Name:
HBTU 0.1M in (HOBT 0.45M in DMF) 1:1 3-bottle kit peptide synthesis
Synonym:
CAS:
68-12-2
Section 1 - Chemical Product
MSDS Name:HBTU 0.1M in (HOBT 0.45M in DMF) 1:1 3-bottle kit peptide synthesis
Synonym:
Synonym:
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 68-12-2 | Dimethylformamide | 200-679-5 |
| Hazard Symbols: T F Risk Phrases: 11 20/21 36 61 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation and in contact with skin.
Irritating to eyes. May cause harm to the unborn child.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Possible risk of harm to the unborn child.
Highly flammable. Harmful by inhalation and in contact with skin.
Irritating to eyes. May cause harm to the unborn child.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Possible risk of harm to the unborn child.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.
Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Flammables-area.
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 68-12-2: United Kingdom, WEL - TWA: 10 ppm TWA; 30 mg/m3 TWA United Kingdom, WEL - STEL: 20 ppm STEL; 61 mg/m3 STEL United States OSHA: 10 ppm TWA; 30 mg/m3 TWA Belgium - TWA: 10 ppm VLE; 30 mg/m3 VLE France - VME: 10 ppm VME; 30 mg/m3 VME Germany: 10 ppm TWA; 30 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 30 mg/m3 OEL Malaysia: 10 ppm TWA; 30 mg/m3 TWA Netherlands: 5 ppm MAC; 15 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 10 ppm VLA-ED; 30 mg/m3 VLA-ED CAS# 2592-95-2: CAS# 94790-37-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 68-12-2: United Kingdom, WEL - TWA: 10 ppm TWA; 30 mg/m3 TWA United Kingdom, WEL - STEL: 20 ppm STEL; 61 mg/m3 STEL United States OSHA: 10 ppm TWA; 30 mg/m3 TWA Belgium - TWA: 10 ppm VLE; 30 mg/m3 VLE France - VME: 10 ppm VME; 30 mg/m3 VME Germany: 10 ppm TWA; 30 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 30 mg/m3 OEL Malaysia: 10 ppm TWA; 30 mg/m3 TWA Netherlands: 5 ppm MAC; 15 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 10 ppm VLA-ED; 30 mg/m3 VLA-ED CAS# 2592-95-2: CAS# 94790-37-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Not available.
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 68-12-2: LQ2100000 CAS# 2592-95-2: DM1288000 CAS# 94790-37-1 unlisted.
LD50/LC50:
CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Inhalation, rat: LC50 = 3421 ppm/1H; Inhalation, rat: LC50 = 3421 ppm/3H; Inhalation, rat: LC50 = 1948 ppm/4H; Oral, mouse: LD50 = 2900 mg/kg; Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = 4720 mg/kg; Skin, rat: LD50 = >3.2 gm/kg.
CAS# 2592-95-2: Draize test, rabbit, eye: 100 mg Mild.
CAS# 94790-37-1.
Carcinogenicity:
Dimethylformamide - Not listed by ACGIH, IARC, or NTP.
1-Hydroxybenzotriazole - Not listed by ACGIH, IARC, or NTP.
o-Benzotriazol-1-yl-tetramethyluronium hexafluorophosphate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 68-12-2: LQ2100000 CAS# 2592-95-2: DM1288000 CAS# 94790-37-1 unlisted.
LD50/LC50:
CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Inhalation, rat: LC50 = 3421 ppm/1H; Inhalation, rat: LC50 = 3421 ppm/3H; Inhalation, rat: LC50 = 1948 ppm/4H; Oral, mouse: LD50 = 2900 mg/kg; Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = 4720 mg/kg; Skin, rat: LD50 = >3.2 gm/kg.
CAS# 2592-95-2: Draize test, rabbit, eye: 100 mg Mild.
CAS# 94790-37-1.
Carcinogenicity:
Dimethylformamide - Not listed by ACGIH, IARC, or NTP.
1-Hydroxybenzotriazole - Not listed by ACGIH, IARC, or NTP.
o-Benzotriazol-1-yl-tetramethyluronium hexafluorophosphate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
IMO
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
RID/ADR
No information available.
USA RQ: CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 61 May cause harm to the unborn child.
R 11 Highly flammable.
R 20/21 Harmful by inhalation and in contact with
skin.
R 36 Irritating to eyes.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 16 Keep away from sources of ignition - No
smoking.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 68-12-2: 1
CAS# 2592-95-2: No information available.
CAS# 94790-37-1: No information available.
Canada
CAS# 68-12-2 is listed on Canadas DSL List.
CAS# 2592-95-2 is listed on Canadas DSL List.
CAS# 68-12-2 is listed on Canadas Ingredient Disclosure List.
CAS# 2592-95-2 is not listed on Canadas Ingredient Disclosure List.
CAS# 94790-37-1 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 68-12-2 is listed on the TSCA inventory.
CAS# 2592-95-2 is listed on the TSCA inventory.
CAS# 94790-37-1 is not listed on the TSCA inventory.
It is for research and development use only.
