Name:
Biuret Reagent Solution
Synonym:
None Known
CAS:
1310-73-2
Section 1 - Chemical Product
MSDS Name:Biuret Reagent Solution
Synonym:None Known
Synonym:None Known
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 1310-73-2 | Sodium hydroxide | 10.0 | 215-185-5 |
| Hazard Symbols: C Risk Phrases: 34 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause deep, penetrating ulcers of the skin.
May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Effects may be delayed. Individuals with Wilsons disease are unable to metabolize copper. Thus, copper accumulates in various tissues and may result in liver, kidney, and brain damage.
Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause deep, penetrating ulcers of the skin.
May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Effects may be delayed. Individuals with Wilsons disease are unable to metabolize copper. Thus, copper accumulates in various tissues and may result in liver, kidney, and brain damage.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to extinguish surrounding fire.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to extinguish surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Use only in a well-ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1310-73-2: United Kingdom, WEL - STEL: 2 mg/m3 STEL United States OSHA: 2 mg/m3 TWA Belgium - TWA: 2 mg/m3 VLE France - VME: 2 mg/m3 VME Germany: 2 mg/m3 TWA (inhalable fraction) Japan: 2 mg/m3 Ceiling Malaysia: 2 mg/m3 Ceiling Spain: 2 mg/m3 VLA-EC CAS# 6381-59-5: CAS# 7732-18-5: CAS# 7758-99-8: United Kingdom, WEL - TWA: (listed as copper): 0.2 mg/m3 TWA (fum 1 mg/m3 TWA (dust and mist) United Kingdom, WEL - STEL: (listed as copper): 0.6 mg/m3 STEL (fume); 2 mg/m3 STEL (dust and mist) United States OSHA: 0.1 mg/m3 TWA (fume); 1 mg/m3 TWA (dusts and mists) (listed under Copper).
Belgium - TWA: (listed as copper): 0.2 mg/m3 VLE (fume); 1 mg/m3 (dust and mist) France - VME: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 V (dust, as Cu) France - VLE: (listed as copper): 2 mg/m3 VLE (dust, as Cu) Germany: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 VME (d as Cu) Malaysia: (listed as copper): 0.2 mg/m3 TWA (fume, as Cu); 1 mg/m TWA (dust and mist, as Cu) Netherlands: (listed as copper): 0.2 mg/m3 MAC (smoke); 1 mg/m3 M (dust) Russia: (listed as copper): 1 mg/m3 TWA (dust) Russia: (listed as copper): 0.5 mg/m3 STEL (dust) Spain: (listed as copper): 0.2 mg/m3 VLA-ED (fume); 1 mg/m3 VLA-E (dust and mist, as Cu) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1310-73-2: United Kingdom, WEL - STEL: 2 mg/m3 STEL United States OSHA: 2 mg/m3 TWA Belgium - TWA: 2 mg/m3 VLE France - VME: 2 mg/m3 VME Germany: 2 mg/m3 TWA (inhalable fraction) Japan: 2 mg/m3 Ceiling Malaysia: 2 mg/m3 Ceiling Spain: 2 mg/m3 VLA-EC CAS# 6381-59-5: CAS# 7732-18-5: CAS# 7758-99-8: United Kingdom, WEL - TWA: (listed as copper): 0.2 mg/m3 TWA (fum 1 mg/m3 TWA (dust and mist) United Kingdom, WEL - STEL: (listed as copper): 0.6 mg/m3 STEL (fume); 2 mg/m3 STEL (dust and mist) United States OSHA: 0.1 mg/m3 TWA (fume); 1 mg/m3 TWA (dusts and mists) (listed under Copper).
Belgium - TWA: (listed as copper): 0.2 mg/m3 VLE (fume); 1 mg/m3 (dust and mist) France - VME: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 V (dust, as Cu) France - VLE: (listed as copper): 2 mg/m3 VLE (dust, as Cu) Germany: (listed as copper): 0.2 mg/m3 VME (fume); 1 mg/m3 VME (d as Cu) Malaysia: (listed as copper): 0.2 mg/m3 TWA (fume, as Cu); 1 mg/m TWA (dust and mist, as Cu) Netherlands: (listed as copper): 0.2 mg/m3 MAC (smoke); 1 mg/m3 M (dust) Russia: (listed as copper): 1 mg/m3 TWA (dust) Russia: (listed as copper): 0.5 mg/m3 STEL (dust) Spain: (listed as copper): 0.2 mg/m3 VLA-ED (fume); 1 mg/m3 VLA-E (dust and mist, as Cu) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear blue
Odor: odorless
pH: Alkaline
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 212 deg F
Freezing/Melting Point: 32 deg F
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.0
Molecular Formula: Solution
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, acids.
Incompatibilities with Other Materials:
Acetaldehyde, acrolein, acrylonitrile, allyl alcohol, aluminum, chlorine trifluoride, halogenated organics (e.g. dibromoethane, hexachlorobenzene, methyl chloride, trichloroethylene), maleic anhydride, metals, nitromethane, nitroparaffins, nitropropane, phenols, phosphorus pentoxide, tetrahydrofuran.
Hazardous Decomposition Products:
Oxides of sulfur, sodium peroxide fumes, sodium oxide, oxides of potassium.
Hazardous Polymerization: Has not been reported
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, acids.
Incompatibilities with Other Materials:
Acetaldehyde, acrolein, acrylonitrile, allyl alcohol, aluminum, chlorine trifluoride, halogenated organics (e.g. dibromoethane, hexachlorobenzene, methyl chloride, trichloroethylene), maleic anhydride, metals, nitromethane, nitroparaffins, nitropropane, phenols, phosphorus pentoxide, tetrahydrofuran.
Hazardous Decomposition Products:
Oxides of sulfur, sodium peroxide fumes, sodium oxide, oxides of potassium.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1310-73-2: WB4900000 CAS# 6381-59-5 unlisted.
CAS# 7732-18-5: ZC0110000 CAS# 7758-99-8: GL8900000 LD50/LC50:
CAS# 1310-73-2: Draize test, rabbit, eye: 400 ug Mild; Draize test, rabbit, eye: 1% Severe; Draize test, rabbit, eye: 50 ug/24H Severe; Draize test, rabbit, eye: 1 mg/24H Severe; Draize test, rabbit, skin: 500 mg/24H Severe.
CAS# 6381-59-5.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 7758-99-8: Oral, mouse: LD50 = 43 mg/kg; Oral, rat: LD50 = 300 mg/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
Sodium hydroxide - Not listed by ACGIH, IARC, or NTP.
Butanedioic acid, 2,3-dihydroxy- [r-(r*,r*)]-, monopotassium - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Copper (ii) sulfate pentahydrate (1:1:5) - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 1310-73-2: WB4900000 CAS# 6381-59-5 unlisted.
CAS# 7732-18-5: ZC0110000 CAS# 7758-99-8: GL8900000 LD50/LC50:
CAS# 1310-73-2: Draize test, rabbit, eye: 400 ug Mild; Draize test, rabbit, eye: 1% Severe; Draize test, rabbit, eye: 50 ug/24H Severe; Draize test, rabbit, eye: 1 mg/24H Severe; Draize test, rabbit, skin: 500 mg/24H Severe.
CAS# 6381-59-5.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 7758-99-8: Oral, mouse: LD50 = 43 mg/kg; Oral, rat: LD50 = 300 mg/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
Sodium hydroxide - Not listed by ACGIH, IARC, or NTP.
Butanedioic acid, 2,3-dihydroxy- [r-(r*,r*)]-, monopotassium - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Copper (ii) sulfate pentahydrate (1:1:5) - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Pseudomonas putida:
Fish: Pseudomonas putida:
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 1310-73-2: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 25 Avoid contact with eyes.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1310-73-2: 1
CAS# 6381-59-5: 0
CAS# 7732-18-5: No information available.
CAS# 7758-99-8: 2
Canada
CAS# 1310-73-2 is listed on Canadas DSL List.
CAS# 7732-18-5 is listed on Canadas DSL List.
CAS# 1310-73-2 is listed on Canadas Ingredient Disclosure List.
CAS# 6381-59-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 7758-99-8 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1310-73-2 is listed on the TSCA inventory.
CAS# 6381-59-5 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 7758-99-8 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).
