Name:
Arsenic standard metal solution 1000 ppm in 2% HNO3
Synonym:
None
CAS:
1327-53-3
Section 1 - Chemical Product
MSDS Name:Arsenic standard metal solution 1000 ppm in 2% HNO3
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 1327-53-3 | Arsenic trioxide | 0.1 | 215-481-4 |
| Hazard Symbols: XN N Risk Phrases: 20/22 37/38 41 50/53 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed. Irritating to respiratory system and skin. Risk of serious damage to eyes. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes severe eye irritation and possible burns.
Skin:
Causes skin irritation. Concentrated nitric acid dyes human skin yellow on contact.
Ingestion:
May cause irritation of the digestive tract and possible burns.
Inhalation:
Causes respiratory tract irritation. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation.
Chronic:
Repeated inhalation may cause chronic bronchitis. Repeated exposure may cause erosion of teeth. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor. Inorganic arsenic compounds may cause skin and lung cancers in humans.
Harmful by inhalation and if swallowed. Irritating to respiratory system and skin. Risk of serious damage to eyes. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes severe eye irritation and possible burns.
Skin:
Causes skin irritation. Concentrated nitric acid dyes human skin yellow on contact.
Ingestion:
May cause irritation of the digestive tract and possible burns.
Inhalation:
Causes respiratory tract irritation. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation.
Chronic:
Repeated inhalation may cause chronic bronchitis. Repeated exposure may cause erosion of teeth. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor. Inorganic arsenic compounds may cause skin and lung cancers in humans.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. May react with metal surfaces to form flammable and explosive hydrogen gas. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Concentrated nitric acid is a strong oxidizer and contact with other material may cause fire.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. May react with metal surfaces to form flammable and explosive hydrogen gas. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Concentrated nitric acid is a strong oxidizer and contact with other material may cause fire.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation. Approach spill from upwind.
Spills/Leaks:
Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation. Approach spill from upwind.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid breathing vapor or mist. Do not use with metal spatula or other metal items. Do not get in eyes. Avoid contact with skin and clothing.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Store away from alkalies.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid breathing vapor or mist. Do not use with metal spatula or other metal items. Do not get in eyes. Avoid contact with skin and clothing.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Store away from alkalies.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits CAS# 1327-53-3: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As) United States OSHA: 0.5 mg/m3 TWA (listed under Arsenic).5 ??g/m3 Action Level (as As); 10 ??g/m3 PEL (as As. Cancer hazard - see 2 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorgani compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) France - VME: 0.2 mg/m3 VME (as As) Germany: 0.1 mg/m3 TWA (inhalable fraction) Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere value, as As) Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine) Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As) Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As) Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As) Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As) Spain: 0.1 mg/m3 VLA-ED (as As) CAS# 7697-37-2: United Kingdom, WEL - TWA: 2 ppm TWA; 5.2 mg/m3 TWA United Kingdom, WEL - STEL: 4 ppm STEL; 10 mg/m3 STEL United States OSHA: 2 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 2 ppm VLE; 5.3 mg/m3 VLE Belgium - STEL: 4 ppm VLE; 10 mg/m3 VLE France - VME: 2 ppm VME; 5 mg/m3 VME France - VLE: 4 ppm VLE; 10 mg/m3 VLE Germany: 2 ppm TWA; 5.2 mg/m3 TWA Japan: 2 ppm OEL; 5.2 mg/m3 OEL Malaysia: 2 ppm TWA; 5.2 mg/m3 TWA Netherlands: 0.5 ppm STEL; 1.3 mg/m3 STEL Russia: 2 mg/m3 TWA Spain: 2 ppm VLA-ED; 5.2 mg/m3 VLA-ED Spain: 4 ppm VLA-EC; 10 mg/m3 VLA-EC CAS# 7732-18-5: CAS# 7778-39-4: Germany: 0.1 mg/m3 TWA (inhalable fraction) Spain: 0.1 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits CAS# 1327-53-3: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As) United States OSHA: 0.5 mg/m3 TWA (listed under Arsenic).5 ??g/m3 Action Level (as As); 10 ??g/m3 PEL (as As. Cancer hazard - see 2 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorgani compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) France - VME: 0.2 mg/m3 VME (as As) Germany: 0.1 mg/m3 TWA (inhalable fraction) Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere value, as As) Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine) Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As) Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As) Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As) Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As) Spain: 0.1 mg/m3 VLA-ED (as As) CAS# 7697-37-2: United Kingdom, WEL - TWA: 2 ppm TWA; 5.2 mg/m3 TWA United Kingdom, WEL - STEL: 4 ppm STEL; 10 mg/m3 STEL United States OSHA: 2 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 2 ppm VLE; 5.3 mg/m3 VLE Belgium - STEL: 4 ppm VLE; 10 mg/m3 VLE France - VME: 2 ppm VME; 5 mg/m3 VME France - VLE: 4 ppm VLE; 10 mg/m3 VLE Germany: 2 ppm TWA; 5.2 mg/m3 TWA Japan: 2 ppm OEL; 5.2 mg/m3 OEL Malaysia: 2 ppm TWA; 5.2 mg/m3 TWA Netherlands: 0.5 ppm STEL; 1.3 mg/m3 STEL Russia: 2 mg/m3 TWA Spain: 2 ppm VLA-ED; 5.2 mg/m3 VLA-ED Spain: 4 ppm VLA-EC; 10 mg/m3 VLA-EC CAS# 7732-18-5: CAS# 7778-39-4: Germany: 0.1 mg/m3 TWA (inhalable fraction) Spain: 0.1 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Acidic
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: Not available.
Molecular Formula: Solution
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. The yellow color is due to release of nitrogen dioxide on exposure to light.
Conditions to Avoid:
High temperatures, light, confined spaces.
Incompatibilities with Other Materials:
Metals, strong reducing agents, strong bases.
Hazardous Decomposition Products:
Oxides of nitrogen, oxides of arsenic.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures. The yellow color is due to release of nitrogen dioxide on exposure to light.
Conditions to Avoid:
High temperatures, light, confined spaces.
Incompatibilities with Other Materials:
Metals, strong reducing agents, strong bases.
Hazardous Decomposition Products:
Oxides of nitrogen, oxides of arsenic.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1327-53-3: CG3325000 CAS# 7697-37-2: QU5775000 QU5900000 CAS# 7732-18-5: ZC0110000 CAS# 7778-39-4: CG0700000 LD50/LC50:
CAS# 1327-53-3: Oral, mouse: LD50 = 20 mg/kg; Oral, rabbit: LD50 = 20190 ug/kg; Oral, rat: LD50 = 10 mg/kg.
CAS# 7697-37-2: Inhalation, rat: LC50 = 260 mg/m3/30M; Inhalation, rat: LC50 = 130 mg/m3/4H; Inhalation, rat: LC50 = 67 ppm(NO2)/4H.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 7778-39-4: Oral, rat: LD50 = 48 mg/kg.
Carcinogenicity:
Arsenic trioxide - California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic).
Nitric acid - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Arsenic acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 1327-53-3: CG3325000 CAS# 7697-37-2: QU5775000 QU5900000 CAS# 7732-18-5: ZC0110000 CAS# 7778-39-4: CG0700000 LD50/LC50:
CAS# 1327-53-3: Oral, mouse: LD50 = 20 mg/kg; Oral, rabbit: LD50 = 20190 ug/kg; Oral, rat: LD50 = 10 mg/kg.
CAS# 7697-37-2: Inhalation, rat: LC50 = 260 mg/m3/30M; Inhalation, rat: LC50 = 130 mg/m3/4H; Inhalation, rat: LC50 = 67 ppm(NO2)/4H.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 7778-39-4: Oral, rat: LD50 = 48 mg/kg.
Carcinogenicity:
Arsenic trioxide - California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic).
Nitric acid - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Arsenic acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: CORROSIVE LIQUID, ACIDIC, INORGANIC, NOS(Nitric ac
id solution)
Hazard Class: 8
UN Number: 3264
Packing Group: III
IMO
Shipping Name: CORROSIVE LIQUID, ACIDIC, INORGANIC, NOS(Nitric ac
id solution)
Hazard Class: 8
UN Number: 3264
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE LIQUID, ACIDIC, INORGANIC, NOS(Nitric ac
id solution)
Hazard Class: 8
UN Number: 3264
Packing group: III
USA RQ: CAS# 1327-53-3: 1 lb final RQ; 0.454 kg final RQ
USA RQ: CAS# 7697-37-2: 1000 lb final RQ; 454 kg final RQ
USA RQ: CAS# 7778-39-4: 1 lb final RQ; 0.454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN N
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 20/21 When using do not eat, drink or smoke.
S 28 After contact with skin, wash immediately
with...
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1327-53-3: 3
CAS# 7697-37-2: 1
CAS# 7732-18-5: No information available.
CAS# 7778-39-4: 3
Canada
CAS# 1327-53-3 is listed on Canadas DSL List.
CAS# 7697-37-2 is listed on Canadas DSL List.
CAS# 7732-18-5 is listed on Canadas DSL List.
CAS# 7778-39-4 is listed on Canadas DSL List.
CAS# 1327-53-3 is listed on Canadas Ingredient Disclosure List.
CAS# 7697-37-2 is listed on Canadas Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 7778-39-4 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1327-53-3 is listed on the TSCA inventory.
CAS# 7697-37-2 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 7778-39-4 is listed on the TSCA inventory.
