30 min; Microtox test at 15 CIf released to soil, microbial degradation is likely to be the major degradation pathway. It is expected to be moderately to highly mobile in soil and may evaporate from dry soil surfaces. Biodegradation and volatilization are expected to be the major loss processes in water. The estimated biodegradation half-lives in groundwater, river water and lake water samples were 32 days, 8 days and 4.5 days, respectively.
Fish: Fathead Minnow: LC50 = 196 mg/L; 96 Hr; Flow-through at 24.6 C (pH 7.83)Bacteria: Phytobacterium phosphoreum: EC50 = 15.5 mg/L; 5,15,30 min; Microtox test at 15 CIf released to soil, microbial degradation is likely to be the major degradation pathway. It is expected to be moderately to highly mobile in soil and may evaporate from dry soil surfaces. Biodegradation and volatilization are expected to be the major loss processes in water. The estimated biodegradation half-lives in groundwater, river water and lake water samples were 32 days, 8 days and 4.5 days, respectively.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
USA RQ: CAS# 98-86-2: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 98-86-2: 1
Canada
CAS# 98-86-2 is listed on Canadas DSL List.
CAS# 98-86-2 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 98-86-2 is listed on the TSCA inventory.
