Name:
AQUALINE Buffer
Synonym:
None Known
CAS:
67-56-1
Section 1 - Chemical Product
MSDS Name:AQUALINE Buffer
Synonym:None Known
Synonym:None Known
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-56-1 | Methyl alcohol | 65.0 | 200-659-6 |
| Hazard Symbols: T F Risk Phrases: 11 23/24/25 34 39/23/24/25 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Toxic by inhalation, in contact with skin and if swallowed. Causes burns. Toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause painful sensitization to light. May cause blindness.
Skin:
Causes skin burns. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May be fatal or cause blindness if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause perforation of the digestive tract. May cause cardiopulmonary system effects.
Inhalation:
Harmful if inhaled. Causes chemical burns to the respiratory tract.
May cause adverse central nervous system effects including headache, convulsions, and possible death. May cause visual impairment and possible permanent blindness. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Effects may be delayed. Chronic exposure may cause reproductive disorders and teratogenic effects. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause liver, kidney, and heart damage.
Highly flammable. Toxic by inhalation, in contact with skin and if swallowed. Causes burns. Toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause painful sensitization to light. May cause blindness.
Skin:
Causes skin burns. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May be fatal or cause blindness if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause perforation of the digestive tract. May cause cardiopulmonary system effects.
Inhalation:
Harmful if inhaled. Causes chemical burns to the respiratory tract.
May cause adverse central nervous system effects including headache, convulsions, and possible death. May cause visual impairment and possible permanent blindness. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Effects may be delayed. Chronic exposure may cause reproductive disorders and teratogenic effects. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause liver, kidney, and heart damage.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Ethanol may inhibit methanol metabolism. Effects may be delayed.
Antidote: Ethanol may inhibit methanol metabolism.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Ethanol may inhibit methanol metabolism. Effects may be delayed.
Antidote: Ethanol may inhibit methanol metabolism.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust.
Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust.
Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Do not store in aluminum or lead containers.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Do not store in aluminum or lead containers.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits CAS# 67-56-1: United Kingdom, WEL - TWA: 200 ppm TWA; 266 mg/m3 TWA United Kingdom, WEL - STEL: 250 ppm STEL; 333 mg/m3 STEL United States OSHA: 200 ppm TWA; 260 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 266 mg/m3 VLE Belgium - STEL: 250 ppm VLE; 333 mg/m3 VLE France - VME: 200 ppm VME; 260 mg/m3 VME France - VLE: 1000 ppm VLE; 1300 mg/m3 VLE Germany: 200 ppm TWA; 270 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 260 mg/m3 OEL Malaysia: 200 ppm TWA; 262 mg/m3 TWA Netherlands: 200 ppm MAC; 260 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 200 ppm VLA-ED; 266 mg/m3 VLA-ED Spain: 250 ppm VLA-EC; 333 mg/m3 VLA-EC CAS# 288-32-4: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits CAS# 67-56-1: United Kingdom, WEL - TWA: 200 ppm TWA; 266 mg/m3 TWA United Kingdom, WEL - STEL: 250 ppm STEL; 333 mg/m3 STEL United States OSHA: 200 ppm TWA; 260 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 266 mg/m3 VLE Belgium - STEL: 250 ppm VLE; 333 mg/m3 VLE France - VME: 200 ppm VME; 260 mg/m3 VME France - VLE: 1000 ppm VLE; 1300 mg/m3 VLE Germany: 200 ppm TWA; 270 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 260 mg/m3 OEL Malaysia: 200 ppm TWA; 262 mg/m3 TWA Netherlands: 200 ppm MAC; 260 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 200 ppm VLA-ED; 266 mg/m3 VLA-ED Spain: 250 ppm VLA-EC; 333 mg/m3 VLA-EC CAS# 288-32-4: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Not available.
Odor: alcohol-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 10 deg C ( 50.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: Solution
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, oxidizers.
Incompatibilities with Other Materials:
Strong acids, active metals, nitric acid, isocyanates, aliphatic amines, acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), acids (organic, e.g. acetic acid, benzoic acid, formic acid, methanoic acid, oxalic acid), azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), isocyanates (e.g. methyl isocyanate), nitrides (e.g. potassium nitride, sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone peroxide), epoxides (e.g. butyl glycidyl ether), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane), carbontetrachloride, cyanuric chloride, diethyl zinc, perchloric acid, chromic anh.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, formaldehyde.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, oxidizers.
Incompatibilities with Other Materials:
Strong acids, active metals, nitric acid, isocyanates, aliphatic amines, acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), acids (organic, e.g. acetic acid, benzoic acid, formic acid, methanoic acid, oxalic acid), azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), isocyanates (e.g. methyl isocyanate), nitrides (e.g. potassium nitride, sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone peroxide), epoxides (e.g. butyl glycidyl ether), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane), carbontetrachloride, cyanuric chloride, diethyl zinc, perchloric acid, chromic anh.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, formaldehyde.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-56-1: PC1400000 CAS# 288-32-4: NI3325000 LD50/LC50:
CAS# 67-56-1: Draize test, rabbit, eye: 40 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rabbit: LC50 = 81000 mg/m3/14H; Inhalation, rat: LC50 = 64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5600 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg.
CAS# 288-32-4: Oral, mouse: LD50 = 880 mg/kg; Oral, rat: LD50 = 220 mg/kg.
Carcinogenicity:
Methyl alcohol - Not listed by ACGIH, IARC, or NTP.
Imidazole - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 67-56-1: PC1400000 CAS# 288-32-4: NI3325000 LD50/LC50:
CAS# 67-56-1: Draize test, rabbit, eye: 40 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rabbit: LC50 = 81000 mg/m3/14H; Inhalation, rat: LC50 = 64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5600 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg.
CAS# 288-32-4: Oral, mouse: LD50 = 880 mg/kg; Oral, rat: LD50 = 220 mg/kg.
Carcinogenicity:
Methyl alcohol - Not listed by ACGIH, IARC, or NTP.
Imidazole - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 29.4 g/L; 96 Hr; LC50 (unspecified)Fish: Goldfish: 250 ppm; 11 Hr; resulted in deathFish: Rainbow trout: 8000 mg/L; 48 Hr; LC50 (unspecified)Fish: Rainbow trout: LC50 = 13-68 mg/L; 96 Hr.; 12 degrees CFish: Fathead Minnow: LC50 = 29400 mg/L; 96 Hr.; 25 degrees C, pH 7.63Fish: Rainbow trout: LC50 = 8000 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51,000-320,000 mg/L; 30 minutes; Microtox testFish: Pseudomonas putida:
Fish: Fathead Minnow: 29.4 g/L; 96 Hr; LC50 (unspecified)Fish: Goldfish: 250 ppm; 11 Hr; resulted in deathFish: Rainbow trout: 8000 mg/L; 48 Hr; LC50 (unspecified)Fish: Rainbow trout: LC50 = 13-68 mg/L; 96 Hr.; 12 degrees CFish: Fathead Minnow: LC50 = 29400 mg/L; 96 Hr.; 25 degrees C, pH 7.63Fish: Rainbow trout: LC50 = 8000 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51,000-320,000 mg/L; 30 minutes; Microtox testFish: Pseudomonas putida:
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
Hazard Class: 3
UN Number: 2924
Packing Group: II
IMO
Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
Hazard Class: 3
UN Number: 2924
Packing Group: II
RID/ADR
Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
Hazard Class: 3
UN Number: 2924
Packing group: II
USA RQ: CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 34 Causes burns.
R 39/23/24/25 Toxic : danger of very serious
irreversible effects through inhalation, in contact
with skin and if swallowed.
Safety Phrases:
S 7 Keep container tightly closed.
S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 67-56-1: 1
CAS# 288-32-4: 1
Canada
CAS# 67-56-1 is listed on Canadas DSL List.
CAS# 288-32-4 is listed on Canadas DSL List.
CAS# 67-56-1 is listed on Canadas Ingredient Disclosure List.
CAS# 288-32-4 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# 288-32-4 is listed on the TSCA inventory.
