Name:
epsilon-Caprolactam
Synonym:
2-Oxohexamethyleneimine; 6-Aminocaproic acid lactam; 6-Aminohexanoic acid cyclic lactam; 1-Aza-2-cycloheptanone; Hexahydro-2H-azepin-2-one; Aminocaproic lactam; Caprolactam
CAS:
105-60-2
Section 1 - Chemical Product
MSDS Name:epsilon-Caprolactam
Synonym:2-Oxohexamethyleneimine; 6-Aminocaproic acid lactam; 6-Aminohexanoic acid cyclic lactam; 1-Aza-2-cycloheptanone; Hexahydro-2H-azepin-2-one; Aminocaproic lactam; Caprolactam
Synonym:2-Oxohexamethyleneimine; 6-Aminocaproic acid lactam; 6-Aminohexanoic acid cyclic lactam; 1-Aza-2-cycloheptanone; Hexahydro-2H-azepin-2-one; Aminocaproic lactam; Caprolactam
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 105-60-2 | epsilon-Caprolactam | >99 | 203-313-2 |
| Hazard Symbols: XN Risk Phrases: 20/22 36/37/38 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation and if swallowed. Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation. Vapors cause eye irritation.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May cause dermatitis. May be harmful if absorbed through the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause lung damage. May cause central nervous system effects such as nausea and headache.
Material has a very low vapor pressure and inhalation exposures are not expected unless material is heated or misted.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Animal studies indicate that the product may affect the liver and kidneys.
Harmful by inhalation and if swallowed. Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye irritation. Vapors cause eye irritation.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May cause dermatitis. May be harmful if absorbed through the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause lung damage. May cause central nervous system effects such as nausea and headache.
Material has a very low vapor pressure and inhalation exposures are not expected unless material is heated or misted.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Animal studies indicate that the product may affect the liver and kidneys.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing vapors from heated material. Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Avoid breathing spray or mist.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Store protected from moisture. Separate from oxidizing materials.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing vapors from heated material. Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Avoid breathing spray or mist.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Store protected from moisture. Separate from oxidizing materials.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 105-60-2: United Kingdom, WEL - TWA: 1 mg/m3 TWA (dust); 10 mg/m3 TWA (dust vapour) United Kingdom, WEL - STEL: 3 mg/m3 STEL (dust); 20 mg/m3 STEL (d and vapour) Belgium - TWA: 2 ppm VLE (vapor); 1 mg/m3 VLE (dust); 10 mg/m3 VL (vapor) Belgium - STEL: 8.7 ppm VLE (vapor); 3 mg/m3 VLE (dust); 40 mg/m3 (vapor) France - VME: 5 ppm VME (vapor); 20 mg/m3 VME (vapor); 1 mg/m3 VM (dust) Germany: 5 mg/m3 TWA (steam and dust, inhalable fraction) Malaysia: 5 ppm TWA (vapor); 1 mg/m3 TWA (particulate); 23 mg/m3 (vapor) Netherlands: 5 ppm MAC (fume); 20 mg/m3 MAC (fume); 1 mg/m3 MAC (dust) Russia: 10 mg/m3 TWA (dust) Spain: 10 mg/m3 VLA-ED (dust and vapor) Spain: 40 mg/m3 VLA-EC (dust and vapor) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 105-60-2: United Kingdom, WEL - TWA: 1 mg/m3 TWA (dust); 10 mg/m3 TWA (dust vapour) United Kingdom, WEL - STEL: 3 mg/m3 STEL (dust); 20 mg/m3 STEL (d and vapour) Belgium - TWA: 2 ppm VLE (vapor); 1 mg/m3 VLE (dust); 10 mg/m3 VL (vapor) Belgium - STEL: 8.7 ppm VLE (vapor); 3 mg/m3 VLE (dust); 40 mg/m3 (vapor) France - VME: 5 ppm VME (vapor); 20 mg/m3 VME (vapor); 1 mg/m3 VM (dust) Germany: 5 mg/m3 TWA (steam and dust, inhalable fraction) Malaysia: 5 ppm TWA (vapor); 1 mg/m3 TWA (particulate); 23 mg/m3 (vapor) Netherlands: 5 ppm MAC (fume); 20 mg/m3 MAC (fume); 1 mg/m3 MAC (dust) Russia: 10 mg/m3 TWA (dust) Spain: 10 mg/m3 VLA-ED (dust and vapor) Spain: 40 mg/m3 VLA-EC (dust and vapor) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Crystals
Color: white
Odor: unpleasant odor
pH: Not available.
Vapor Pressure: 0.0016 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 268 deg C @ 760 mm Hg
Freezing/Melting Point: 68-71 deg C
Autoignition Temperature: 374 deg C ( 705.20 deg F)
Flash Point: 125 deg C ( 257.00 deg F)
Explosion Limits, lower: 1.40 vol %
Explosion Limits, upper: 8.00 vol %
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.02 @ 75C
Molecular Formula: C6H11NO
Molecular Weight: 113.16
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Polymerization of caprolactam is slow and not violent. It does not occur at < 100C (212F).
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Stable under normal temperatures and pressures. Polymerization of caprolactam is slow and not violent. It does not occur at < 100C (212F).
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 105-60-2: CM3675000 LD50/LC50:
CAS# 105-60-2: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 450 mg/m3; Inhalation, rat: LC50 = 300 mg/m3/2H; Oral, mouse: LD50 = 930 mg/kg; Oral, rat: LD50 = 1210 mg/kg; Skin, rabbit: LD50 = 1410 uL/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
epsilon-Caprolactam - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 105-60-2: CM3675000 LD50/LC50:
CAS# 105-60-2: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 450 mg/m3; Inhalation, rat: LC50 = 300 mg/m3/2H; Oral, mouse: LD50 = 930 mg/kg; Oral, rat: LD50 = 1210 mg/kg; Skin, rabbit: LD50 = 1410 uL/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
epsilon-Caprolactam - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/22 Harmful by inhalation and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 105-60-2: 1
Canada
CAS# 105-60-2 is listed on Canadas DSL List.
CAS# 105-60-2 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 105-60-2 is listed on the TSCA inventory.
