Name:
Chloroform ECD Tested for Pesticide Analysis Residue
Synonym:
Formyl Trichloride; Methane Trichloride; Methane, Trichloro-; Methenyl Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform; Trichloromethane
CAS:
67-66-3
Section 1 - Chemical Product
MSDS Name:Chloroform ECD Tested for Pesticide Analysis Residue
Synonym:Formyl Trichloride; Methane Trichloride; Methane, Trichloro-; Methenyl Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform; Trichloromethane
Synonym:Formyl Trichloride; Methane Trichloride; Methane, Trichloro-; Methenyl Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform; Trichloromethane
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-66-3 | Chloroform | >99.9 | 200-663-8 |
| Hazard Symbols: XN Risk Phrases: |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to skin. Limited evidence of a carcinogenic effect. Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.Light sensitive.
Potential Health Effects
Eye:
Causes moderate eye irritation. Contact with liquid causes immediate burning pain, tearing, and reddening of the conjunctiva.
Skin:
Causes mild skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause cardiac disturbances.
Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Possible aspiration hazard. May cause hallucinations and distorted perceptions.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause cardiac sensitization and possible failure.
Inhalation of large amounts may cause respiratory stimulation, followed by respiratory depression, convulsions and possible death due to respiratory paralysis. May be absorbed through the lungs.
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Toxicity may be increased by exposure to alcohol, steroids, and ketones. Prolonged exposure may cause liver, kidney, and heart damage.
Harmful if swallowed. Irritating to skin. Limited evidence of a carcinogenic effect. Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.Light sensitive.
Potential Health Effects
Eye:
Causes moderate eye irritation. Contact with liquid causes immediate burning pain, tearing, and reddening of the conjunctiva.
Skin:
Causes mild skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause cardiac disturbances.
Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Possible aspiration hazard. May cause hallucinations and distorted perceptions.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause cardiac sensitization and possible failure.
Inhalation of large amounts may cause respiratory stimulation, followed by respiratory depression, convulsions and possible death due to respiratory paralysis. May be absorbed through the lungs.
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Toxicity may be increased by exposure to alcohol, steroids, and ketones. Prolonged exposure may cause liver, kidney, and heart damage.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product. Alcoholic beverage consumption may enhance the toxic effects of this substance. Effects may be delayed.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product. Alcoholic beverage consumption may enhance the toxic effects of this substance. Effects may be delayed.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Substance is nonflammable. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Do NOT get water inside containers. Do NOT use straight streams of water. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Substance is nonflammable. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Do NOT get water inside containers. Do NOT use straight streams of water. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Do not ingest or inhale. Store protected from light.
Storage:
Do not store in direct sunlight. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from acids. Do not store near alkaline substances. Separate from strong mineral acids.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Do not ingest or inhale. Store protected from light.
Storage:
Do not store in direct sunlight. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from acids. Do not store near alkaline substances. Separate from strong mineral acids.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear, colorless
Odor: sweet, fruity odor - ethereal odor
pH: Not available.
Vapor Pressure: 160 mm Hg @ 20 deg C
Viscosity: 0.58 cps @ 20 deg C
Boiling Point: 60.5-61.5 deg C
Freezing/Melting Point: -63 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.492 (Water=1)
Molecular Formula: CHCl3
Molecular Weight: 119.366
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Light sensitive.
Conditions to Avoid:
High temperatures, incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents, aluminum, fluorine, magnesium, sodium potassium, lithium, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), dinitrogen tetraoxide, sodium + methanol, potassium-tert-butoxide, chemically active metals, Attacks some forms of plastics, rubbers, and coatings., nitrogen tetroxide, acetone + alkali, disilane, perchloric acid + phosphorus pentoxide, sodium methylate, triisopropylphosphine, sodium methoxide + methanol.
Hazardous Decomposition Products:
Hydrogen chloride, irritating and toxic fumes and gases, carbon dioxide, chlorine, phosgene gas.
Hazardous Polymerization: Will not occur.
Stable at room temperature in closed containers under normal storage and handling conditions. Light sensitive.
Conditions to Avoid:
High temperatures, incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents, aluminum, fluorine, magnesium, sodium potassium, lithium, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), dinitrogen tetraoxide, sodium + methanol, potassium-tert-butoxide, chemically active metals, Attacks some forms of plastics, rubbers, and coatings., nitrogen tetroxide, acetone + alkali, disilane, perchloric acid + phosphorus pentoxide, sodium methylate, triisopropylphosphine, sodium methoxide + methanol.
Hazardous Decomposition Products:
Hydrogen chloride, irritating and toxic fumes and gases, carbon dioxide, chlorine, phosgene gas.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-66-3: FS9100000 CAS# 25377-72-4 unlisted.
LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 47702 mg/m3/4H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg; Skin, rabbit: LD50 = >20 gm/kg.
CAS# 25377-72-4.
Carcinogenicity:
Chloroform - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Amylene - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 67-66-3: FS9100000 CAS# 25377-72-4 unlisted.
LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 47702 mg/m3/4H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg; Skin, rabbit: LD50 = >20 gm/kg.
CAS# 25377-72-4.
Carcinogenicity:
Chloroform - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Amylene - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Channel catfish: LC50 = 75 ppm; 96 Hr; UnspecifiedFish: Rainbow trout: LC50 = 43.8 mg/L; 96 Hr; Static bioassayFish: Fathead Minnow: LC50 = 129.0 mg/L; 96 Hr; Static bioassay (pH = 7.6-8.3)Fish: Bluegill/Sunfish: LC50 = 100.0 mg/L; 96 Hr; Static bioassayWater flea Daphnia: EC50 = 28.9 mg/L; 48 Hr; Static bioassayThe majority of the environmental releases from industrial uses are to the atmosphere; releases to water and land will be primarily lost by evaporation and will end up in the atmosphere. Release to the atmosphere may be transported long distances and will photodegrade with a half-life of a few months. Spills and other releases on land
Fish: Channel catfish: LC50 = 75 ppm; 96 Hr; UnspecifiedFish: Rainbow trout: LC50 = 43.8 mg/L; 96 Hr; Static bioassayFish: Fathead Minnow: LC50 = 129.0 mg/L; 96 Hr; Static bioassay (pH = 7.6-8.3)Fish: Bluegill/Sunfish: LC50 = 100.0 mg/L; 96 Hr; Static bioassayWater flea Daphnia: EC50 = 28.9 mg/L; 48 Hr; Static bioassayThe majority of the environmental releases from industrial uses are to the atmosphere; releases to water and land will be primarily lost by evaporation and will end up in the atmosphere. Release to the atmosphere may be transported long distances and will photodegrade with a half-life of a few months. Spills and other releases on land
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 38 Irritating to skin.
R 40 Limited evidence of a carcinogenic effect.
R 48/20/22 Harmful : danger of serious damage to
health by prolonged exposure through inhalation and if
swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 67-66-3: 3
CAS# 25377-72-4: No information available.
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 67-66-3 is not listed on Canadas Ingredient Disclosure List.
CAS# 25377-72-4 is not listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 67-66-3: OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3)
OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Carcinogen
OEL-AUSTRIA:TWA 10 ppm (50 mg/m3)
OEL-BELGIUM:TWA 10 ppm (49 mg/m3);Carcinogen JAN9
OEL-CZECHOSLOVAKIA:TWA 10 mg/m3;STEL 20 mg/m3
OEL-DENMARK:TWA 2 ppm (10 mg/m3);Carcinogen
OEL-FINLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm;Skin;CAR
OEL-FRANCE:TWA 5 ppm (25 mg/m3);STEL 50 ppm (250 mg/m3);CAR
OEL-GERMANY:TWA 10 ppm (50 mg/m3);Carcinogen JAN9
OEL-HUNGARY:STEL 10 mg/m3
OEL-INDIA:TWA 10 ppm (50 mg/m3);Carcinogen
OEL-JAPAN:TWA 50 ppm (240 mg/m3);Carcinogen
OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3)
OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3)
OEL-POLAND:TWA 50 mg/m3
OEL-RUSSIA:TWA 50 ppm
OEL-SWEDEN:TWA 2 ppm (10 mg/m3);STEL 5 ppm (25 mg/m3);CAR
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3)
OEL-THAILAND:TWA 50 ppm (240 mg/m3)
OEL-TURKEY:TWA 50 ppm (240 mg/m3)
OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);STEL 50 ppm (225 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 67-66-3 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 25377-72-4 is not listed on the TSCA inventory.
It is for research and development use only.
