Name:
Ammonium-d4 deuteroxide 26 wt % solution in D2O 99+ atom % D
Synonym:
None
CAS:
1336-21-6
Section 1 - Chemical Product
MSDS Name:Ammonium-d4 deuteroxide 26 wt % solution in D2O 99+ atom % D
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 1336-21-6 | Water-d2 | 74 | 232-148-9 |
| Hazard Symbols: C Risk Phrases: 34 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Contact with liquid or vapor causes severe burns and possible irreversible eye damage. Lachrymator (substance which increases the flow of tears).
Skin:
Causes severe skin irritation. Causes skin burns. May cause deep, penetrating ulcers of the skin. Contact with the skin may cause staining, inflammation, and thickening of the skin.
Ingestion:
Harmful if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. Causes throat constriction, vomiting, convulsions, and shock.
Inhalation:
Effects may be delayed. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma.
Chronic:
Prolonged inhalation may cause respiratory tract inflammation and lung damage. Prolonged or repeated exposure may cause corneal damage and the development of cataracts and glaucoma.
Causes burns.
Potential Health Effects
Eye:
Contact with liquid or vapor causes severe burns and possible irreversible eye damage. Lachrymator (substance which increases the flow of tears).
Skin:
Causes severe skin irritation. Causes skin burns. May cause deep, penetrating ulcers of the skin. Contact with the skin may cause staining, inflammation, and thickening of the skin.
Ingestion:
Harmful if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. Causes throat constriction, vomiting, convulsions, and shock.
Inhalation:
Effects may be delayed. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma.
Chronic:
Prolonged inhalation may cause respiratory tract inflammation and lung damage. Prolonged or repeated exposure may cause corneal damage and the development of cataracts and glaucoma.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
After inhalation exposure, observe for 24 to 72 hours as pulmonary edema may be delayed.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
After inhalation exposure, observe for 24 to 72 hours as pulmonary edema may be delayed.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Ammonium hydroxide itself is non-combustible. However concentrated ammonia solutions may give off ammonia vapours. Ammonia gas is generally not considered a serious fire or explosion hazard because ammonia/air mixtures are difficult to ignite. A relatively high concentration of ammonia gas must be present in order for ignition to occur. However, a large and intense energy source may cause ignition and/or explosion in a confined space.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Ammonium hydroxide itself is non-combustible. However concentrated ammonia solutions may give off ammonia vapours. Ammonia gas is generally not considered a serious fire or explosion hazard because ammonia/air mixtures are difficult to ignite. A relatively high concentration of ammonia gas must be present in order for ignition to occur. However, a large and intense energy source may cause ignition and/or explosion in a confined space.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Neutralize spill with a weak acid such as vinegar or acetic acid. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Approach spill from upwind.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Neutralize spill with a weak acid such as vinegar or acetic acid. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Approach spill from upwind.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Discard contaminated shoes. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Isolate from oxidizing materials and acids. Walls, floors, shelving, fittings, lighting and ventilation systems in storage area should be made from carbon steel or stainless steel which do not react with ammonium hydroxide.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Discard contaminated shoes. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Isolate from oxidizing materials and acids. Walls, floors, shelving, fittings, lighting and ventilation systems in storage area should be made from carbon steel or stainless steel which do not react with ammonium hydroxide.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 1336-21-6: CAS# 7664-41-7: United Kingdom, WEL - TWA: 25 ppm TWA (anhydrous); 18 mg/m3 TWA (anhydrous) United Kingdom, WEL - STEL: 35 ppm STEL (anhydrous); 25 mg/m3 STE (anhydrous) United States OSHA: 50 ppm TWA; 35 mg/m3 TWA Belgium - TWA: 20 ppm VLE; 14 mg/m3 VLE Belgium - STEL: 50 ppm VLE; 36 mg/m3 VLE France - VME: 25 ppm VME; 18 mg/m3 VME France - VLE: 50 ppm VLE; 36 mg/m3 VLE Germany: 50 ppm TWA; 35 mg/m3 TWA Japan: 25 ppm OEL; 17 mg/m3 OEL Malaysia: 25 ppm TWA; 17 mg/m3 TWA Netherlands: 50 ppm STEL; 36 mg/m3 STEL Netherlands: 20 ppm MAC; 14 mg/m3 MAC Russia: 20 mg/m3 TWA Spain: 20 ppm VLA-ED; 14 mg/m3 VLA-ED Spain: 50 ppm VLA-EC; 36 mg/m3 VLA-EC CAS# 7789-20-0: CAS# 12168-30-8: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 1336-21-6: CAS# 7664-41-7: United Kingdom, WEL - TWA: 25 ppm TWA (anhydrous); 18 mg/m3 TWA (anhydrous) United Kingdom, WEL - STEL: 35 ppm STEL (anhydrous); 25 mg/m3 STE (anhydrous) United States OSHA: 50 ppm TWA; 35 mg/m3 TWA Belgium - TWA: 20 ppm VLE; 14 mg/m3 VLE Belgium - STEL: 50 ppm VLE; 36 mg/m3 VLE France - VME: 25 ppm VME; 18 mg/m3 VME France - VLE: 50 ppm VLE; 36 mg/m3 VLE Germany: 50 ppm TWA; 35 mg/m3 TWA Japan: 25 ppm OEL; 17 mg/m3 OEL Malaysia: 25 ppm TWA; 17 mg/m3 TWA Netherlands: 50 ppm STEL; 36 mg/m3 STEL Netherlands: 20 ppm MAC; 14 mg/m3 MAC Russia: 20 mg/m3 TWA Spain: 20 ppm VLA-ED; 14 mg/m3 VLA-ED Spain: 50 ppm VLA-EC; 36 mg/m3 VLA-EC CAS# 7789-20-0: CAS# 12168-30-8: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless liquid
Odor: ammonia-like
pH: Not available.
Vapor Pressure: > 112.5 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: 651 deg C ( 1,203.80 deg F)
Flash Point: Not applicable.
Explosion Limits, lower: 15%
Explosion Limits, upper: 28%
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: D5NO
Molecular Weight: 40.09
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Ammonium hydroxide is actually a solution of ammonia in water. Therefore the flammable properties of ammonia apply.
Conditions to Avoid:
High temperatures, confined spaces, Ammonia solutions are corrosive to copper, zinc, aluminum and their alloys..
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acrolein, halogens, mercury, hypochlorite, silver nitrate, acrylic acid, dimethyl sulfate, silver oxide.
Hazardous Decomposition Products:
Nitrogen oxides (NOx) and ammonia (NH3).
Hazardous Polymerization: Has not been reported
Stable under normal temperatures and pressures. Ammonium hydroxide is actually a solution of ammonia in water. Therefore the flammable properties of ammonia apply.
Conditions to Avoid:
High temperatures, confined spaces, Ammonia solutions are corrosive to copper, zinc, aluminum and their alloys..
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acrolein, halogens, mercury, hypochlorite, silver nitrate, acrylic acid, dimethyl sulfate, silver oxide.
Hazardous Decomposition Products:
Nitrogen oxides (NOx) and ammonia (NH3).
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1336-21-6: BQ9625000 CAS# 7664-41-7: BO0875000 CAS# 7789-20-0: ZC0230000 CAS# 12168-30-8 unlisted.
LD50/LC50:
CAS# 1336-21-6: Draize test, rabbit, eye: 250 ug Severe; Draize test, rabbit, eye: 44 ug Severe; Oral, rat: LD50 = 350 mg/kg.
CAS# 7664-41-7: Inhalation, mouse: LC50 = 4230 ppm/1H; Inhalation, mouse: LC50 = 4600 mg/m3/2H; Inhalation, rabbit: LC50 = 7 gm/m3/1H; Inhalation, rat: LC50 = 2000 ppm/4H; Inhalation, rat: LC50 = 18600 mg/m3/5M; Inhalation, rat: LC50 = 7040 mg/m3/30M; Skin, rat: LD50 = 112000 mg/m3/15M; Skin, rat: LD50 = 71900 mg/m3/30M; Skin, rat: LD50 = 4840 mg/m3/60M.
CAS# 7789-20-0.
CAS# 12168-30-8.
Carcinogenicity:
Ammonium hydroxide - Not listed by ACGIH, IARC, or NTP.
Ammonia - Not listed by ACGIH, IARC, or NTP.
Water-d2 - Not listed by ACGIH, IARC, or NTP.
Ammonium-d4 deuteroxide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 1336-21-6: BQ9625000 CAS# 7664-41-7: BO0875000 CAS# 7789-20-0: ZC0230000 CAS# 12168-30-8 unlisted.
LD50/LC50:
CAS# 1336-21-6: Draize test, rabbit, eye: 250 ug Severe; Draize test, rabbit, eye: 44 ug Severe; Oral, rat: LD50 = 350 mg/kg.
CAS# 7664-41-7: Inhalation, mouse: LC50 = 4230 ppm/1H; Inhalation, mouse: LC50 = 4600 mg/m3/2H; Inhalation, rabbit: LC50 = 7 gm/m3/1H; Inhalation, rat: LC50 = 2000 ppm/4H; Inhalation, rat: LC50 = 18600 mg/m3/5M; Inhalation, rat: LC50 = 7040 mg/m3/30M; Skin, rat: LD50 = 112000 mg/m3/15M; Skin, rat: LD50 = 71900 mg/m3/30M; Skin, rat: LD50 = 4840 mg/m3/60M.
CAS# 7789-20-0.
CAS# 12168-30-8.
Carcinogenicity:
Ammonium hydroxide - Not listed by ACGIH, IARC, or NTP.
Ammonia - Not listed by ACGIH, IARC, or NTP.
Water-d2 - Not listed by ACGIH, IARC, or NTP.
Ammonium-d4 deuteroxide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Rainbow trout: LC50 = 0.008 mg/L; 24 Hr.; UnspecifiedFish: Fathead Minnow: LC50 = 8.2 mg/L; 96 Hr.; UnspecifiedFish: Bluegill/Sunfish: LC50 = 0.024-0.093 mg/L; 48 Hr.; UnspecifiedWater flea Daphnia: EC50 =0.66 mg/L; 48 Hr.; 22 degrees C
Fish: Rainbow trout: LC50 = 0.008 mg/L; 24 Hr.; UnspecifiedFish: Fathead Minnow: LC50 = 8.2 mg/L; 96 Hr.; UnspecifiedFish: Bluegill/Sunfish: LC50 = 0.024-0.093 mg/L; 48 Hr.; UnspecifiedWater flea Daphnia: EC50 =0.66 mg/L; 48 Hr.; 22 degrees C
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: AMMONIA SOLUTION
Hazard Class: 8
UN Number: 2672
Packing Group: III
IMO
Shipping Name: AMMONIA SOLUTION
Hazard Class: 8
UN Number: 2672
Packing Group: III
RID/ADR
Shipping Name: AMMONIA SOLUTION
Hazard Class: 8
UN Number: 2672
Packing group: III
USA RQ: CAS# 1336-21-6: 1000 lb final RQ; 454 kg final RQ
USA RQ: CAS# 7664-41-7: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1336-21-6: 2
CAS# 7664-41-7: 2
CAS# 7789-20-0: No information available.
CAS# 12168-30-8: No information available.
Canada
CAS# 1336-21-6 is listed on Canadas DSL List.
CAS# 7664-41-7 is listed on Canadas DSL List.
CAS# 7789-20-0 is listed on Canadas DSL List.
CAS# 1336-21-6 is listed on Canadas Ingredient Disclosure List.
CAS# 7664-41-7 is listed on Canadas Ingredient Disclosure List.
CAS# 7789-20-0 is not listed on Canadas Ingredient Disclosure List.
CAS# 12168-30-8 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1336-21-6 is listed on the TSCA inventory.
CAS# 7664-41-7 is listed on the TSCA inventory.
CAS# 7789-20-0 is listed on the TSCA inventory.
CAS# 12168-30-8 is not listed on the TSCA inventory.
It is for research and development use only.
