Name:
Isopropylamine
Synonym:
2-Aminopropane; 2-Propylamine; 2-Propanamine; sec-Propylamine; Monoisopropylamine
CAS:
75-31-0
Section 1 - Chemical Product
MSDS Name:Isopropylamine
Synonym:2-Aminopropane; 2-Propylamine; 2-Propanamine; sec-Propylamine; Monoisopropylamine
Synonym:2-Aminopropane; 2-Propylamine; 2-Propanamine; sec-Propylamine; Monoisopropylamine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 75-31-0 | Isopropylamine | 99 | 200-860-9 |
| Hazard Symbols: XI F+ Risk Phrases: 12 36/37/38 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Extremely flammable. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Low vapor concentrations may cause a temporary visual disturbance known as blue haze or halo vision. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.
Skin:
Harmful if absorbed through the skin. Causes severe skin irritation and burns.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns. May cause central nervous system effects.
Inhalation:
Can produce delayed pulmonary edema. Causes respiratory tract irritation with possible burns.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.
Extremely flammable. Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Low vapor concentrations may cause a temporary visual disturbance known as blue haze or halo vision. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.
Skin:
Harmful if absorbed through the skin. Causes severe skin irritation and burns.
Ingestion:
Harmful if swallowed. Causes gastrointestinal tract burns. May cause central nervous system effects.
Inhalation:
Can produce delayed pulmonary edema. Causes respiratory tract irritation with possible burns.
Chronic:
Prolonged or repeated skin contact may cause dermatitis.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extremely flammable liquid and vapor.
Vapor may cause flash fire. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back.
Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Water may be ineffective because it will not cool material below its flash point.
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extremely flammable liquid and vapor.
Vapor may cause flash fire. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back.
Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Water may be ineffective because it will not cool material below its flash point.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 75-31-0: United States OSHA: 5 ppm TWA; 12 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 12 mg/m3 VLE Belgium - STEL: 10 ppm VLE; 24 mg/m3 VLE France - VME: 5 ppm VME; 12 mg/m3 VME Germany: 5 ppm TWA; 12 mg/m3 TWA Malaysia: 5 ppm TWA; 12 mg/m3 TWA Netherlands: 5 ppm MAC; 12 mg/m3 MAC Russia: 1 mg/m3 TWA Spain: 5 ppm VLA-ED; 12 mg/m3 VLA-ED Spain: 10 ppm VLA-EC; 24 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 75-31-0: United States OSHA: 5 ppm TWA; 12 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 12 mg/m3 VLE Belgium - STEL: 10 ppm VLE; 24 mg/m3 VLE France - VME: 5 ppm VME; 12 mg/m3 VME Germany: 5 ppm TWA; 12 mg/m3 TWA Malaysia: 5 ppm TWA; 12 mg/m3 TWA Netherlands: 5 ppm MAC; 12 mg/m3 MAC Russia: 1 mg/m3 TWA Spain: 5 ppm VLA-ED; 12 mg/m3 VLA-ED Spain: 10 ppm VLA-EC; 24 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear, colorless
Odor: ammonia-like
pH: 11.8 (0.1M aq soln)
Vapor Pressure: 580 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 33-34 deg C
Freezing/Melting Point: -101 deg C
Autoignition Temperature: 402 deg C ( 755.60 deg F)
Flash Point: -37 deg C ( -34.60 deg F)
Explosion Limits, lower: 2.0 vol %
Explosion Limits, upper: 10.4 vol %
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 0.69
Molecular Formula: C3H9N
Molecular Weight: 59.11
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, ignition sources, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, ignition sources, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 75-31-0: NT8400000 LD50/LC50:
CAS# 75-31-0: Draize test, rabbit, eye: 100 uL Severe; Inhalation, rat: LC50 = 4000 ppm/4H; Oral, mouse: LD50 = 2200 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 111 mg/kg; Skin, rabbit: LD50 = 380 mg/kg.
Carcinogenicity:
Isopropylamine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 75-31-0: NT8400000 LD50/LC50:
CAS# 75-31-0: Draize test, rabbit, eye: 100 uL Severe; Inhalation, rat: LC50 = 4000 ppm/4H; Oral, mouse: LD50 = 2200 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 111 mg/kg; Skin, rabbit: LD50 = 380 mg/kg.
Carcinogenicity:
Isopropylamine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Water flea Daphnia: EC50 = 91.5-91.6 mg/L; 48 Hr; UnspecifiedBased on the vapor pressure, isopropylamine should rapidly evaporate from dry surfaces, especially when present in high concn such as in spill situations. The miscibility of isopropylamine in water suggests that adsorption and bioconcentration, in addition to volatilization, are not important fate processes. This is supported by low estimates for the bioconcentration factor (log BCF = 0.43) and soil adsorption coefficient (Koc = 33).
Water flea Daphnia: EC50 = 91.5-91.6 mg/L; 48 Hr; UnspecifiedBased on the vapor pressure, isopropylamine should rapidly evaporate from dry surfaces, especially when present in high concn such as in spill situations. The miscibility of isopropylamine in water suggests that adsorption and bioconcentration, in addition to volatilization, are not important fate processes. This is supported by low estimates for the bioconcentration factor (log BCF = 0.43) and soil adsorption coefficient (Koc = 33).
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ISOPROPYLAMINE
Hazard Class: 3 (8)
UN Number: 1221
Packing Group: I
IMO
Shipping Name: ISOPROPYLAMINE
Hazard Class: 3.1 (8)
UN Number: 1221
Packing Group: I
RID/ADR
Shipping Name: ISOPROPYLAMINE
Hazard Class: 3
UN Number: 1221
Packing group: I
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F+
Risk Phrases:
R 12 Extremely flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 29 Do not empty into drains.
WGK (Water Danger/Protection)
CAS# 75-31-0: 2
Canada
CAS# 75-31-0 is listed on Canadas DSL List.
CAS# 75-31-0 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 75-31-0 is listed on the TSCA inventory.
