MSDS Name:N N-Dimethylformamide DNase RNase Protease free
Synonym:N,N-Dimethylmethanamide; DMF; DMF

EMERGENCY OVERVIEW
Harmful by inhalation and in contact with skin. Irritating to eyes.
May cause harm to the unborn child.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Substance is rapidly absorbed through the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause liver damage.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis.

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible liquid.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Do not flush into a sewer. Remove all sources of ignition.

Handling:
Use only in a well-ventilated area. Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container.

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 68-12-2: United Kingdom, OES - TWA: 10 ppm TWA; 30 mg/m3 TWA United Kingdom, OES - STEL: 20 ppm STEL; 61 mg/m3 STEL United States OSHA: 10 ppm TWA; 30 mg/m3 TWA Belgium - TWA: 10 ppm VLE; 30 mg/m3 VLE France - VME: 10 ppm VME; 30 mg/m3 VME Germany: 10 ppm TWA; 30 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 30 mg/m3 OEL Malaysia: 10 ppm TWA; 30 mg/m3 TWA Netherlands: 5 ppm MAC; 15 mg/m3 MAC Russia: 10 mg/m3 TWA Spain: 10 ppm VLA-ED; 30 mg/m3 VLA-ED Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Physical State: Clear liquid
Color: APHA: 5 max
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: 0.8 mPas 20 deg C
Boiling Point: 153 deg C @ 760.00m
Freezing/Melting Point: -61 deg C
Autoignition Temperature: 445 deg C ( 833.00 deg F)
Flash Point: 58 deg C ( 136.40 deg F)
Explosion Limits, lower: 2.20 vol %
Explosion Limits, upper: 16.00 vol %
Decomposition Temperature: >350 deg C
Solubility in water: halogenated hydrocarbons)
Specific Gravity/Density: .9450g/cm3
Molecular Formula:
Molecular Weight: 73.09

Chemical Stability:
Stable.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, halogenated agents, nitrates, chloroformates.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, carbon dioxide.
Hazardous Polymerization: Not available.

RTECS#:
CAS# 68-12-2: LQ2100000 LD50/LC50:
CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Inhalation, rat: LC50 = 3421 ppm/1H; Inhalation, rat: LC50 = 3421 ppm/3H; Inhalation, rat: LC50 = 1948 ppm/4H; Oral, mouse: LD50 = 2900 mg/kg; Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin, rabbit: LD50 = 4720 mg/kg; Skin, rat: LD50 = >3.2 gm/kg.
Carcinogenicity:
N,N-Dimethylformamide, DNase, RNase, Protease free - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Ecotoxicity:
Damage to fish: Gold oland test: 18 hrs LC50: 500 mg/l

Dispose of in a manner consistent with federal, state, and local regulations.

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
USA RQ: CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 61 May cause harm to the unborn child.
R 20/21 Harmful by inhalation and in contact with
skin.
R 36 Irritating to eyes.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 68-12-2: 1
Canada
CAS# 68-12-2 is listed on Canadas DSL List.
CAS# 68-12-2 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 68-12-2 is listed on the TSCA inventory.