Name:
Lithium diisopropylamide 2M solution in THF/n-heptane
Section 1 - Chemical Product
MSDS Name:Lithium diisopropylamide 2M solution in THF/n-heptane
Synonym:LDA.THF complex
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 100-41-4 | Ethylbenzene | 13 | 202-849-4 |
Hazard Symbols: F C N Risk Phrases: 11 19 34 50/53 65 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. May form explosive peroxides. Causes burns. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Harmful: may cause lung damage if swallowed.Air sensitive.Moisture sensitive.
Potential Health Effects
Eye:
Causes eye burns. May cause irreversible eye injury.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause circulatory system failure. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Substance poses serious aspiration hazard.
Inhalation:
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Causes chemical burns to the respiratory tract.
Chronic:
May cause liver and kidney damage. Adverse reproductive effects have been reported in animals.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extremely flammable liquid and vapor. Vapor may cause flash fire.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Do not allow contact with water. Store and handle protected from air. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Keep away from heat, sparks and flame.
Storage:
Keep away from heat, sparks, and flame. Store in a tightly closed container. Keep under a nitrogen blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Refrigerator/flammables.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 100-41-4: United Kingdom, WEL - TWA: 100 ppm TWA; 441 mg/m3 TWA United Kingdom, WEL - STEL: 125 ppm STEL; 552 mg/m3 STEL United States OSHA: 100 ppm TWA; 435 mg/m3 TWA Belgium - TWA: 100 ppm VLE; 442 mg/m3 VLE Belgium - STEL: 125 ppm VLE; 551 mg/m3 VLE France - VME: 100 ppm VME; 435 mg/m3 VME Germany: 100 ppm TWA; 440 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 217 mg/m3 OEL Malaysia: 100 ppm TWA; 434 mg/m3 TWA Netherlands: 50 ppm MAC; 215 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 100 ppm VLA-ED; 441 mg/m3 VLA-ED Spain: 200 ppm VLA-EC; 884 mg/m3 VLA-EC CAS# 108-18-9: United Kingdom, WEL - TWA: 5 ppm TWA; 21 mg/m3 TWA United Kingdom, WEL - STEL: 15 ppm STEL; 63 mg/m3 STEL United States OSHA: 5 ppm TWA; 20 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 21 mg/m3 VLE France - VME: 5 ppm VME; 20 mg/m3 VME Germany: 20 mg/m3 TWA Germany: Skin absorber Malaysia: 5 ppm TWA; 21 mg/m3 TWA Netherlands: 5 ppm MAC; 20 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 21 mg/m3 VLA-ED CAS# 109-99-9: United Kingdom, WEL - TWA: 50 ppm TWA; 150 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 300 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 599 mg/m3 VLE Belgium - STEL: 100 ppm VLE; 300 mg/m3 VLE France - VME: 200 ppm VME; 590 mg/m3 VME Germany: 50 ppm TWA; 150 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 100 ppm MAC; 300 mg/m3 MAC Russia: 100 mg/m3 TWA Spain: 50 ppm VLA-ED; 150 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 300 mg/m3 VLA-EC CAS# 142-82-5: United Kingdom, WEL - TWA: 500 ppm TWA United Kingdom, WEL - STEL: 1500 ppm STEL United States OSHA: 500 ppm TWA; 2000 mg/m3 TWA Belgium - TWA: 400 ppm VLE; 1664 mg/m3 VLE Belgium - STEL: 500 ppm VLE; 2085 mg/m3 VLE France - VME: 400 ppm VME; 1600 mg/m3 VME Germany: 500 ppm TWA; 2100 mg/m3 TWA Japan: 200 ppm OEL; 820 mg/m3 OEL Malaysia: 400 ppm TWA; 1640 mg/m3 TWA Netherlands: 400 ppm STEL; 1600 mg/m3 STEL Netherlands: 300 ppm MAC; 1200 mg/m3 MAC Spain: 500 ppm VLA-ED; 2085 mg/m3 VLA-ED CAS# 4111-54-0: CAS# 7439-95-4: Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: red-orange
Odor: Pungent
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 60 - 136 deg C @ 760 mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: -18 deg C ( -0.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: decomposes in water
Specific Gravity/Density: .7900g/cm3
Molecular Formula: C6H14LiN
Molecular Weight: 107.12
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Combines vigorously with water with the evolution of heat. May form explosive peroxides.
Conditions to Avoid:
Ignition sources, contact with water, excess heat, prolonged exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, alcohols.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, lithium hydroxide, amines, oxides of magnesium, oxides of lithium.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 100-41-4: DA0700000 CAS# 108-18-9: IM4025000 CAS# 109-99-9: LU5950000 CAS# 142-82-5: MI7700000 CAS# 4111-54-0 unlisted.
CAS# 7439-95-4: FW6475100 LD50/LC50:
CAS# 100-41-4: Draize test, rabbit, eye: 500 mg Severe; Inhalation, mouse: LC50 = 35500 mg/m3/2H; Inhalation, rat: LC50 = 55000 mg/m3/2H; Oral, rat: LD50 = 3500 mg/kg; Oral, rat: LD50 = 3500 mg/kg; Skin, rabbit: LD50 = 17800 uL/kg.
CAS# 108-18-9: Inhalation, mouse: LC50 = 4200 mg/m3/2H; Inhalation, rat: LC50 = 4800 mg/m3/2H; Oral, mouse: LD50 = 2120 mg/kg; Oral, rabbit: LD50 = 4700 mg/kg; Oral, rat: LD50 = 770 mg/kg; Skin, rabbit: LD50 = >10 gm/kg.
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg.
CAS# 142-82-5: Inhalation, rat: LC50 = 103 gm/m3/4H.
CAS# 4111-54-0.
CAS# 7439-95-4.
Not available.
Carcinogenicity:
Ethylbenzene - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 6/11/04 IARC: Group 2B carcinogen Diisopropylamine - Not listed by ACGIH, IARC, or NTP.
Tetrahydrofuran - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to n-Heptane - Not listed by ACGIH, IARC, or NTP.
Lithium diisopropylamide - Not listed by ACGIH, IARC, or NTP.
Magnesium - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Cas# 100-41-4: LC50(96Hr.) rainbow trout = 14.0 mg/L; Static Bioassay.
LC50(96Hr.) fathead minnow= 12.1 mg/L; Flow-through Bioassay.
LC50(96Hr.) Bluegill =- 150 mg/L; Static Bioassay.
EC50(48Hr.)Water Flea = 2.1 mg/L; Static Bioassay.
EC50(48Hr.)Water Flea = 2.1 mg/L; Static Bioassay.
EC50(30 min.)Photobacterium phosphoreum = 9.68 mg/L; Microtox System.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ORGANOMETALLIC COMPOUND SOLUTION, WATER-REACTIVE,
FLAMMABLE, N.O.S.*
Hazard Class: 4.3 (3)
UN Number: 3207
Packing Group: I
IMO
Shipping Name: ORGANOMETALLIC COMPOUND SOLUTION, WATER-REACTIVE,
FLAMMABLE, N.O.S.
Hazard Class: 4.3 (3)
UN Number: 3207
Packing Group: I
RID/ADR
Shipping Name: ORGANOMETALLIC COMPOUND SOLUTION, WATER-REACTIVE,
FLAMMABLE,N.O.S.
Hazard Class: 4.3
UN Number: 3207
Packing group: I
USA RQ: CAS# 100-41-4: 1000 lb final RQ; 454 kg final RQ
USA RQ: CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C N
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 34 Causes burns.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 65 Harmful: may cause lung damage if swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 100-41-4: 1
CAS# 108-18-9: 2
CAS# 109-99-9: 1
CAS# 142-82-5: 1
CAS# 4111-54-0: No information available.
CAS# 7439-95-4: No information available.
Canada
CAS# 100-41-4 is listed on Canadas DSL List.
CAS# 108-18-9 is listed on Canadas DSL List.
CAS# 109-99-9 is listed on Canadas DSL List.
CAS# 142-82-5 is listed on Canadas DSL List.
CAS# 4111-54-0 is listed on Canadas DSL List.
CAS# 7439-95-4 is listed on Canadas DSL List.
CAS# 100-41-4 is listed on Canadas Ingredient Disclosure List.
CAS# 108-18-9 is listed on Canadas Ingredient Disclosure List.
CAS# 109-99-9 is listed on Canadas Ingredient Disclosure List.
CAS# 142-82-5 is listed on Canadas Ingredient Disclosure List.
CAS# 4111-54-0 is not listed on Canadas Ingredient Disclosure List.
CAS# 7439-95-4 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-41-4 is listed on the TSCA inventory.
CAS# 108-18-9 is listed on the TSCA inventory.
CAS# 109-99-9 is listed on the TSCA inventory.
CAS# 142-82-5 is listed on the TSCA inventory.
CAS# 4111-54-0 is listed on the TSCA inventory.
CAS# 7439-95-4 is listed on the TSCA inventory.