Name:
Morpholine
Synonym:
Diethylene imidoxide; Diethylene oximide; 1-Oxa-4-azacyclohexane; Tetrahydro-1,4-oxazine
CAS:
110-91-8
Section 1 - Chemical Product
MSDS Name:Morpholine
Synonym:Diethylene imidoxide; Diethylene oximide; 1-Oxa-4-azacyclohexane; Tetrahydro-1,4-oxazine
Synonym:Diethylene imidoxide; Diethylene oximide; 1-Oxa-4-azacyclohexane; Tetrahydro-1,4-oxazine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 110-91-8 | Morpholine | >99.0 | 203-815-1 |
| Hazard Symbols: F C Risk Phrases: 10 20/21/22 34 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Harmful by inhalation, in contact with skin and if swallowed. Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. Vapor or mist may cause irritation and severe burns. Contact with liquid is corrosive to the eyes and causes severe burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration. Substance is rapidly absorbed through the skin. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract.
Aspiration hazard. Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Inhalation:
Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
Flammable. Harmful by inhalation, in contact with skin and if swallowed. Causes burns.Corrosive.
Potential Health Effects
Eye:
Causes eye burns. Vapor or mist may cause irritation and severe burns. Contact with liquid is corrosive to the eyes and causes severe burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration. Substance is rapidly absorbed through the skin. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract.
Aspiration hazard. Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Inhalation:
Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 110-91-8: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 30 ppm STEL; 109 mg/m3 STEL United States OSHA: 20 ppm TWA; 70 mg/m3 TWA Belgium - TWA: 20 ppm VLE; 72 mg/m3 VLE France - VME: 20 ppm VME; 70 mg/m3 VME France - VLE: 30 ppm VLE; 105 mg/m3 VLE Germany: 10 ppm TWA; 36 mg/m3 TWA Germany: Skin absorber Malaysia: 20 ppm TWA; 71 mg/m3 TWA Netherlands: 20 ppm MAC; 70 mg/m3 MAC Russia: 1.5 mg/m3 TWA Russia: 0.5 mg/m3 STEL Spain: 10 ppm VLA-ED; 36 mg/m3 VLA-ED Spain: 20 ppm VLA-EC; 72 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles. Wear safety glasses and chemical goggles if splashing is possible.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 110-91-8: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 30 ppm STEL; 109 mg/m3 STEL United States OSHA: 20 ppm TWA; 70 mg/m3 TWA Belgium - TWA: 20 ppm VLE; 72 mg/m3 VLE France - VME: 20 ppm VME; 70 mg/m3 VME France - VLE: 30 ppm VLE; 105 mg/m3 VLE Germany: 10 ppm TWA; 36 mg/m3 TWA Germany: Skin absorber Malaysia: 20 ppm TWA; 71 mg/m3 TWA Netherlands: 20 ppm MAC; 70 mg/m3 MAC Russia: 1.5 mg/m3 TWA Russia: 0.5 mg/m3 STEL Spain: 10 ppm VLA-ED; 36 mg/m3 VLA-ED Spain: 20 ppm VLA-EC; 72 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles. Wear safety glasses and chemical goggles if splashing is possible.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear, colorless
Odor: characteristic odor - amine-like
pH: >7.0 (basic).
Vapor Pressure: 6.6 mm Hg @ 20
Viscosity: 2.23 cP 20 C
Boiling Point: 262 deg F
Freezing/Melting Point: 23 deg F
Autoignition Temperature: 555 deg F ( 290.56 deg C)
Flash Point: 98 deg F ( 36.67 deg C)
Explosion Limits, lower: 1.4
Explosion Limits, upper: 11.2
Decomposition Temperature: 489 F
Solubility in water: >500 mg/l (20 C)
Specific Gravity/Density: 1.0 (water=1)
Molecular Formula: C4H9NO
Molecular Weight: 87.0691
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Ignition sources, metals, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, alcohols, phenols, vinyl acetate, isocyanates, alkylene oxides, organic anhydrides, epichlorohydrin, cresol, aldehydes, ketones, acrylates, substituted allyls, glycols, caprolactam solution.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia and/or derivatives.
Hazardous Polymerization: Has not been reported.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Ignition sources, metals, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, alcohols, phenols, vinyl acetate, isocyanates, alkylene oxides, organic anhydrides, epichlorohydrin, cresol, aldehydes, ketones, acrylates, substituted allyls, glycols, caprolactam solution.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia and/or derivatives.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 110-91-8: QD6475000 LD50/LC50:
CAS# 110-91-8: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, skin: 995 mg/24H Severe; Inhalation, mouse: LC50 = 1320 mg/m3/2H; Inhalation, rat: LC50 = 8000 ppm/8H; Oral, mouse: LD50 = 525 mg/kg; Oral, rat: LD50 = 1450 mg/kg; Skin, rabbit: LD50 = 500 uL/kg.
Carcinogenicity:
Morpholine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 110-91-8: QD6475000 LD50/LC50:
CAS# 110-91-8: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, skin: 995 mg/24H Severe; Inhalation, mouse: LC50 = 1320 mg/m3/2H; Inhalation, rat: LC50 = 8000 ppm/8H; Oral, mouse: LD50 = 525 mg/kg; Oral, rat: LD50 = 1450 mg/kg; Skin, rabbit: LD50 = 500 uL/kg.
Carcinogenicity:
Morpholine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = 350.0 mg/L; 96 Hr.; Static conditions, 18-22 degrees CWater flea Daphnia: LC50 = 100.0-119.0 mg/L; 24 Hr.; UnspecifiedAlgae: EC50 = 28.0 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 57.0 mg/L; 30 minutes; Microtox test
Fish: Bluegill/Sunfish: LC50 = 350.0 mg/L; 96 Hr.; Static conditions, 18-22 degrees CWater flea Daphnia: LC50 = 100.0-119.0 mg/L; 24 Hr.; UnspecifiedAlgae: EC50 = 28.0 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 57.0 mg/L; 30 minutes; Microtox test
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: MORPHOLINE
Hazard Class: 8
UN Number: 2054
Packing Group: I
IMO
Shipping Name: MORPHOLINE
Hazard Class: 8
UN Number: 2054
Packing Group: I
RID/ADR
Shipping Name: MORPHOLINE
Hazard Class: 3
UN Number: 2054
Packing group: III
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C
Risk Phrases:
R 10 Flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 36 Wear suitable protective clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 110-91-8: 2
Canada
CAS# 110-91-8 is listed on Canadas DSL List.
CAS# 110-91-8 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-91-8 is listed on the TSCA inventory.
