Name:
Ethylmercurithiosalicylic acid sodium salt
Synonym:
Thimerosal; Merthiolate sodium; Ethyl(2-mercaptobenzoato-S)mercury sodium salt; Sodium ethylmercurithiosalicylate
CAS:
54-64-8
Section 1 - Chemical Product
MSDS Name:Ethylmercurithiosalicylic acid sodium salt
Synonym:Thimerosal; Merthiolate sodium; Ethyl(2-mercaptobenzoato-S)mercury sodium salt; Sodium ethylmercurithiosalicylate
Synonym:Thimerosal; Merthiolate sodium; Ethyl(2-mercaptobenzoato-S)mercury sodium salt; Sodium ethylmercurithiosalicylate
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 54-64-8 | Ethylmercurithiosalicylic acid, sodium | >97 | 200-210-4 |
| Hazard Symbols: T+ N Risk Phrases: 26/27/28 33 50/53 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Light sensitive.Toxic.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May cause erythema (redness) and edema (fluid buildup) with crusting and scaling.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. Mercaptans may cause nausea and headache. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), cold extremities and rapid pulse. May cause central nervous system effects and/or neurological effects. Human fatalities have been reported from acute poisoning.
Inhalation:
Causes respiratory tract irritation. May cause kidney damage. May cause allergic respiratory tract irritation. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), cold extremities and rapid pulse. Mercaptans may cause nausea and headache. Can produce delayed pulmonary edema.
Acute exposure to high concentrations of mercury vapors may cause severe respiratory tract irritation. May cause central, peripheral, and autonomic nervous system effects.
Chronic:
Effects may be delayed. Chronic exposure to mercury may cause permanent central nervous system damage, fatigue, weight loss, tremors, personality changes. Chronic ingestion may cause accumulation of mercury in body tissues. Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes. Adverse reproductive effects have been reported in animals. Chronic exposure to mercury vapors may produce weakness, fatigue, anorexia, loss of weight and gastrointestinal disturbances which is collectively referred to as asthenic-vegetative syndrome or micromercurialism.
Chronic exposure to mercury compounds may produce immunologic glomerular disease.
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Light sensitive.Toxic.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May cause erythema (redness) and edema (fluid buildup) with crusting and scaling.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. Mercaptans may cause nausea and headache. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), cold extremities and rapid pulse. May cause central nervous system effects and/or neurological effects. Human fatalities have been reported from acute poisoning.
Inhalation:
Causes respiratory tract irritation. May cause kidney damage. May cause allergic respiratory tract irritation. Exposure to high concentrations of mercaptans can produce unconsciousness with cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), cold extremities and rapid pulse. Mercaptans may cause nausea and headache. Can produce delayed pulmonary edema.
Acute exposure to high concentrations of mercury vapors may cause severe respiratory tract irritation. May cause central, peripheral, and autonomic nervous system effects.
Chronic:
Effects may be delayed. Chronic exposure to mercury may cause permanent central nervous system damage, fatigue, weight loss, tremors, personality changes. Chronic ingestion may cause accumulation of mercury in body tissues. Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes. Adverse reproductive effects have been reported in animals. Chronic exposure to mercury vapors may produce weakness, fatigue, anorexia, loss of weight and gastrointestinal disturbances which is collectively referred to as asthenic-vegetative syndrome or micromercurialism.
Chronic exposure to mercury compounds may produce immunologic glomerular disease.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively. The concentration of mercury in whole blood is a reasonable measure of the body-burden of mercury and thus is used for monitoring purposes.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively. The concentration of mercury in whole blood is a reasonable measure of the body-burden of mercury and thus is used for monitoring purposes.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes.
Extinguishing Media:
Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes.
Extinguishing Media:
Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Store protected from moisture. Store protected from light. Store with desiccant.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from metals. Store protected from moisture. Store protected from light. Store with desiccant.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 54-64-8: United States OSHA: 0.1 mg/m3 Ceiling (listed under Mercury, ary and inorganic compounds).
Belgium - TWA: (listed as mercury, aryl and inorganic compounds): mg/m3 VLE (as Hg) France - VME: (listed as mercury, aryl and inorganic compounds): mg/m3 VME (as Hg) Germany: (listed as mercury, aryl and inorganic compounds): 0.1 m VME (as Hg) Malaysia: (listed as mercury, aryl and inorganic compounds): 0.1 mg/m3 TWA (as Hg) Spain: (listed as mercury, aryl and inorganic compounds): 0.1 mg/ VLA-ED (as Hg) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 54-64-8: United States OSHA: 0.1 mg/m3 Ceiling (listed under Mercury, ary and inorganic compounds).
Belgium - TWA: (listed as mercury, aryl and inorganic compounds): mg/m3 VLE (as Hg) France - VME: (listed as mercury, aryl and inorganic compounds): mg/m3 VME (as Hg) Germany: (listed as mercury, aryl and inorganic compounds): 0.1 m VME (as Hg) Malaysia: (listed as mercury, aryl and inorganic compounds): 0.1 mg/m3 TWA (as Hg) Spain: (listed as mercury, aryl and inorganic compounds): 0.1 mg/ VLA-ED (as Hg) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Crystalline powder
Color: white to light cream
Odor: characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 232-233C
Autoignition Temperature: Not applicable.
Flash Point: > 250 deg C (> 482.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 233 deg C
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: C9H9HgNaO2S
Molecular Weight: 404.82
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Light, dust generation, excess heat, moist air.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen sulfide, mercury/mercury oxides, sodium oxide.
Hazardous Polymerization: Has not been reported.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Light, dust generation, excess heat, moist air.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen sulfide, mercury/mercury oxides, sodium oxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 54-64-8: OV8400000 LD50/LC50:
CAS# 54-64-8: Draize test, rabbit, eye: 8 ug Mild; Oral, mouse: LD50 = 91 mg/kg; Oral, rat: LD50 = 75 mg/kg.
Carcinogenicity:
Ethylmercurithiosalicylic acid, sodium salt - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 54-64-8: OV8400000 LD50/LC50:
CAS# 54-64-8: Draize test, rabbit, eye: 8 ug Mild; Oral, mouse: LD50 = 91 mg/kg; Oral, rat: LD50 = 75 mg/kg.
Carcinogenicity:
Ethylmercurithiosalicylic acid, sodium salt - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 13 Keep away from food, drink and animal feeding
stuffs.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36 Wear suitable protective clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 54-64-8: 3
Canada
CAS# 54-64-8 is listed on Canadas DSL List.
CAS# 54-64-8 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 54-64-8 is listed on the TSCA inventory.
