Name:
Iso-Propylamine
Synonym:
2-Aminopropane, 2-Propylamine, 2-Propanamine; sec-propylamine
CAS:
75-31-0
Section 1 - Chemical Product
MSDS Name:Iso-Propylamine
Synonym:2-Aminopropane, 2-Propylamine, 2-Propanamine; sec-propylamine
Synonym:2-Aminopropane, 2-Propylamine, 2-Propanamine; sec-propylamine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 75-31-0 | Isopropylamine | ca.100 | 200-860-9 |
| Hazard Symbols: XI F+ Risk Phrases: 12 36/37/38 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Extremely flammable. Irritating to eyes, respiratory system and skin.Corrosive.
Potential Health Effects
Eye:
May cause blue haze or halo vision. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.
Skin:
Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes severe skin irritation and burns.
Ingestion:
Causes gastrointestinal tract burns. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Inhalation of high concentrations may cause narcotic effects. Can produce delayed pulmonary edema. Causes respiratory tract irritation with possible burns.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.
Extremely flammable. Irritating to eyes, respiratory system and skin.Corrosive.
Potential Health Effects
Eye:
May cause blue haze or halo vision. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.
Skin:
Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes severe skin irritation and burns.
Ingestion:
Causes gastrointestinal tract burns. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Inhalation of high concentrations may cause narcotic effects. Can produce delayed pulmonary edema. Causes respiratory tract irritation with possible burns.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Rapidly penetrates eye tissue. Extensive flushing of the eye is recommended. Persons with asthma, chronic respiratory disease, skin disorders, eye problems or allergies may be at increased risk from exposure to this substance.
Antidote: Do not apply greases or ointments.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Rapidly penetrates eye tissue. Extensive flushing of the eye is recommended. Persons with asthma, chronic respiratory disease, skin disorders, eye problems or allergies may be at increased risk from exposure to this substance.
Antidote: Do not apply greases or ointments.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire. May be ignited by heat, sparks, and flame. Will be easily ignited by heat, sparks or flame.
Extinguishing Media:
Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. For large fires, use water spray or alcohol foam. For small fires, use carbon dioxide, dry chemical, dry sand or limestone.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire. May be ignited by heat, sparks, and flame. Will be easily ignited by heat, sparks or flame.
Extinguishing Media:
Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. For large fires, use water spray or alcohol foam. For small fires, use carbon dioxide, dry chemical, dry sand or limestone.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Store in steel containers.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Store in steel containers.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR ??1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR ??1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: colorless liquid
Odor: ammonia-like
pH: Strong Base (12.30)
Vapor Pressure: 248 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 47 deg C
Freezing/Melting Point: -83 deg C
Autoignition Temperature: 402 deg C ( 755.60 deg F)
Flash Point: -35 deg C ( -31.00 deg F)
Explosion Limits, lower: 2.00 vol %
Explosion Limits, upper: 10.4 vol %
Decomposition Temperature:
Solubility in water: Miscible.
Specific Gravity/Density: 0.694
Molecular Formula: CH3CH2CH2NH2
Molecular Weight: 59.0697
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, perchloryl fluoride, 1-chloro-1,3-epoxypropane, aldehydes, epoxides (e.g. butyl glycidyl ether), halogenated agents, mineral acids, organic acids, sodium hypochlorite, calcium hypochlorite, copper, aluminum, zinc, galvanized surfaces, peroxides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, ammonia, nitric acid.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, perchloryl fluoride, 1-chloro-1,3-epoxypropane, aldehydes, epoxides (e.g. butyl glycidyl ether), halogenated agents, mineral acids, organic acids, sodium hypochlorite, calcium hypochlorite, copper, aluminum, zinc, galvanized surfaces, peroxides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, ammonia, nitric acid.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 75-31-0: NT8400000 LD50/LC50:
CAS# 75-31-0: Draize test, rabbit, eye: 100 uL Severe; Inhalation, rat: LC50 = 4000 ppm/4H; Oral, mouse: LD50 = 2200 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 111 mg/kg; Skin, rabbit: LD50 = 380 mg/kg.
Carcinogenicity:
Isopropylamine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.
CAS# 75-31-0: NT8400000 LD50/LC50:
CAS# 75-31-0: Draize test, rabbit, eye: 100 uL Severe; Inhalation, rat: LC50 = 4000 ppm/4H; Oral, mouse: LD50 = 2200 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 111 mg/kg; Skin, rabbit: LD50 = 380 mg/kg.
Carcinogenicity:
Isopropylamine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Water flea Daphnia: EC50 = 91.5-91.6 mg/L; 48 Hr; UnspecifiedBased on the vapor pressure, isopropylamine should rapidly evaporate from dry surfaces, especially when present in high concn such as in spill situations. The miscibility of isopropylamine in water suggests that adsorption and bioconcentration, in addition to volatilization, are not important fate processes. This is supported by low estimates for the bioconcentration factor (log BCF = 0.43) and soil adsorption coefficient (Koc = 33).
Other Harmful to aquatic life in very low concentrations. Waste from this product may present long-term environmental hazards.
Water flea Daphnia: EC50 = 91.5-91.6 mg/L; 48 Hr; UnspecifiedBased on the vapor pressure, isopropylamine should rapidly evaporate from dry surfaces, especially when present in high concn such as in spill situations. The miscibility of isopropylamine in water suggests that adsorption and bioconcentration, in addition to volatilization, are not important fate processes. This is supported by low estimates for the bioconcentration factor (log BCF = 0.43) and soil adsorption coefficient (Koc = 33).
Other Harmful to aquatic life in very low concentrations. Waste from this product may present long-term environmental hazards.
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ISOPROPYLAMINE
Hazard Class: 3
UN Number: 1221
Packing Group: I
IMO
Shipping Name: ISOPROPYLAMINE
Hazard Class: 3
UN Number: 1221
Packing Group: I
RID/ADR
Shipping Name: ISOPROPYLAMINE
Dangerous Goods Code: 3(22A)
UN Number: 1221
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F+
Risk Phrases:
R 12 Extremely flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 29 Do not empty into drains.
WGK (Water Danger/Protection)
CAS# 75-31-0: 2
United Kingdom Occupational Exposure Limits
Canada
CAS# 75-31-0 is listed on Canadas DSL List.
CAS# 75-31-0 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 75-31-0: OEL-AUSTRALIA:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3
)
OEL-BELGIUM:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3)
OEL-DENMARK:TWA 5 ppm (12 mg/m3)
OEL-FRANCE:TWA 5 ppm (12 mg/m3)
OEL-GERMANY:TWA 5 ppm (12 mg/m3)
OEL-THE NETHERLANDS:TWA 5 ppm (12 mg/m3)
OEL-THE PHILIPPINES:TWA 5 ppm (12 mg/m3)
OEL-RUSSIA:STEL 1 mg/m3
OEL-SWITZERLAND:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3)
OEL-TURKEY:TWA 5 ppm (12 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 75-31-0 is listed on the TSCA inventory.
