Name:
Iso-Phorone
Synonym:
3,5,5-Trimethyl-2-Cyclohexene-1-On
CAS:
78-59-1
Section 1 - Chemical Product
MSDS Name:Iso-Phorone
Synonym:3,5,5-Trimethyl-2-Cyclohexene-1-On
Synonym:3,5,5-Trimethyl-2-Cyclohexene-1-On
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 78-59-1 | Isophorone | 100 | 201-126-0 |
| Hazard Symbols: XN Risk Phrases: 21 36/37/38 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful in contact with skin. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
Exposure may cause irritation and possible burns. May be harmful if absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Dust is irritating to the respiratory tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated exposure may cause adverse reproductive effects.
Harmful in contact with skin. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
Exposure may cause irritation and possible burns. May be harmful if absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Dust is irritating to the respiratory tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated exposure may cause adverse reproductive effects.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Containers may explode when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Containers may explode when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation. Clean up residual material by washing area with a 2-5% solution of soda ash.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation. Clean up residual material by washing area with a 2-5% solution of soda ash.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use only in a well-ventilated area.
Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: colourless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 215 deg C
Freezing/Melting Point: -8 deg C
Autoignition Temperature: Not applicable.
Flash Point: 84 deg C ( 183.20 deg F)
Explosion Limits, lower: 0.8
Explosion Limits, upper: 3.8
Decomposition Temperature: Not available.
Solubility in water: Slightly soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula: C9H14O
Molecular Weight: 138.0974
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 78-59-1: GW7700000 LD50/LC50:
CAS# 78-59-1: Draize test, rabbit, eye: 920 ug Severe; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 100 mg/24H Mild; Inhalation, rat: LC50 = 7 gm/m3; Oral, mouse: LD50 = 2690 mg/kg; Oral, rabbit: LD50 = 1420 mg/kg; Oral, rat: LD50 = 1870 mg/kg; Skin, rabbit: LD50 = 1500 uL/kg; Skin, rat: LD50 = 1390 mg/kg.
Carcinogenicity:
Isophorone - ACGIH: A3 - Animal Carcinogen See actual entry in RTECS for complete information.
CAS# 78-59-1: GW7700000 LD50/LC50:
CAS# 78-59-1: Draize test, rabbit, eye: 920 ug Severe; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 100 mg/24H Mild; Inhalation, rat: LC50 = 7 gm/m3; Oral, mouse: LD50 = 2690 mg/kg; Oral, rabbit: LD50 = 1420 mg/kg; Oral, rat: LD50 = 1870 mg/kg; Skin, rabbit: LD50 = 1500 uL/kg; Skin, rat: LD50 = 1390 mg/kg.
Carcinogenicity:
Isophorone - ACGIH: A3 - Animal Carcinogen See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 21 Harmful in contact with skin.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 78-59-1: 1
United Kingdom Occupational Exposure Limits
CAS# 78-59-1: OES-United Kingdom, STEL 5 ppm STEL; 29 mg/m3 STEL
Canada
CAS# 78-59-1 is listed on Canadas DSL List.
CAS# 78-59-1 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 78-59-1: OEL-AUSTRALIA:TWA 5 ppm (25 mg/m3)
OEL-BELGIUM:STEL 5 ppm (28 mg/m3)
OEL-DENMARK:STEL 5 ppm (25 mg/m3)
OEL-FINLAND:TWA 5 ppm (28 mg/m3);STEL 10 ppm (56 mg/m3)
OEL-FRANCE:STEL 5 ppm (25 mg/m3)
OEL-GERMANY:TWA 5 ppm (28 mg/m3)
OEL-THE NETHERLANDS:TWA 5 ppm (25 mg/m3)
OEL-THE PHILIPPINES:TWA 25 ppm (140 mg/m3)
OEL-POLAND:TWA 5 mg/m3
OEL-RUSSIA:STEL 1 mg/m3
OEL-SWEDEN:STEL 5 ppm (30 mg/m3)
OEL-SWITZERLAND:TWA 5 ppm (28 mg/m3)
OEL-SWITZERLAND:TWA 5 ppm (28 mg/m3) JANUARY 199
OEL-TURKEY:TWA 25 ppm (149 mg/m3)
OEL-UNITED KINGDOM:TWA 5 ppm (25 mg/m3);STEL 5 pp (25 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 78-59-1 is listed on the TSCA inventory.
