Name:
Hygromycin B
Synonym:
CAS:
7732-18-5
Section 1 - Chemical Product
MSDS Name:Hygromycin B
Synonym:
Synonym:
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 7732-18-5 | Water | Balance | 231-791-2 |
| Hazard Symbols: T+ Risk Phrases: 26/27/28 36/37/38 42/43 48 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation and skin contact. Danger of serious damage to health by prolonged exposure.Highly toxic.
Potential Health Effects
Eye:
Lachrymator (substance which increases the flow of tears). May cause painful conjunctivitis, photophobia, tearing, and corneal opacity. Causes eye irritation and possible injury.
Skin:
Causes skin irritation. May be fatal if absorbed through the skin.
May cause an allergic reaction in certain individuals.
Ingestion:
May be fatal if swallowed. May cause liver and kidney damage. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause central nervous system effects.
Hearing loss and deafness have been reported. May cause blood abnormalities.
Inhalation:
May be fatal if inhaled. May cause allergic respiratory reaction.
May cause respiratory tract irritation. May cause hearing impairment. May cause central nervous system effects.
Chronic:
May cause liver and kidney damage.
Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation and skin contact. Danger of serious damage to health by prolonged exposure.Highly toxic.
Potential Health Effects
Eye:
Lachrymator (substance which increases the flow of tears). May cause painful conjunctivitis, photophobia, tearing, and corneal opacity. Causes eye irritation and possible injury.
Skin:
Causes skin irritation. May be fatal if absorbed through the skin.
May cause an allergic reaction in certain individuals.
Ingestion:
May be fatal if swallowed. May cause liver and kidney damage. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause central nervous system effects.
Hearing loss and deafness have been reported. May cause blood abnormalities.
Inhalation:
May be fatal if inhaled. May cause allergic respiratory reaction.
May cause respiratory tract irritation. May cause hearing impairment. May cause central nervous system effects.
Chronic:
May cause liver and kidney damage.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
POISON material. If swallowed, get medical aid immediately. Only induce vomiting if directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
POISON material. If swallowed, get medical aid immediately. Only induce vomiting if directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Evacuate unnecessary personnel. Approach spill from upwind. Keep unnecessary and unprotected personnel away.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Evacuate unnecessary personnel. Approach spill from upwind. Keep unnecessary and unprotected personnel away.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Storage temperatures of 0-5C (32-41F) are recommended.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Storage temperatures of 0-5C (32-41F) are recommended.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7732-18-5: CAS# 31282-04-9: Russia: 0.001 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7732-18-5: CAS# 31282-04-9: Russia: 0.001 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: dark brown
Odor: slight
pH: 9-11
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: Solution
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Stable.
Conditions to Avoid:
Excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7732-18-5: ZC0110000 CAS# 31282-04-9: WK2130000 LD50/LC50:
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 31282-04-9: Dermal, guinea pig: LD50 = 55 mg/kg; Inhalation, rat: LC50 = 2220 ug/m3/4H; Inhalation, rat: LC50 = 2.2 mg/m3; Oral, mouse: LD50 = 46000 units/kg; Oral, mouse: LD50 = 46 mg/kg; Oral, rat: LD50 = 13 mg/kg.
Skin, rabbit: LD50 = 130-250 mg/kg.
Carcinogenicity:
Water - Not listed by ACGIH, IARC, or NTP.
Hygromycin B - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 7732-18-5: ZC0110000 CAS# 31282-04-9: WK2130000 LD50/LC50:
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
CAS# 31282-04-9: Dermal, guinea pig: LD50 = 55 mg/kg; Inhalation, rat: LC50 = 2220 ug/m3/4H; Inhalation, rat: LC50 = 2.2 mg/m3; Oral, mouse: LD50 = 46000 units/kg; Oral, mouse: LD50 = 46 mg/kg; Oral, rat: LD50 = 13 mg/kg.
Skin, rabbit: LD50 = 130-250 mg/kg.
Carcinogenicity:
Water - Not listed by ACGIH, IARC, or NTP.
Hygromycin B - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2810
Packing Group: II
IMO
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2810
Packing Group: II
RID/ADR
Shipping Name: TOXIC LIQUID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2810
Packing group: II
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 42/43 May cause sensitization by inhalation and
skin contact.
R 48 Danger of serious damage to health by prolonged
exposure.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 7732-18-5: No information available.
CAS# 31282-04-9: 2
Canada
CAS# 7732-18-5 is listed on Canadas DSL List.
CAS# 7732-18-5 is not listed on Canadas Ingredient Disclosure List.
CAS# 31282-04-9 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7732-18-5 is listed on the TSCA inventory.
CAS# 31282-04-9 is not listed on the TSCA inventory.
It is for research and development use only.
