Name:
Methylmagnesium chloride 22 wt% solution in tetrahydrofuran (THF)
Synonym:
Magnesium, chloromethyl
CAS:
109-99-9
Section 1 - Chemical Product
MSDS Name:Methylmagnesium chloride 22 wt% solution in tetrahydrofuran (THF)
Synonym:Magnesium, chloromethyl
Synonym:Magnesium, chloromethyl
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 109-99-9 | Tetrahydrofuran | 78 | 203-726-8 |
| Hazard Symbols: F C Risk Phrases: 11 15 19 34 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Contact with water liberates extremely flammable gases. May form explosive peroxides. Causes burns.Corrosive.Water-reactive.
Potential Health Effects
Eye:
Causes eye burns. When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May be harmful if swallowed. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. May cause effects similar to those described for ingestion. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Chronic:
Effects may be delayed.
Highly flammable. Contact with water liberates extremely flammable gases. May form explosive peroxides. Causes burns.Corrosive.Water-reactive.
Potential Health Effects
Eye:
Causes eye burns. When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May be harmful if swallowed. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. May cause effects similar to those described for ingestion. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Chronic:
Effects may be delayed.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician:
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May ignite or explode on contact with steam or moist air.
Extinguishing Media:
Use dry sand or earth to smother fire. Do NOT use water directly on fire. Do NOT use carbon dioxide. Use dry chemical to fight fire. DO NOT USE WATER! Contact professional fire-fighters immediately.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May ignite or explode on contact with steam or moist air.
Extinguishing Media:
Use dry sand or earth to smother fire. Do NOT use water directly on fire. Do NOT use carbon dioxide. Use dry chemical to fight fire. DO NOT USE WATER! Contact professional fire-fighters immediately.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Remove all sources of ignition. Use a spark-proof tool. Do not expose spill to water.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Remove all sources of ignition. Use a spark-proof tool. Do not expose spill to water.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous.
Keep away from heat, sparks and flame. Do not ingest or inhale. Use and store under nitrogen. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam. Do not distill since this removes peroxide-inhibitors. Store absolutely dry.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Flammables-area. Water free area. Vent periodically.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous.
Keep away from heat, sparks and flame. Do not ingest or inhale. Use and store under nitrogen. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam. Do not distill since this removes peroxide-inhibitors. Store absolutely dry.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Flammables-area. Water free area. Vent periodically.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 109-99-9: United Kingdom, WEL - TWA: 50 ppm TWA; 150 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 300 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 599 mg/m3 VLE Belgium - STEL: 100 ppm VLE; 300 mg/m3 VLE France - VME: 200 ppm VME; 590 mg/m3 VME Germany: 50 ppm TWA; 150 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 100 ppm MAC; 300 mg/m3 MAC Russia: 100 mg/m3 TWA Spain: 50 ppm VLA-ED; 150 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 300 mg/m3 VLA-EC CAS# 676-58-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 109-99-9: United Kingdom, WEL - TWA: 50 ppm TWA; 150 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 300 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 599 mg/m3 VLE Belgium - STEL: 100 ppm VLE; 300 mg/m3 VLE France - VME: 200 ppm VME; 590 mg/m3 VME Germany: 50 ppm TWA; 150 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 100 ppm MAC; 300 mg/m3 MAC Russia: 100 mg/m3 TWA Spain: 50 ppm VLA-ED; 150 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 300 mg/m3 VLA-EC CAS# 676-58-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: dark
Odor: None reported.
pH: Not available.
Vapor Pressure: 143 mm Hg @20 deg C
Viscosity: Not available.
Boiling Point: 66 deg C @ 760.00mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: 212 deg C ( 413.60 deg F)
Flash Point: -17 deg C ( 1.40 deg F)
Explosion Limits, lower: 1.50 vol %
Explosion Limits, upper: 12.00 vol %
Decomposition Temperature: Not available.
Solubility in water: reacts
Specific Gravity/Density: 1.0300g/cm3
Molecular Formula: CH3ClMg
Molecular Weight: 74.79
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Combines vigorously or explosively with water. Tetrahydrofuran will auto oxidize in the presence of light and oxygen to form resinous products.
Conditions to Avoid:
Incompatible materials, ignition sources, exposure to air, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Oxidizing agents, acids, alcohols, oxygen, water.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures. Combines vigorously or explosively with water. Tetrahydrofuran will auto oxidize in the presence of light and oxygen to form resinous products.
Conditions to Avoid:
Incompatible materials, ignition sources, exposure to air, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Oxidizing agents, acids, alcohols, oxygen, water.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 109-99-9: LU5950000 CAS# 676-58-4 unlisted.
LD50/LC50:
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg.
CAS# 676-58-4.
Carcinogenicity:
Tetrahydrofuran - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to Methylmagnesium chloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 109-99-9: LU5950000 CAS# 676-58-4 unlisted.
LD50/LC50:
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg.
CAS# 676-58-4.
Carcinogenicity:
Tetrahydrofuran - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to Methylmagnesium chloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
CAS# 109-99-9: LC50 Pimephales promelas (fathead minnow) 2160 mg/l 96 hr flow-through bioassay, wt 0.12 g, water hardness 45.5 mg/l CaCO3, temp: 25 (+/- 1)C, pH 7.5, dissolved oxygen greater than 60% of saturation.
CAS# 109-99-9: LC50 Pimephales promelas (fathead minnow) 2160 mg/l 96 hr flow-through bioassay, wt 0.12 g, water hardness 45.5 mg/l CaCO3, temp: 25 (+/- 1)C, pH 7.5, dissolved oxygen greater than 60% of saturation.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: WATER-REACTIVE SOLID, N.O.S.*
Hazard Class: 4.3
UN Number: 2813
Packing Group: I
IMO
Shipping Name: WATER-REACTIVE SOLID, N.O.S.
Hazard Class: 4.3
UN Number: 2813
Packing Group: I
RID/ADR
Shipping Name: WATER-REACTIVE SOLID, N.O.S.
Hazard Class: 4.3
UN Number: 2813
Packing group: I
USA RQ: CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C
Risk Phrases:
R 11 Highly flammable.
R 15 Contact with water liberates extremely
flammable gases.
R 19 May form explosive peroxides.
R 34 Causes burns.
Safety Phrases:
S 7/8 Keep container tightly closed and dry.
S 16 Keep away from sources of ignition - No
smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static
discharges.
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
CAS# 676-58-4: No information available.
Canada
CAS# 109-99-9 is listed on Canadas DSL List.
CAS# 676-58-4 is listed on Canadas DSL List.
CAS# 109-99-9 is listed on Canadas Ingredient Disclosure List.
CAS# 676-58-4 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 109-99-9 is listed on the TSCA inventory.
CAS# 676-58-4 is listed on the TSCA inventory.
