MSDS Name:Hydrochloric acid 4N solution in 1 4-dioxane
Synonym:None

EMERGENCY OVERVIEW
Highly flammable. May form explosive peroxides. Causes burns.
Irritating to eyes and respiratory system. Limited evidence of a carcinogenic effect. Repeated exposure may cause skin dryness or cracking.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated contact may cause irritation and/or dermatitis. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause perforation of the digestive tract. May cause systemic effects.
Inhalation:
Effects may be delayed. Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Olfactory fatigue may occur.
Chronic:
Repeated exposure may cause erosion of teeth. May cause liver and kidney damage. May cause cancer according to animal studies. Effects may be delayed. Prolonged exposure may cause conjunctivitis, photosensitization, and possible blindness. May cause adverse reproductive effects.

Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Get medical aid immediately. If breathing is difficult, give oxygen.
Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. May form explosive peroxides. May accumulate static electrical charges, and may cause ignition of its own vapors.
Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.

Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use spark-proof tools and explosion proof equipment. Loosen closure cautiously before opening. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. If peroxide formation is suspected, do not open or move container. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources.

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 123-91-1: United Kingdom, WEL - TWA: 25 ppm TWA; 91 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 366 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 25 ppm VLE; 91 mg/m3 VLE France - VME: 10 ppm VME; 35 mg/m3 VME France - VLE: 40 ppm VLE; 140 mg/m3 VLE Germany: 20 ppm TWA; 73 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 36 mg/m3 OEL Malaysia: 20 ppm TWA; 72.1 mg/m3 TWA Netherlands: 22 ppm STEL; 80 mg/m3 STEL Netherlands: 11 ppm MAC; 40 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 20 ppm VLA-ED; 74 mg/m3 VLA-ED CAS# 7647-01-0: United Kingdom, WEL - TWA: 1 ppm TWA (aerosol mist and gas); 2 mg TWA (aerosol mist and gas) United Kingdom, WEL - STEL: 5 ppm STEL (aerosol mist and gas); 8 mg/m3 STEL (aerosol mist and gas) United States OSHA: ; 5 ppm Ceiling; 7 mg/m3 Ceiling Belgium - TWA: 5 ppm VLE; 8 mg/m3 VLE Belgium - STEL: 10 ppm VLE; 15 mg/m3 VLE France - VLE: 5 ppm VLE; 7.5 mg/m3 VLE Germany: 8 mg/m3 TWA Japan: 5 ppm Ceiling; 7.5 mg/m3 Ceiling Malaysia: 5 ppm Ceiling; 7.5 mg/m3 Ceiling Netherlands: 10 ppm STEL; 15 mg/m3 STEL Netherlands: 5 ppm MAC; 8 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 7.6 mg/m3 VLA-ED Spain: 10 ppm VLA-EC; 15 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 12 deg C-20 deg C
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: Solution
Molecular Weight: 0

Chemical Stability:
Prolonged exposure to air and sunlight may form unstable peroxides.
Tends to form explosive peroxides; especially when anhydrous. Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Conditions to Avoid:
Light, ignition sources, excess heat, electrical sparks.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

RTECS#:
CAS# 123-91-1: JG8225000 CAS# 7647-01-0: MW4025000 MW4031000 LD50/LC50:
CAS# 123-91-1: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 100 mg/24H Moderate; Inhalation, mouse: LC50 = 37 gm/m3/2H; Inhalation, rat: LC50 = 46 gm/m3/2H; Oral, mouse: LD50 = 5300 mg/kg; Oral, rabbit: LD50 = 2 gm/kg; Oral, rat: LD50 = 4200 mg/kg; Skin, rabbit: LD50 = 7600 uL/kg.
CAS# 7647-01-0: Inhalation, mouse: LC50 = 1108 ppm/1H; Inhalation, mouse: LC50 = 20487 mg/m3/5M; Inhalation, mouse: LC50 = 3940 mg/m3/30M; Inhalation, mouse: LC50 = 8300 mg/m3/30M; Inhalation, rat: LC50 = 3124 ppm/1H; Inhalation, rat: LC50 = 60938 mg/m3/5M; Inhalation, rat: LC50 = 7004 mg/m3/30M; Inhalation, rat: LC50 = 45000 mg/m3/5M; Inhalation, rat: LC50 = 8300 mg/m3/30M; Oral, rabbit: LD50 = 900 mg/kg.
Carcinogenicity:
1,4-Dioxane - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Hydrogen chloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = >10,000mg/L; 96 Hr.; Static conditions, 23 degrees CWater flea Daphnia: EC50 =163 mg/L; 48 Hr.; Static Condition, 20-21 degrees CFish: Pseudomonas putida:

Dispose of in a manner consistent with federal, state, and local regulations.

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 123-91-1: 100 lb final RQ; 45.4 kg final RQ
USA RQ: CAS# 7647-01-0: 5000 lb final RQ; 2270 kg final RQ

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F C
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 34 Causes burns.
R 36/37 Irritating to eyes and respiratory system.
R 40 Limited evidence of a carcinogenic effect.
R 66 Repeated exposure may cause skin dryness or
cracking.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 123-91-1: 2
CAS# 7647-01-0: 1
Canada
CAS# 123-91-1 is listed on Canadas DSL List.
CAS# 7647-01-0 is listed on Canadas DSL List.
CAS# 123-91-1 is listed on Canadas Ingredient Disclosure List.
CAS# 7647-01-0 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 123-91-1 is listed on the TSCA inventory.
CAS# 7647-01-0 is listed on the TSCA inventory.