Name:
Dimethyl Sulfate
Synonym:
Methyl sulfate; DMS; Dimethyl monosulfate
CAS:
77-78-1
Section 1 - Chemical Product
MSDS Name:Dimethyl Sulfate
Synonym:Methyl sulfate; DMS; Dimethyl monosulfate
Synonym:Methyl sulfate; DMS; Dimethyl monosulfate
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 77-78-1 | Dimethyl sulfate | > 99 | 201-058-1 |
| Hazard Symbols: T+ C Risk Phrases: 25 26 34 43 45 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic if swallowed. Very toxic by inhalation. Causes burns. May cause sensitization by skin contact. May cause cancer.Moisture sensitive.
Potential Health Effects
Eye:
Causes eye burns. May cause irreversible eye injury.
Skin:
Causes skin burns. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns. Effects may be delayed 2 to 4 hours.
Inhalation:
May be fatal if inhaled. Effects may be delayed. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause lung damage. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
May cause liver and kidney damage. May cause cancer in humans. May cause reproductive and fetal effects.
Toxic if swallowed. Very toxic by inhalation. Causes burns. May cause sensitization by skin contact. May cause cancer.Moisture sensitive.
Potential Health Effects
Eye:
Causes eye burns. May cause irreversible eye injury.
Skin:
Causes skin burns. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns. Effects may be delayed 2 to 4 hours.
Inhalation:
May be fatal if inhaled. Effects may be delayed. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause lung damage. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
May cause liver and kidney damage. May cause cancer in humans. May cause reproductive and fetal effects.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Contact with metals may evolve flammable hydrogen gas.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. For small fires, use dry chemical, carbon dioxide, sand, earth, water spray or regular foam. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Contact with metals may evolve flammable hydrogen gas.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. For small fires, use dry chemical, carbon dioxide, sand, earth, water spray or regular foam. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Corrosives area. Do not store in metal containers.
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Corrosives area. Do not store in metal containers.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 77-78-1: United Kingdom, WEL - TWA: 0.05 ppm TWA; 0.26 mg/m3 TWA United Kingdom, WEL - STEL: 0.15 ppm STEL; 0.78 mg/m3 STEL United States OSHA: 1 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 0.1 ppm VLE; 0.53 mg/m3 VLE France - VME: 0.1 ppm VME; 0.5 mg/m3 VME Germany: 0.02 ppm TWA (manufacture); 0.1 mg/m3 TWA (manufacture); 0.04 ppm TWA (use); 0.2 Germany: Skin absorber Japan: 0.1 ppm OEL; 0.52 mg/m3 OEL Malaysia: 0.1 ppm TWA; 0.52 mg/m3 TWA Russia: 0.1 mg/m3 TWA Spain: 0.05 ppm VLA-ED; 0.26 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 77-78-1: United Kingdom, WEL - TWA: 0.05 ppm TWA; 0.26 mg/m3 TWA United Kingdom, WEL - STEL: 0.15 ppm STEL; 0.78 mg/m3 STEL United States OSHA: 1 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 0.1 ppm VLE; 0.53 mg/m3 VLE France - VME: 0.1 ppm VME; 0.5 mg/m3 VME Germany: 0.02 ppm TWA (manufacture); 0.1 mg/m3 TWA (manufacture); 0.04 ppm TWA (use); 0.2 Germany: Skin absorber Japan: 0.1 ppm OEL; 0.52 mg/m3 OEL Malaysia: 0.1 ppm TWA; 0.52 mg/m3 TWA Russia: 0.1 mg/m3 TWA Spain: 0.05 ppm VLA-ED; 0.26 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear to slightly hazy
Odor: faint odor
pH: Not available.
Vapor Pressure: 0.5 mm Hg @ 20C
Viscosity: Not available.
Boiling Point: 188 deg C (decomposes)
Freezing/Melting Point: -32 deg C
Autoignition Temperature: 495 deg C ( 923.00 deg F)
Flash Point: 83 deg C ( 181.40 deg F)
Explosion Limits, lower: 3.6
Explosion Limits, upper: 23.2
Decomposition Temperature: 188 deg C
Solubility in water: Slightly soluble in water.
Specific Gravity/Density: 1.33
Molecular Formula: C2H6O4S
Molecular Weight: 126.13
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, mechanical shock, ignition sources, metals, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, ammonia, and moist air or water. Can react violently with ammonium hydroxide and sodium azide.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, mechanical shock, ignition sources, metals, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, ammonia, and moist air or water. Can react violently with ammonium hydroxide and sodium azide.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 77-78-1: WS8225000 LD50/LC50:
CAS# 77-78-1: Draize test, rabbit, eye: 50 ug/24H Severe; Inhalation, mouse: LC50 = 280 mg/m3; Inhalation, rat: LC50 = 45 mg/m3/4H; Oral, mouse: LD50 = 140 mg/kg; Oral, rat: LD50 = 205 mg/kg.
Carcinogenicity:
Dimethyl sulfate - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2A carcinogen Other:
See actual entry in RTECS for complete information.
CAS# 77-78-1: WS8225000 LD50/LC50:
CAS# 77-78-1: Draize test, rabbit, eye: 50 ug/24H Severe; Inhalation, mouse: LC50 = 280 mg/m3; Inhalation, rat: LC50 = 45 mg/m3/4H; Oral, mouse: LD50 = 140 mg/kg; Oral, rat: LD50 = 205 mg/kg.
Carcinogenicity:
Dimethyl sulfate - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2A carcinogen Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: DIMETHYL SULPHATE
Hazard Class: 6.1 (8)
UN Number: 1595
Packing Group:
IMO
Shipping Name: DIMETHYL SULPHATE
Hazard Class: 6.1
UN Number: 1595
Packing Group: I
RID/ADR
Shipping Name: DIMETHYL SULPHATE
Hazard Class: 6.1
UN Number: 1595
Packing group: I
USA RQ: CAS# 77-78-1: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ C
Risk Phrases:
R 45 May cause cancer.
R 25 Toxic if swallowed.
R 26 Very toxic by inhalation.
R 34 Causes burns.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 77-78-1: 2
Canada
CAS# 77-78-1 is listed on Canadas DSL List.
CAS# 77-78-1 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 77-78-1 is listed on the TSCA inventory.
