Name:
Chloroform/Isoamyl alcohol DNase RNase and Protease free (24 parts
Synonym:
None
CAS:
67-66-3
Section 1 - Chemical Product
MSDS Name:Chloroform/Isoamyl alcohol DNase RNase and Protease free (24 parts
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-66-3 | Chloroform | 97.8 | 200-663-8 |
| Hazard Symbols: XN Risk Phrases: 10 22 38 40 48/20/22 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Harmful if swallowed. Irritating to skin. Limited evidence of a carcinogenic effect. Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.
Flammable. Harmful if swallowed. Irritating to skin. Limited evidence of a carcinogenic effect. Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Flammable liquid and vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Flammable liquid and vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.
Section 7 - HANDLING and STORAGE
Handling:
Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Flammables-area.
Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 67-66-3: United Kingdom, WEL - TWA: 2 ppm TWA; 9.9 mg/m3 TWA United Kingdom, WEL - STEL: 6 ppm STEL; 29.7 mg/m3 STEL United States OSHA: ; 50 ppm Ceiling; 240 mg/m3 Ceiling Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE France - VME: 5 ppm VME; 25 mg/m3 VME France - VLE: 50 ppm VLE; 250 mg/m3 VLE Germany: 4 ppm TWA (large technical manufacture and use); 20 mg/m TWA (large technical m Germany: Skin absorber Japan: 10 ppm OEL; 49 mg/m3 OEL Malaysia: 10 ppm TWA; 49 mg/m3 TWA Netherlands: 5 ppm STEL; 25 mg/m3 STEL Netherlands: 1 ppm MAC; 5 mg/m3 MAC Spain: 2 ppm VLA-ED; 10 mg/m3 VLA-ED CAS# 123-51-3: United Kingdom, WEL - TWA: 100 ppm TWA; 366 mg/m3 TWA United Kingdom, WEL - STEL: 125 ppm STEL; 458 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 100 ppm VLE; 366 mg/m3 VLE Belgium - STEL: 125 ppm VLE; 459 mg/m3 VLE France - VME: 100 ppm VME; 360 mg/m3 VME Germany: 100 ppm TWA; 370 mg/m3 TWA Japan: 100 ppm OEL; 360 mg/m3 OEL Malaysia: 100 ppm TWA; 361 mg/m3 TWA Netherlands: 100 ppm MAC; 360 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 100 ppm VLA-ED; 366 mg/m3 VLA-ED Spain: 125 ppm VLA-EC; 458 mg/m3 VLA-EC Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 67-66-3: United Kingdom, WEL - TWA: 2 ppm TWA; 9.9 mg/m3 TWA United Kingdom, WEL - STEL: 6 ppm STEL; 29.7 mg/m3 STEL United States OSHA: ; 50 ppm Ceiling; 240 mg/m3 Ceiling Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE France - VME: 5 ppm VME; 25 mg/m3 VME France - VLE: 50 ppm VLE; 250 mg/m3 VLE Germany: 4 ppm TWA (large technical manufacture and use); 20 mg/m TWA (large technical m Germany: Skin absorber Japan: 10 ppm OEL; 49 mg/m3 OEL Malaysia: 10 ppm TWA; 49 mg/m3 TWA Netherlands: 5 ppm STEL; 25 mg/m3 STEL Netherlands: 1 ppm MAC; 5 mg/m3 MAC Spain: 2 ppm VLA-ED; 10 mg/m3 VLA-ED CAS# 123-51-3: United Kingdom, WEL - TWA: 100 ppm TWA; 366 mg/m3 TWA United Kingdom, WEL - STEL: 125 ppm STEL; 458 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 100 ppm VLE; 366 mg/m3 VLE Belgium - STEL: 125 ppm VLE; 459 mg/m3 VLE France - VME: 100 ppm VME; 360 mg/m3 VME Germany: 100 ppm TWA; 370 mg/m3 TWA Japan: 100 ppm OEL; 360 mg/m3 OEL Malaysia: 100 ppm TWA; 361 mg/m3 TWA Netherlands: 100 ppm MAC; 360 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 100 ppm VLA-ED; 366 mg/m3 VLA-ED Spain: 125 ppm VLA-EC; 458 mg/m3 VLA-EC Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Clear solution
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 43 deg C ( 109.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-66-3: FS9100000 CAS# 123-51-3: EL5425000 LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 148 mg; Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 17200 mg/m3/2H; Inhalation, mouse: LC50 = 6000 mg/m3/6H; Inhalation, rat: LC50 = 47702 mg/m3/4H; Inhalation, rat: LC50 = 6000 mg/m3/6H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg; Oral, rat: LD50 = 1250 mg/kg; Skin, rabbit: LD50 = >20 gm/kg.
CAS# 123-51-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Oral, rabbit: LD50 = 3438 mg/kg; Oral, rat: LD50 = 1300 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = 3970 uL/kg.
Carcinogenicity:
Chloroform - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 10/1/87 NTP: Suspect carcinogen IARC: Group 2B carcinogen Isoamyl alcohol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 67-66-3: FS9100000 CAS# 123-51-3: EL5425000 LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 148 mg; Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 17200 mg/m3/2H; Inhalation, mouse: LC50 = 6000 mg/m3/6H; Inhalation, rat: LC50 = 47702 mg/m3/4H; Inhalation, rat: LC50 = 6000 mg/m3/6H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg; Oral, rat: LD50 = 1250 mg/kg; Skin, rabbit: LD50 = >20 gm/kg.
CAS# 123-51-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Oral, rabbit: LD50 = 3438 mg/kg; Oral, rat: LD50 = 1300 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = 3970 uL/kg.
Carcinogenicity:
Chloroform - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 10/1/87 NTP: Suspect carcinogen IARC: Group 2B carcinogen Isoamyl alcohol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: FLAMMABLE LIQUID, TOXIC, N.O.S.*
Hazard Class: 3 (6.1)
UN Number: 1992
Packing Group: III
IMO
Shipping Name: FLAMMABLE LIQUID, TOXIC, N.O.S.
Hazard Class: 3.3
UN Number: 1992
Packing Group: III
RID/ADR
Shipping Name: FLAMMABLE LIQUID, TOXIC, N.O.S.
Hazard Class: 3
UN Number: 1992
Packing group: III
USA RQ: CAS# 67-66-3: 10 lb final RQ; 4.54 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 22 Harmful if swallowed.
R 38 Irritating to skin.
R 40 Limited evidence of a carcinogenic effect.
R 48/20/22 Harmful : danger of serious damage to
health by prolonged exposure through inhalation and if
swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 67-66-3: 3
CAS# 123-51-3: 1
Canada
CAS# 67-66-3 is listed on Canadas DSL List.
CAS# 123-51-3 is listed on Canadas DSL List.
CAS# 67-66-3 is listed on Canadas Ingredient Disclosure List.
CAS# 123-51-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-66-3 is listed on the TSCA inventory.
CAS# 123-51-3 is listed on the TSCA inventory.
