Name:
Isopropyl-??-D-thiogalactopyranoside DNase RNase Protease free
Synonym:
IPTG ; Isopropyl-beta-D-thiogalactosid
CAS:
123-91-1
Section 1 - Chemical Product
MSDS Name:Isopropyl-??-D-thiogalactopyranoside DNase RNase Protease free
Synonym:IPTG ; Isopropyl-beta-D-thiogalactosid
Synonym:IPTG ; Isopropyl-beta-D-thiogalactosid
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 123-91-1 | 1,4-Dioxane | <1.0 | 204-661-8 |
| Hazard Symbols: XN Risk Phrases: 19 40 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
May form explosive peroxides. Limited evidence of a carcinogenic effect.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. Contact may cause transient eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
May cause cancer according to animal studies.
May form explosive peroxides. Limited evidence of a carcinogenic effect.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. Contact may cause transient eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
May cause cancer according to animal studies.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:
Antidote: None reported.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:
Antidote: None reported.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Deep freeze (below -20C). Keep containers tightly closed.
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Deep freeze (below -20C). Keep containers tightly closed.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 123-91-1: United Kingdom, WEL - TWA: 25 ppm TWA; 91 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 366 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 25 ppm VLE; 91 mg/m3 VLE France - VME: 10 ppm VME; 35 mg/m3 VME France - VLE: 40 ppm VLE; 140 mg/m3 VLE Germany: 20 ppm TWA; 73 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 36 mg/m3 OEL Malaysia: 20 ppm TWA; 72.1 mg/m3 TWA Netherlands: 22 ppm STEL; 80 mg/m3 STEL Netherlands: 11 ppm MAC; 40 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 20 ppm VLA-ED; 74 mg/m3 VLA-ED CAS# 367-93-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 123-91-1: United Kingdom, WEL - TWA: 25 ppm TWA; 91 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 366 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 25 ppm VLE; 91 mg/m3 VLE France - VME: 10 ppm VME; 35 mg/m3 VME France - VLE: 40 ppm VLE; 140 mg/m3 VLE Germany: 20 ppm TWA; 73 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 36 mg/m3 OEL Malaysia: 20 ppm TWA; 72.1 mg/m3 TWA Netherlands: 22 ppm STEL; 80 mg/m3 STEL Netherlands: 11 ppm MAC; 40 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 20 ppm VLA-ED; 74 mg/m3 VLA-ED CAS# 367-93-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 122 - 124 deg C
Autoignition Temperature: Not available.
Flash Point: > 110 deg C (> 230.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble in ethanol
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 238.30
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. May form explosive peroxides. Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Conditions to Avoid:
High temperatures, incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures. May form explosive peroxides. Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Conditions to Avoid:
High temperatures, incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 123-91-1: JG8225000 CAS# 367-93-1 unlisted.
LD50/LC50:
CAS# 123-91-1: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 100 mg/24H Moderate; Inhalation, mouse: LC50 = 37 gm/m3/2H; Inhalation, rat: LC50 = 46 gm/m3/2H; Oral, mouse: LD50 = 5300 mg/kg; Oral, rabbit: LD50 = 2 gm/kg; Oral, rat: LD50 = 4200 mg/kg; Skin, rabbit: LD50 = 7600 uL/kg.
CAS# 367-93-1.
Carcinogenicity:
1,4-Dioxane - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Isopropyl-??-D-thiogalactopyranoside, DNase, RNase, Protease free - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 123-91-1: JG8225000 CAS# 367-93-1 unlisted.
LD50/LC50:
CAS# 123-91-1: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 100 mg/24H Moderate; Inhalation, mouse: LC50 = 37 gm/m3/2H; Inhalation, rat: LC50 = 46 gm/m3/2H; Oral, mouse: LD50 = 5300 mg/kg; Oral, rabbit: LD50 = 2 gm/kg; Oral, rat: LD50 = 4200 mg/kg; Skin, rabbit: LD50 = 7600 uL/kg.
CAS# 367-93-1.
Carcinogenicity:
1,4-Dioxane - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen Isopropyl-??-D-thiogalactopyranoside, DNase, RNase, Protease free - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 123-91-1: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 19 May form explosive peroxides.
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 123-91-1: 2
CAS# 367-93-1: No information available.
Canada
CAS# 123-91-1 is listed on Canadas DSL List.
CAS# 367-93-1 is listed on Canadas DSL List.
CAS# 123-91-1 is listed on Canadas Ingredient Disclosure List.
CAS# 367-93-1 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 123-91-1 is listed on the TSCA inventory.
CAS# 367-93-1 is listed on the TSCA inventory.
