Name:
N N -Dicyclohexylcarbodiimide 25% solution in acetone
Synonym:
CAS:
67-64-1
Section 1 - Chemical Product
MSDS Name:N N -Dicyclohexylcarbodiimide 25% solution in acetone
Synonym:
Synonym:
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-64-1 | Acetone | 75 | 200-662-2 |
| Hazard Symbols: T F Risk Phrases: 11 22 24 41 43 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Harmful if swallowed. Toxic in contact with skin.
Risk of serious damage to eyes. May cause sensitization by skin contact.
Potential Health Effects
Eye:
May cause eye irritation and possible damage.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Toxic in contact with skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause central nervous system depression, kidney damage, and liver damage.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation.
Chronic:
Not available.
Highly flammable. Harmful if swallowed. Toxic in contact with skin.
Risk of serious damage to eyes. May cause sensitization by skin contact.
Potential Health Effects
Eye:
May cause eye irritation and possible damage.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Toxic in contact with skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause central nervous system depression, kidney damage, and liver damage.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation.
Chronic:
Not available.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.
Section 7 - HANDLING and STORAGE
Handling:
Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Flammables-area.
Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 67-64-1: United Kingdom, WEL - TWA: 500 ppm TWA; 1210 mg/m3 TWA United Kingdom, WEL - STEL: 1500 ppm STEL; 3620 mg/m3 STEL United States OSHA: 1000 ppm TWA; 2400 mg/m3 TWA Belgium - TWA: 500 ppm VLE; 1210 mg/m3 VLE Belgium - STEL: 1000 ppm VLE; 2420 mg/m3 VLE France - VME: 750 ppm VME; 1800 mg/m3 VME Germany: 500 ppm TWA; 1200 mg/m3 TWA Japan: 200 ppm OEL; 470 mg/m3 OEL Malaysia: 500 ppm TWA; 1187 mg/m3 TWA Netherlands: 750 ppm MAC; 1780 mg/m3 MAC Russia: 200 mg/m3 TWA Spain: 500 ppm VLA-ED; 1210 mg/m3 VLA-ED CAS# 538-75-0: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 67-64-1: United Kingdom, WEL - TWA: 500 ppm TWA; 1210 mg/m3 TWA United Kingdom, WEL - STEL: 1500 ppm STEL; 3620 mg/m3 STEL United States OSHA: 1000 ppm TWA; 2400 mg/m3 TWA Belgium - TWA: 500 ppm VLE; 1210 mg/m3 VLE Belgium - STEL: 1000 ppm VLE; 2420 mg/m3 VLE France - VME: 750 ppm VME; 1800 mg/m3 VME Germany: 500 ppm TWA; 1200 mg/m3 TWA Japan: 200 ppm OEL; 470 mg/m3 OEL Malaysia: 500 ppm TWA; 1187 mg/m3 TWA Netherlands: 750 ppm MAC; 1780 mg/m3 MAC Russia: 200 mg/m3 TWA Spain: 500 ppm VLA-ED; 1210 mg/m3 VLA-ED CAS# 538-75-0: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: -20 deg C ( -4.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C13H22N2
Molecular Weight: 206.1674
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-64-1: AL3150000 CAS# 538-75-0: FF2160000 LD50/LC50:
CAS# 67-64-1: Dermal, guinea pig: LD50 = >9400 uL/kg; Draize test, rabbit, eye: 20 mg Severe; Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, eye: 10 uL Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 44 gm/m3/4H; Inhalation, rat: LC50 = 50100 mg/m3/8H; Oral, mouse: LD50 = 3 gm/kg; Oral, rabbit: LD50 = 5340 mg/kg; Oral, rat: LD50 = 5800 mg/kg.
CAS# 538-75-0: Dermal, guinea pig: LD50 = 10 mL/kg; Inhalation, rat: LC50 = 159 mg/m3/6H; Oral, mouse: LD50 = >800 mg/kg; Oral, rat: LD50 = 400 mg/kg.
Carcinogenicity:
Acetone - Not listed by ACGIH, IARC, or NTP.
N,N-Dicyclohexylcarbodiimide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 67-64-1: AL3150000 CAS# 538-75-0: FF2160000 LD50/LC50:
CAS# 67-64-1: Dermal, guinea pig: LD50 = >9400 uL/kg; Draize test, rabbit, eye: 20 mg Severe; Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, eye: 10 uL Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 44 gm/m3/4H; Inhalation, rat: LC50 = 50100 mg/m3/8H; Oral, mouse: LD50 = 3 gm/kg; Oral, rabbit: LD50 = 5340 mg/kg; Oral, rat: LD50 = 5800 mg/kg.
CAS# 538-75-0: Dermal, guinea pig: LD50 = 10 mL/kg; Inhalation, rat: LC50 = 159 mg/m3/6H; Oral, mouse: LD50 = >800 mg/kg; Oral, rat: LD50 = 400 mg/kg.
Carcinogenicity:
Acetone - Not listed by ACGIH, IARC, or NTP.
N,N-Dicyclohexylcarbodiimide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
USA RQ: CAS# 67-64-1: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 22 Harmful if swallowed.
R 24 Toxic in contact with skin.
R 41 Risk of serious damage to eyes.
R 43 May cause sensitization by skin contact.
Safety Phrases:
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 23 Do not inhale gas/fumes/vapour/spray.
S 24 Avoid contact with skin.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 33 Take precautionary measures against static
discharges.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 67-64-1: 0
CAS# 538-75-0: 2
Canada
CAS# 67-64-1 is listed on Canadas DSL List.
CAS# 538-75-0 is listed on Canadas DSL List.
CAS# 67-64-1 is listed on Canadas Ingredient Disclosure List.
CAS# 538-75-0 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-64-1 is listed on the TSCA inventory.
CAS# 538-75-0 is listed on the TSCA inventory.
