Name:
Doyle dirhodium catalyst - RH2(5S-MEPY)4
Synonym:
Dirhodium(II)tetrakis[methyl 2-pyrrolidone-5 (S)-carboxylate], acetonitrile comple
CAS:
67-63-0
Section 1 - Chemical Product
MSDS Name:Doyle dirhodium catalyst - RH2(5S-MEPY)4
Synonym:Dirhodium(II)tetrakis[methyl 2-pyrrolidone-5 (S)-carboxylate], acetonitrile comple
Synonym:Dirhodium(II)tetrakis[methyl 2-pyrrolidone-5 (S)-carboxylate], acetonitrile comple
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-63-0 | 2-Propanol | 200-661-7 |
| Hazard Symbols: XN Risk Phrases: 20/21/22 41 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Risk of serious damage to eyes.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes severe eye irritation and possible injury.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Exposure produces central nervous system depression.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Prolonged exposure may produce a narcotic effect.
Prolonged or repeated exposure may cause nausea, dizziness, and headache.
Harmful by inhalation, in contact with skin and if swallowed. Risk of serious damage to eyes.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes severe eye irritation and possible injury.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Exposure produces central nervous system depression.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Prolonged exposure may produce a narcotic effect.
Prolonged or repeated exposure may cause nausea, dizziness, and headache.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May form explosive peroxides. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May form explosive peroxides. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Remove all sources of ignition. Provide ventilation.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Remove all sources of ignition. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Do not get on skin or in eyes. Avoid ingestion and inhalation.
Keep from contact with moist air and steam.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Do not get on skin or in eyes. Avoid ingestion and inhalation.
Keep from contact with moist air and steam.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 67-63-0: United Kingdom, WEL - TWA: 400 ppm TWA; 999 mg/m3 TWA United Kingdom, WEL - STEL: 500 ppm STEL; 1250 mg/m3 STEL United States OSHA: 400 ppm TWA; 980 mg/m3 TWA Belgium - TWA: 400 ppm VLE; 997 mg/m3 VLE Belgium - STEL: 500 ppm VLE; 1248 mg/m3 VLE France - VLE: 400 ppm VLE; 980 mg/m3 VLE Germany: 200 ppm TWA; 500 mg/m3 TWA Japan: 400 ppm Ceiling; 980 mg/m3 Ceiling Malaysia: 400 ppm TWA; 983 mg/m3 TWA Netherlands: 250 ppm MAC; 650 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 400 ppm VLA-ED; 998 mg/m3 VLA-ED Spain: 500 ppm VLA-EC; 1250 mg/m3 VLA-EC CAS# 75-05-8: United Kingdom, WEL - TWA: 40 ppm TWA; 68 mg/m3 TWA United Kingdom, WEL - STEL: 60 ppm STEL; 102 mg/m3 STEL United States OSHA: 40 ppm TWA; 70 mg/m3 TWA Belgium - TWA: 40 ppm VLE; 68 mg/m3 VLE Belgium - STEL: 60 ppm VLE; 102 mg/m3 VLE France - VME: 40 ppm VME; 70 mg/m3 VME Germany: 20 ppm TWA; 34 mg/m3 TWA Germany: Skin absorber Malaysia: 40 ppm TWA; 67 mg/m3 TWA Netherlands: 40 ppm MAC; 70 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 40 ppm VLA-ED; 68 mg/m3 VLA-ED Spain: 60 ppm VLA-EC; 102 mg/m3 VLA-EC CAS# 132435-65-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 67-63-0: United Kingdom, WEL - TWA: 400 ppm TWA; 999 mg/m3 TWA United Kingdom, WEL - STEL: 500 ppm STEL; 1250 mg/m3 STEL United States OSHA: 400 ppm TWA; 980 mg/m3 TWA Belgium - TWA: 400 ppm VLE; 997 mg/m3 VLE Belgium - STEL: 500 ppm VLE; 1248 mg/m3 VLE France - VLE: 400 ppm VLE; 980 mg/m3 VLE Germany: 200 ppm TWA; 500 mg/m3 TWA Japan: 400 ppm Ceiling; 980 mg/m3 Ceiling Malaysia: 400 ppm TWA; 983 mg/m3 TWA Netherlands: 250 ppm MAC; 650 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 400 ppm VLA-ED; 998 mg/m3 VLA-ED Spain: 500 ppm VLA-EC; 1250 mg/m3 VLA-EC CAS# 75-05-8: United Kingdom, WEL - TWA: 40 ppm TWA; 68 mg/m3 TWA United Kingdom, WEL - STEL: 60 ppm STEL; 102 mg/m3 STEL United States OSHA: 40 ppm TWA; 70 mg/m3 TWA Belgium - TWA: 40 ppm VLE; 68 mg/m3 VLE Belgium - STEL: 60 ppm VLE; 102 mg/m3 VLE France - VME: 40 ppm VME; 70 mg/m3 VME Germany: 20 ppm TWA; 34 mg/m3 TWA Germany: Skin absorber Malaysia: 40 ppm TWA; 67 mg/m3 TWA Netherlands: 40 ppm MAC; 70 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 40 ppm VLA-ED; 68 mg/m3 VLA-ED Spain: 60 ppm VLA-EC; 102 mg/m3 VLA-EC CAS# 132435-65-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 258 deg C dec
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density:
Molecular Formula: C24H32N4O12Rh2.(C2H3N)n.(C3H8O)n
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. This material may be sensitive to peroxide formation.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Isopropanol is susceptible to autoxidation and therefore should be classified as peroxidizable., strong reducing agents, strong oxidizing agents, acids, acid anhydrides, bases, sulfur, alkali metals, perchlorates, indium, dinitrogen tetraoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures. This material may be sensitive to peroxide formation.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Isopropanol is susceptible to autoxidation and therefore should be classified as peroxidizable., strong reducing agents, strong oxidizing agents, acids, acid anhydrides, bases, sulfur, alkali metals, perchlorates, indium, dinitrogen tetraoxide.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-63-0: NT8050000 CAS# 75-05-8: AL7700000 CAS# 132435-65-5 unlisted.
LD50/LC50:
CAS# 67-63-0: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 500 mg Mild; Inhalation, mouse: LC50 = 53000 mg/m3; Inhalation, rat: LC50 = 16000 ppm/8H; Inhalation, rat: LC50 = 72600 mg/m3; Oral, mouse: LD50 = 3600 mg/kg; Oral, mouse: LD50 = 3600 mg/kg; Oral, rabbit: LD50 = 6410 mg/kg; Oral, rat: LD50 = 5045 mg/kg; Oral, rat: LD50 = 5000 mg/kg; Skin, rabbit: LD50 = 12800 mg/kg.
CAS# 75-05-8: Draize test, rabbit, eye: 100 uL/24H Moderate; Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 = 2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 = 269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460 mg/kg; Skin, rabbit: LD50 = >2 gm/kg.
CAS# 132435-65-5.
Carcinogenicity:
2-Propanol - Not listed by ACGIH, IARC, or NTP.
Acetonitrile - Not listed by ACGIH, IARC, or NTP.
Doyle dirhodium catalyst - RH2(5S-MEPY)4 - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 67-63-0: NT8050000 CAS# 75-05-8: AL7700000 CAS# 132435-65-5 unlisted.
LD50/LC50:
CAS# 67-63-0: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 500 mg Mild; Inhalation, mouse: LC50 = 53000 mg/m3; Inhalation, rat: LC50 = 16000 ppm/8H; Inhalation, rat: LC50 = 72600 mg/m3; Oral, mouse: LD50 = 3600 mg/kg; Oral, mouse: LD50 = 3600 mg/kg; Oral, rabbit: LD50 = 6410 mg/kg; Oral, rat: LD50 = 5045 mg/kg; Oral, rat: LD50 = 5000 mg/kg; Skin, rabbit: LD50 = 12800 mg/kg.
CAS# 75-05-8: Draize test, rabbit, eye: 100 uL/24H Moderate; Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 = 2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 = 269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460 mg/kg; Skin, rabbit: LD50 = >2 gm/kg.
CAS# 132435-65-5.
Carcinogenicity:
2-Propanol - Not listed by ACGIH, IARC, or NTP.
Acetonitrile - Not listed by ACGIH, IARC, or NTP.
Doyle dirhodium catalyst - RH2(5S-MEPY)4 - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
CAS#: 67-63-0: LC50 Pimephales promelas (fathead minnows) 11,830 mg/l/1 hr (static bioassay in Lake Superior water at 18-22 deg C).; LC50 Pimephales promelas (fathead minnows) 9.64 g/l/96 hr (95% confidence limit 9.23-10.0 g/l); age 31 days old, water hardness 48.3 mg/l (CaCO3), temp 24.4 deg C, pH 7.79, dissolved oxygen 6.6 mg/l, alkalinity 45.9 mg/l (CaCO3), tank vol: 6.3 l, additions: 3.75 vol/day (flow-through bioassay).; Cell multiplication test Scenedesmus guadricauda (green algae) 1800 mg/l.
CAS#: 67-63-0: LC50 Pimephales promelas (fathead minnows) 11,830 mg/l/1 hr (static bioassay in Lake Superior water at 18-22 deg C).; LC50 Pimephales promelas (fathead minnows) 9.64 g/l/96 hr (95% confidence limit 9.23-10.0 g/l); age 31 days old, water hardness 48.3 mg/l (CaCO3), temp 24.4 deg C, pH 7.79, dissolved oxygen 6.6 mg/l, alkalinity 45.9 mg/l (CaCO3), tank vol: 6.3 l, additions: 3.75 vol/day (flow-through bioassay).; Cell multiplication test Scenedesmus guadricauda (green algae) 1800 mg/l.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 75-05-8: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 41 Risk of serious damage to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 67-63-0: 1
CAS# 75-05-8: 2
CAS# 132435-65-5: No information available.
Canada
CAS# 67-63-0 is listed on Canadas DSL List.
CAS# 75-05-8 is listed on Canadas DSL List.
CAS# 67-63-0 is listed on Canadas Ingredient Disclosure List.
CAS# 75-05-8 is listed on Canadas Ingredient Disclosure List.
CAS# 132435-65-5 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-63-0 is listed on the TSCA inventory.
CAS# 75-05-8 is listed on the TSCA inventory.
CAS# 132435-65-5 is not listed on the TSCA inventory.
It is for research and development use only.
