Name:
Methyl ethyl ketone
Synonym:
2-Butanone; Ethyl methyl ketone; MEK; Methyl ethyl ketone
CAS:
78-93-3
Section 1 - Chemical Product
MSDS Name:Methyl ethyl ketone
Synonym:2-Butanone; Ethyl methyl ketone; MEK; Methyl ethyl ketone
Synonym:2-Butanone; Ethyl methyl ketone; MEK; Methyl ethyl ketone
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 78-93-3 | Methyl ethyl ketone | >99 | 201-159-0 |
| Hazard Symbols: XI F Risk Phrases: 11 36 66 67 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Irritating to eyes. Repeated exposure may cause skin dryness or cracking. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. Vapors cause eye irritation.
Skin:
May be absorbed through the skin in harmful amounts. Repeated or prolonged exposure may cause drying and cracking of the skin.
Ingestion:
May cause irritation of the digestive tract. Possible aspiration hazard. May cause central nervous system depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause central nervous system effects such as nausea and headache.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Prolonged or repeated skin contact may cause defatting and dermatitis. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen.
Chronic overexposure to vapors may cause lung damage.
Highly flammable. Irritating to eyes. Repeated exposure may cause skin dryness or cracking. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. Vapors cause eye irritation.
Skin:
May be absorbed through the skin in harmful amounts. Repeated or prolonged exposure may cause drying and cracking of the skin.
Ingestion:
May cause irritation of the digestive tract. Possible aspiration hazard. May cause central nervous system depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. May cause central nervous system effects such as nausea and headache.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Prolonged or repeated skin contact may cause defatting and dermatitis. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen.
Chronic overexposure to vapors may cause lung damage.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extremely flammable liquid and vapor. Vapor may cause flash fire. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
In case of fire, use carbon dioxide, dry chemical powder or appropriate foam. Water may be ineffective because it will not cool material below its flash point.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extremely flammable liquid and vapor. Vapor may cause flash fire. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
In case of fire, use carbon dioxide, dry chemical powder or appropriate foam. Water may be ineffective because it will not cool material below its flash point.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Avoid breathing vapor.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Avoid breathing vapor.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 78-93-3: United Kingdom, WEL - TWA: 200 ppm TWA; 600 mg/m3 TWA United Kingdom, WEL - STEL: 300 ppm STEL; 899 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 600 mg/m3 VLE Belgium - STEL: 300 ppm VLE; 900 mg/m3 VLE France - VME: 200 ppm VME; 600 mg/m3 VME Germany: 200 ppm TWA; 600 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 200 ppm MAC; 590 mg/m3 MAC Russia: 200 mg/m3 TWA Spain: 200 ppm VLA-ED; 600 mg/m3 VLA-ED Spain: 300 ppm VLA-EC; 900 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 78-93-3: United Kingdom, WEL - TWA: 200 ppm TWA; 600 mg/m3 TWA United Kingdom, WEL - STEL: 300 ppm STEL; 899 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 600 mg/m3 VLE Belgium - STEL: 300 ppm VLE; 900 mg/m3 VLE France - VME: 200 ppm VME; 600 mg/m3 VME Germany: 200 ppm TWA; 600 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 200 ppm MAC; 590 mg/m3 MAC Russia: 200 mg/m3 TWA Spain: 200 ppm VLA-ED; 600 mg/m3 VLA-ED Spain: 300 ppm VLA-EC; 900 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: sweetish odor - acetone-like
pH: Not available.
Vapor Pressure: 77.5 mm Hg @ 20 deg C
Viscosity: 0.41 cps @ 20 deg C
Boiling Point: 80 deg C @ 760 mm Hg
Freezing/Melting Point: -87 deg C
Autoignition Temperature: 404 deg C ( 759.20 deg F)
Flash Point: -7 deg C ( 19.40 deg F)
Explosion Limits, lower: 1.4 vol%@93C
Explosion Limits, upper: 11.4 vol%@93C
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 0.8050 g/ml
Molecular Formula: C4H8O
Molecular Weight: 72.11
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Becomes yellow over time.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, 2-propanol.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization: Will not occur.
Stable at room temperature in closed containers under normal storage and handling conditions. Becomes yellow over time.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, 2-propanol.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 78-93-3: EL6475000 LD50/LC50:
CAS# 78-93-3: Draize test, rabbit, eye: 80 mg; Draize test, rabbit, skin: 500 mg/24H Moderate; Draize test, rabbit, skin: 402 mg/24H Mild; Inhalation, mouse: LC50 = 32 gm/m3/4H; Inhalation, rat: LC50 = 23500 mg/m3/8H; Oral, mouse: LD50 = 3000 mg/kg; Oral, rat: LD50 = 2737 mg/kg; Skin, rabbit: LD50 = 6480 mg/kg.
Carcinogenicity:
Methyl ethyl ketone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 78-93-3: EL6475000 LD50/LC50:
CAS# 78-93-3: Draize test, rabbit, eye: 80 mg; Draize test, rabbit, skin: 500 mg/24H Moderate; Draize test, rabbit, skin: 402 mg/24H Mild; Inhalation, mouse: LC50 = 32 gm/m3/4H; Inhalation, rat: LC50 = 23500 mg/m3/8H; Oral, mouse: LD50 = 3000 mg/kg; Oral, rat: LD50 = 2737 mg/kg; Skin, rabbit: LD50 = 6480 mg/kg.
Carcinogenicity:
Methyl ethyl ketone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 3220 mg/L; 96 Hr; UnspecifiedFish: Bluegill/Sunfish: LC50 = 1690 mg/L; 96 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51.9 mg/L; 25 min; Microtox testBacteria: Phytobacterium phosphoreum: EC50 =3373 mg/L; 30 min; Microtox test
Fish: Fathead Minnow: LC50 = 3220 mg/L; 96 Hr; UnspecifiedFish: Bluegill/Sunfish: LC50 = 1690 mg/L; 96 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51.9 mg/L; 25 min; Microtox testBacteria: Phytobacterium phosphoreum: EC50 =3373 mg/L; 30 min; Microtox test
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ETHYL METHYL KETONE
Hazard Class: 3
UN Number: 1193
Packing Group: II
IMO
Shipping Name: ETHYL METHYL KETONE
Hazard Class: 3.2
UN Number: 1193
Packing Group: II
RID/ADR
Shipping Name: ETHYL METHYL KETONE
Hazard Class: 3
UN Number: 1193
Packing group: II
USA RQ: CAS# 78-93-3: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F
Risk Phrases:
R 11 Highly flammable.
R 36 Irritating to eyes.
R 66 Repeated exposure may cause skin dryness or
cracking.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
WGK (Water Danger/Protection)
CAS# 78-93-3: 1
Canada
CAS# 78-93-3 is listed on Canadas DSL List.
CAS# 78-93-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 78-93-3 is listed on the TSCA inventory.
