Name:
Methylene Blue
Synonym:
Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride; C.I. Basic Blue 9; C.I. 52015; Methylthionine chloride; Basic Lake Blue
CAS:
61-73-4
Section 1 - Chemical Product
MSDS Name:Methylene Blue
Synonym:Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride; C.I. Basic Blue 9; C.I. 52015; Methylthionine chloride; Basic Lake Blue
Synonym:Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride; C.I. Basic Blue 9; C.I. 52015; Methylthionine chloride; Basic Lake Blue
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 61-73-4 | Methylene Blue | 100 | 200-515-2 |
| Hazard Symbols: XN Risk Phrases: 22 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.
Potential Health Effects
Eye:
May cause chemical conjunctivitis. Causes eye irritation and possible injury.
Skin:
Causes skin irritation. Absorption into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause hemolytic anemia. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Repeated contact may cause corneal damage. May cause adverse reproductive effects.
Harmful if swallowed.
Potential Health Effects
Eye:
May cause chemical conjunctivitis. Causes eye irritation and possible injury.
Skin:
Causes skin irritation. Absorption into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause hemolytic anemia. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Repeated contact may cause corneal damage. May cause adverse reproductive effects.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 61-73-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 61-73-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: dark green
Odor: odorless
pH: 3-4.5 (1% aq sol)
Vapor Pressure: Negligible.
Viscosity: Not available.
Boiling Point: Decomposes.
Freezing/Melting Point: 190 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 190 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.230
Molecular Formula: C16H18ClN3S
Molecular Weight: 319.85
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, excess heat, excess light.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases, dichromates, alkali iodides, caustic alkalis.
Hazardous Decomposition Products:
Chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, excess heat, excess light.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases, dichromates, alkali iodides, caustic alkalis.
Hazardous Decomposition Products:
Chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 61-73-4: SO5600000 LD50/LC50:
CAS# 61-73-4: Oral, mouse: LD50 = 3500 mg/kg; Oral, rat: LD50 = 1180 mg/kg.
Carcinogenicity:
Methylene Blue - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 61-73-4: SO5600000 LD50/LC50:
CAS# 61-73-4: Oral, mouse: LD50 = 3500 mg/kg; Oral, rat: LD50 = 1180 mg/kg.
Carcinogenicity:
Methylene Blue - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Laboratory adsorption studies determined that Methylene Blue was strongly adsorbed to three different soils. Volatilization of Methylene Blue will not be important from moist or dry soil surfaces. If released to water, Methylene Blue would adsorb to suspended solids and sediment based upon soil adsorption studies. It will be essentially non-volatile from water surfaces. An estimated BCF value of 1.5 suggests that Methylene Blue will not bioconcentrate in aquatic organisms.
Laboratory adsorption studies determined that Methylene Blue was strongly adsorbed to three different soils. Volatilization of Methylene Blue will not be important from moist or dry soil surfaces. If released to water, Methylene Blue would adsorb to suspended solids and sediment based upon soil adsorption studies. It will be essentially non-volatile from water surfaces. An estimated BCF value of 1.5 suggests that Methylene Blue will not bioconcentrate in aquatic organisms.
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 61-73-4: 2
Canada
CAS# 61-73-4 is listed on Canadas DSL List.
CAS# 61-73-4 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 61-73-4 is listed on the TSCA inventory.
