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Name:
Folin and Ciocalteus Phenol Reagent
Synonym:
Non
CAS:
7647-01-0
Section 1 - Chemical Product
MSDS Name:Folin and Ciocalteus Phenol Reagent
Synonym:Non
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name emsds EINECS#
7647-01-0 Hydrochloric acid 3.6 231-595-7
Hazard Symbols: XI
Risk Phrases: 36/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes and skin.Corrosive.
Potential Health Effects
Eye:
May cause irreversible eye injury. Causes severe eye irritation and burns.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration.
Ingestion:
May cause corrosion and permanent tissue destruction of the esophagus and digestive tract. Large doses of lithium may cause dizziness, prostration, and kidney damage. Dehydration, weight loss, slurred speech, blurred vision, sensory loss, ataxia (failure of muscular coordination), tremors, and convulsions may occur.
Inhalation:
Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause erosion of teeth.
Laboratory experiments have resulted in mutagenic effects. Human systemic effects may include coma.

Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes). SPEEDY ACTION IS CRITICAL! Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use extinguishing media most appropriate for the surrounding fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid breathing dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use caution when opening.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.)
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 7647-01-0: United Kingdom, WEL - TWA: 1 ppm TWA (aerosol mist and gas); 2 mg TWA (aerosol mist and gas) United Kingdom, WEL - STEL: 5 ppm STEL (aerosol mist and gas); 8 mg/m3 STEL (aerosol mist and gas) United States OSHA: ; 5 ppm Ceiling; 7 mg/m3 Ceiling Belgium - TWA: 5 ppm VLE; 8 mg/m3 VLE Belgium - STEL: 10 ppm VLE; 15 mg/m3 VLE France - VLE: 5 ppm VLE; 7.5 mg/m3 VLE Germany: 8 mg/m3 TWA Japan: 5 ppm Ceiling; 7.5 mg/m3 Ceiling Malaysia: 5 ppm Ceiling; 7.5 mg/m3 Ceiling Netherlands: 10 ppm STEL; 15 mg/m3 STEL Netherlands: 5 ppm MAC; 8 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 7.6 mg/m3 VLA-ED Spain: 10 ppm VLA-EC; 15 mg/m3 VLA-EC CAS# 7664-38-2: United Kingdom, WEL - TWA: 1 mg/m3 TWA United Kingdom, WEL - STEL: 2 mg/m3 STEL United States OSHA: 1 mg/m3 TWA Belgium - TWA: 1 mg/m3 VLE Belgium - STEL: 2 mg/m3 VLE France - VME: 1 mg/m3 VME France - VLE: 3 mg/m3 VLE Germany: 1 mg/m3 TWA Japan: 1 mg/m3 OEL Malaysia: 1 mg/m3 TWA Netherlands: 0.5 ppm STEL; 2 mg/m3 STEL Netherlands: 0.2 ppm MAC; 1 mg/m3 MAC Spain: 1 mg/m3 VLA-ED Spain: 2 mg/m3 VLA-EC CAS# 7732-18-5: CAS# 10102-40-6: United Kingdom, WEL - TWA: (listed as molybdenum soluble compound 5 mg/m3 TWA (as Mo) United Kingdom, WEL - STEL: (listed as molybdenum soluble compoun 10 mg/m3 STEL (as Mo) United States OSHA: 5 mg/m3 TWA (as Mo) (listed under Molybdenum soluble compounds).
Belgium - TWA: (listed as molybdenum soluble compounds): 5 mg/m3 (as Mo) France - VME: (listed as molybdenum soluble compounds): 5 mg/m3 V (as Mo) France - VLE: (listed as molybdenum soluble compounds): 10 mg/m3 (as Mo) Germany: (listed as molybdenum soluble compounds): 5 mg/m3 VME (a Mo) Malaysia: (listed as molybdenum soluble compounds): 5 mg/m3 TWA ( Mo) Netherlands: (listed as molybdenum soluble compounds): 5 mg/m3 MA (as Mo) Russia: (listed as molybdenum soluble compounds): 2 mg/m3 TWA (as Spain: (listed as molybdenum soluble compounds): 5 mg/m3 VLA-ED ( Mo) CAS# 10213-10-2: United Kingdom, WEL - TWA: (listed as tungsten, soluble compounds mg/m3 TWA (as W) United Kingdom, WEL - STEL: (listed as tungsten, soluble compound 3 mg/m3 STEL (as W) Belgium - TWA: (listed as tungsten, soluble compounds): 1 mg/m3 V (as W) Belgium - STEL: (listed as tungsten, soluble compounds): 3 mg/m3 (as W) Malaysia: (listed as tungsten, soluble compounds): 1 mg/m3 TWA (a Netherlands: (listed as tungsten, soluble compounds): 1 mg/m3 MAC W) Russia: (listed as tungsten): 6 mg/m3 TWA Spain: (listed as tungsten, soluble compounds): 1 mg/m3 VLA-ED (a Spain: (listed as tungsten, soluble compounds): 3 mg/m3 VLA-EC (a CAS# 10373-78-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble in water
Specific Gravity/Density: Not available.
Molecular Formula: mixture
Molecular Weight:

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, contact with water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, amines, alkali, metals, copper, copper alloys, aluminum. Acetate, acetic anhydride, alcohols + hydrogen cyanide, 2-aminoethanol, ammonium hydroxide, calcium carbide, calcium phosphide, cesium acetylene carbide, cesium carbide, chlorosulfonic acid, 1,1-diluorethylene, ethylene diamine, ethyleneimine, fluorine, lithium silicide, magnesium boride, mercuric sulfate, oleum, perchloric acid, potassium permanganate, b-propiolactone, propylene, oxide, rubidium acetylene carbide, rubidium carbide, silver perchlorate + carbotetrachloride, sodium, sodium hydroxide, sulfuric acid, uranium phosphate, vinyl acetate.
Substance polymerizes on contact with aldehydes or epoxides.
Hazardous Decomposition Products:
Hydrogen chloride, oxides of phosphorus, toxic fumes of sodium oxide, hydrogen gas.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7647-01-0: MW4025000 MW4031000 CAS# 7664-38-2: TB6300000 CAS# 7732-18-5: ZC0110000 CAS# 10102-40-6: QA5085000 CAS# 10213-10-2: YO7900000 CAS# 10373-78-1 unlisted.
LD50/LC50:
CAS# 7647-01-0: Inhalation, mouse: LC50 = 1108 ppm/1H; Inhalation, mouse: LC50 = 20487 mg/m3/5M; Inhalation, mouse: LC50 = 3940 mg/m3/30M; Inhalation, mouse: LC50 = 8300 mg/m3/30M; Inhalation, rat: LC50 = 3124 ppm/1H; Inhalation, rat: LC50 = 60938 mg/m3/5M; Inhalation, rat: LC50 = 7004 mg/m3/30M; Inhalation, rat: LC50 = 45000 mg/m3/5M; Inhalation, rat: LC50 = 8300 mg/m3/30M; Oral, rabbit: LD50 = 900 mg/kg.
CAS# 7664-38-2: Draize test, rabbit, eye: 119 mg Severe; Draize test, rabbit, skin: 595 mg/24H Severe; Inhalation, mouse: LC50 = 25.5 mg/m3; Inhalation, rat: LC50 = >850 mg/m3/1H; Inhalation, rat: LC50 = 25.5 mg/m3; Oral, mouse: LD50 = 1.25 gm/kg; Oral, rat: LD50 = 1530 mg/kg; Oral, rat: LD50 = 1.25 gm/kg; Skin, rabbit: LD50 = 2740 mg/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 10102-40-6.
CAS# 10213-10-2.
CAS# 10373-78-1.
CAS# 7664-38-2: Oral, man: TDLo = 1286 uL/kg.; Unreported, man: LDLo = 220 mg/kg. CAS# 7647-01-0: Inhalation, human: LCLo = 1300 ppm/30M.
CAS# 10377-48-7: Oral, woman, TDLo = 6 Carcinogenicity:
Hydrochloric acid - Not listed by ACGIH, IARC, or NTP.
Orthophosphoric acid - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Sodium molybdate - Not listed by ACGIH, IARC, or NTP.
Sodium tungstate - Not listed by ACGIH, IARC, or NTP.
dl-Camphoroquinone, 99% - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Trout LC100=10 mg/l/24H Shrimp LC50=100-330 ppm Starfish LC50=100-330 mg/l/48H Shore crab LC50=240 mg/l/48H Chronic plant toxicity=100 ppm Fish-toxicity LC50:862 mg/l
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 7647-01-0: 5000 lb final RQ; 2270 kg final RQ
USA RQ: CAS# 7664-38-2: 5000 lb final RQ; 2270 kg final RQ

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28 After contact with skin, wash immediately
with...
WGK (Water Danger/Protection)
CAS# 7647-01-0: 1
CAS# 7664-38-2: 1
CAS# 7732-18-5: No information available.
CAS# 10102-40-6: 1
CAS# 10213-10-2: No information available.
CAS# 10373-78-1: No information available.
Canada
CAS# 7647-01-0 is listed on Canadas DSL List.
CAS# 7664-38-2 is listed on Canadas DSL List.
CAS# 7732-18-5 is listed on Canadas DSL List.
CAS# 10373-78-1 is listed on Canadas DSL List.
CAS# 7647-01-0 is listed on Canadas Ingredient Disclosure List.
CAS# 7664-38-2 is listed on Canadas Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 10102-40-6 is not listed on Canadas Ingredient Disclosure List.
CAS# 10213-10-2 is not listed on Canadas Ingredient Disclosure List.
CAS# 10373-78-1 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7647-01-0 is listed on the TSCA inventory.
CAS# 7664-38-2 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 10102-40-6 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).
CAS# 10213-10-2 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).
CAS# 10373-78-1 is listed on the TSCA inventory.