Name:
Arsenic(V) oxide
Synonym:
Arsenic pentoxide; Diarsenic pentaoxide; Arsenic acid anhydride; Arsenic anhydride
CAS:
1303-28-2
Section 1 - Chemical Product
MSDS Name:Arsenic(V) oxide
Synonym:Arsenic pentoxide; Diarsenic pentaoxide; Arsenic acid anhydride; Arsenic anhydride
Synonym:Arsenic pentoxide; Diarsenic pentaoxide; Arsenic acid anhydride; Arsenic anhydride
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 1303-28-2 | Arsenic(V) oxide | >99.9 | 215-116-9 |
| Hazard Symbols: T N Risk Phrases: 23/25 45 50/53 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. May cause cancer. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May result in corneal injury.
Skin:
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
May cause liver damage. Can cause nervous system damage. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. All soluble arsenic (As) compounds are considered to be poisonous to humans.
Inorganic arsenic is more toxic than organic arsenic. Organic arsenic is excreted more rapidly than inorganic arsenic. Arsenic 5+ is excreted more rapidly than arsenic 3+. Arsenic inhibits enzymes required for cellular respiration and also competes with phosphorus for incorporation into ATP, depleting cellular energy stores and leading to cell death.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation.
Chronic:
Chronic ingestion is characterized by weakness, anorexia, gastrointestinal disturbances, impairment of cognitive function, peripheral neuropathy, and skin disorders. Chronic ingestion may cause fetal effects. Inorganic arsenic compounds may cause skin and lung cancers in humans.
Toxic by inhalation and if swallowed. May cause cancer. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May result in corneal injury.
Skin:
May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
May cause liver damage. Can cause nervous system damage. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. All soluble arsenic (As) compounds are considered to be poisonous to humans.
Inorganic arsenic is more toxic than organic arsenic. Organic arsenic is excreted more rapidly than inorganic arsenic. Arsenic 5+ is excreted more rapidly than arsenic 3+. Arsenic inhibits enzymes required for cellular respiration and also competes with phosphorus for incorporation into ATP, depleting cellular energy stores and leading to cell death.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation.
Chronic:
Chronic ingestion is characterized by weakness, anorexia, gastrointestinal disturbances, impairment of cognitive function, peripheral neuropathy, and skin disorders. Chronic ingestion may cause fetal effects. Inorganic arsenic compounds may cause skin and lung cancers in humans.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray to cool fire-exposed containers.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray to cool fire-exposed containers.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with adequate ventilation or respiratory protection.
Storage:
Poison room locked.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with adequate ventilation or respiratory protection.
Storage:
Poison room locked.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits CAS# 1303-28-2: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As) United States OSHA: 5 ??g/m3 Action Level (as As); 10 ??g/m3 PEL (a As. Cancer hazard - see 29 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorganic compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) Germany: 0.1 mg/m3 TWA (inhalable fraction) Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere value, as As) Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine) Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As) Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As) Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As) Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As) Spain: 0.1 mg/m3 VLA-ED (as As) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic.
Exposure Limits CAS# 1303-28-2: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As) United States OSHA: 5 ??g/m3 Action Level (as As); 10 ??g/m3 PEL (a As. Cancer hazard - see 29 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorganic compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) Germany: 0.1 mg/m3 TWA (inhalable fraction) Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere value, as As) Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine) Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As) Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As) Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As) Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As) Spain: 0.1 mg/m3 VLA-ED (as As) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: white
Odor: odorless
pH: acidic in soln
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 315 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 315 deg C
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: As2O5
Molecular Weight: 229.84
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, moist air.
Incompatibilities with Other Materials:
Acids, aluminum, halogens, zinc, rubidium carbide.
Hazardous Decomposition Products:
Oxides of arsenic.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, moist air.
Incompatibilities with Other Materials:
Acids, aluminum, halogens, zinc, rubidium carbide.
Hazardous Decomposition Products:
Oxides of arsenic.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1303-28-2: CG2275000 LD50/LC50:
CAS# 1303-28-2: Oral, mouse: LD50 = 55 mg/kg; Oral, rat: LD50 = 8 mg/kg.
Carcinogenicity:
Arsenic(V) oxide - California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic compounds, n.o.s.).
Other:
See actual entry in RTECS for complete information.
CAS# 1303-28-2: CG2275000 LD50/LC50:
CAS# 1303-28-2: Oral, mouse: LD50 = 55 mg/kg; Oral, rat: LD50 = 8 mg/kg.
Carcinogenicity:
Arsenic(V) oxide - California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic compounds, n.o.s.).
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing Group: II
IMO
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing Group: II
RID/ADR
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing group: II
USA RQ: CAS# 1303-28-2: 1 lb final RQ; 0.454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 23/25 Toxic by inhalation and if swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1303-28-2: 3
Canada
CAS# 1303-28-2 is listed on Canadas DSL List.
CAS# 1303-28-2 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1303-28-2 is listed on the TSCA inventory.
