Name:
n-Butyllithium 2.5M solution in hexanes
Synonym:
None
CAS:
109-72-8
Section 1 - Chemical Product
MSDS Name:n-Butyllithium 2.5M solution in hexanes
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 109-72-8 | n-Butyllithium | 12-15 | 203-698-7 |
| Hazard Symbols: F C Risk Phrases: 11 14/15 17 34 48/20 62 51/53 65 67 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Reacts violently with water liberating extremely flammable gases. Spontaneously flammable in air. Causes burns.
Harmful : danger of serious damage to health by prolonged exposure through inhalation. Possible risk of impaired fertility. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness.Water-reactive.Corrosive.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes severe eye burns. May cause irreversible eye injury.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration.
Ingestion:
Aspiration hazard. May cause central nervous system depression, kidney damage, and liver damage. Causes digestive tract burns with immediate pain, swelling of the throat, convulsions, and possible coma. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause corrosion and permanent tissue destruction of the esophagus and digestive tract.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Irritation may lead to chemical pneumonitis and pulmonary edema. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause effects similar to those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Chronic exposure may cause kidney damage.
Highly flammable. Reacts violently with water liberating extremely flammable gases. Spontaneously flammable in air. Causes burns.
Harmful : danger of serious damage to health by prolonged exposure through inhalation. Possible risk of impaired fertility. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness.Water-reactive.Corrosive.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes severe eye burns. May cause irreversible eye injury.
Skin:
Contact with liquid is corrosive and causes severe burns and ulceration.
Ingestion:
Aspiration hazard. May cause central nervous system depression, kidney damage, and liver damage. Causes digestive tract burns with immediate pain, swelling of the throat, convulsions, and possible coma. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause corrosion and permanent tissue destruction of the esophagus and digestive tract.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Irritation may lead to chemical pneumonitis and pulmonary edema. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May cause effects similar to those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Chronic exposure may cause kidney damage.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
Evacuate area and fight fire from a safe distance. Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Vapors can travel to a source of ignition and flash back. Combustion generates toxic fumes. Material is easily ignited if allowed to dry.
Extremely flammable. Material will readily ignite at room temperature. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Can form explosive mixtures at temperatures above the flashpoint. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Water may be ineffective. Do NOT use carbon dioxide. DO NOT USE WATER! Use dry chemical. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
Evacuate area and fight fire from a safe distance. Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Vapors can travel to a source of ignition and flash back. Combustion generates toxic fumes. Material is easily ignited if allowed to dry.
Extremely flammable. Material will readily ignite at room temperature. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Can form explosive mixtures at temperatures above the flashpoint. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Water may be ineffective. Do NOT use carbon dioxide. DO NOT USE WATER! Use dry chemical. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition.
Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition.
Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed.
Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Store and handle protected from air. Do not use if the material has evaporated to dryness. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed to prevent drying out. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Keep away from organic halogens.
Refrigerator/flammables.
Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed.
Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Store and handle protected from air. Do not use if the material has evaporated to dryness. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed to prevent drying out. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Keep away from organic halogens.
Refrigerator/flammables.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 109-72-8: CAS# 110-54-3: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 60 ppm STEL; 216 mg/m3 STEL United States OSHA: 500 ppm TWA; 1800 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 179 mg/m3 VLE France - VME: 50 ppm VME; 170 mg/m3 VME Germany: 50 ppm TWA; 180 mg/m3 TWA Japan: 40 ppm OEL; 140 mg/m3 OEL Malaysia: 50 ppm TWA; 176 mg/m3 TWA Netherlands: 25 ppm MAC; 90 mg/m3 MAC Russia: 300 mg/m3 TWA Spain: 50 ppm VLA-ED; 179 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 109-72-8: CAS# 110-54-3: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 60 ppm STEL; 216 mg/m3 STEL United States OSHA: 500 ppm TWA; 1800 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 179 mg/m3 VLE France - VME: 50 ppm VME; 170 mg/m3 VME Germany: 50 ppm TWA; 180 mg/m3 TWA Japan: 40 ppm OEL; 140 mg/m3 OEL Malaysia: 50 ppm TWA; 176 mg/m3 TWA Netherlands: 25 ppm MAC; 90 mg/m3 MAC Russia: 300 mg/m3 TWA Spain: 50 ppm VLA-ED; 179 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid/Liquid Mixture
Color: clear yellow
Odor: hexane-like
pH: Not available.
Vapor Pressure: 160 mbar @ 20 deg C
Viscosity: 0.38mPas 20 deg C
Boiling Point: 60 - 80 deg C @ 760.00mm Hg
Freezing/Melting Point: -95 deg C
Autoignition Temperature: 240 deg C ( 464.00 deg F)
Flash Point: -21 deg C ( -5.80 deg F)
Explosion Limits, lower: 1.20 vol %
Explosion Limits, upper: 7.40 vol %
Decomposition Temperature:
Solubility in water: reacts
Specific Gravity/Density: .6800g/cm3
Molecular Formula: C4H9Li
Molecular Weight: 64.06
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, exposure to air, contact with water, organic materials, strong oxidants, exposure to moist air or water, dehydrating agents.
Incompatibilities with Other Materials:
Lithium is incompatible with acetonitrile + sulfur dioxide, bromine pentafluoride, bromobenzene, carbon + lithium tetrachloroaluminate + sulfunyl chloride, carbon + sulfunyl chloride, chlorine tri or pentafluoride, diazomethane, diborane, ethylene, halocarbbons, halogens, hydrogen, mercury, metal chlorides + nitrogen, metal oxides and chalcogenides, metals, nitric acid, nitryly fluoride, non-metal oxides, platinum, pol(1,1-difluoroethylene-hexafluoropropylene) (viton), sodium carbonate, sulfur, sulfinyl chloride, sulfur dioxide, trifluoromethyl hypofluorite, halocarbons, halogens, iron(II) sulfide, manganese telluride, arsenic, beryllium, maleic anhydride, carbides, carbon dioxide, + water, chlorine, chromium, chromium trichloride, cobalt alloys, nickel alloys, nitrogen, organic matter, oxygen, phosphorus, rubber, silicates, sodium nitrite, tantalum (V) oxide, vanadium, zirconium tetrachloride, iodoform, nitrogen + metal chlorides, fluorine, magnesium perchlorate. Butyl lithium above 20% in air can ignite spontaneously if the humidity exceeds 70%.
Concentrations above 25% are pyrophoric at any humidity. Hexane is incompatible with dinitrogen tetraoxide.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, lithium hydroxide, butane, oxides of lithium.
Hazardous Polymerization: Has not been reported.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, exposure to air, contact with water, organic materials, strong oxidants, exposure to moist air or water, dehydrating agents.
Incompatibilities with Other Materials:
Lithium is incompatible with acetonitrile + sulfur dioxide, bromine pentafluoride, bromobenzene, carbon + lithium tetrachloroaluminate + sulfunyl chloride, carbon + sulfunyl chloride, chlorine tri or pentafluoride, diazomethane, diborane, ethylene, halocarbbons, halogens, hydrogen, mercury, metal chlorides + nitrogen, metal oxides and chalcogenides, metals, nitric acid, nitryly fluoride, non-metal oxides, platinum, pol(1,1-difluoroethylene-hexafluoropropylene) (viton), sodium carbonate, sulfur, sulfinyl chloride, sulfur dioxide, trifluoromethyl hypofluorite, halocarbons, halogens, iron(II) sulfide, manganese telluride, arsenic, beryllium, maleic anhydride, carbides, carbon dioxide, + water, chlorine, chromium, chromium trichloride, cobalt alloys, nickel alloys, nitrogen, organic matter, oxygen, phosphorus, rubber, silicates, sodium nitrite, tantalum (V) oxide, vanadium, zirconium tetrachloride, iodoform, nitrogen + metal chlorides, fluorine, magnesium perchlorate. Butyl lithium above 20% in air can ignite spontaneously if the humidity exceeds 70%.
Concentrations above 25% are pyrophoric at any humidity. Hexane is incompatible with dinitrogen tetraoxide.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, lithium hydroxide, butane, oxides of lithium.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 109-72-8 unlisted.
CAS# 110-54-3: MN9275000 LD50/LC50:
Not available.
CAS# 110-54-3: Draize test, rabbit, eye: 10 mg Mild; Inhalation, mouse: LC50 = 150000 mg/m3/2H; Inhalation, rat: LC50 = 48000 ppm/4H; Inhalation, rat: LC50 = 627000 mg/m3/3M; Oral, rat: LD50 = 25 gm/kg.
Carcinogenicity:
n-Butyllithium - Not listed by ACGIH, IARC, or NTP.
Hexane - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 109-72-8 unlisted.
CAS# 110-54-3: MN9275000 LD50/LC50:
Not available.
CAS# 110-54-3: Draize test, rabbit, eye: 10 mg Mild; Inhalation, mouse: LC50 = 150000 mg/m3/2H; Inhalation, rat: LC50 = 48000 ppm/4H; Inhalation, rat: LC50 = 627000 mg/m3/3M; Oral, rat: LD50 = 25 gm/kg.
Carcinogenicity:
n-Butyllithium - Not listed by ACGIH, IARC, or NTP.
Hexane - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Cas# 110-54-3: LC50(96Hr.) Rainbow Trout = 4.14 mg/L; Flow-through Bioassay LC50(96Hr.)Fathead Minnow=5.10 mg/L LC50(96Hr.)Bluegill = 4.12 mg/L LC50 (48Hr.) Water Flea = 3.87 mg/L
Cas# 110-54-3: LC50(96Hr.) Rainbow Trout = 4.14 mg/L; Flow-through Bioassay LC50(96Hr.)Fathead Minnow=5.10 mg/L LC50(96Hr.)Bluegill = 4.12 mg/L LC50 (48Hr.) Water Flea = 3.87 mg/L
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2 (4.3)
UN Number: 2445
Packing Group:
IMO
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2 (4.3)
UN Number: 2445
Packing Group: I
RID/ADR
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2
UN Number: 2445
Packing group: I
USA RQ: CAS# 110-54-3: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C
Risk Phrases:
R 11 Highly flammable.
R 14/15 Reacts violently with water liberating
extremely flammable gases.
R 17 Spontaneously flammable in air.
R 34 Causes burns.
R 48/20 Harmful : danger of serious damage to health
by prolonged exposure through inhalation.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 62 Possible risk of impaired fertility.
R 65 Harmful: may cause lung damage if swallowed.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 6A Keep under nitrogen.
S 16 Keep away from sources of ignition - No
smoking.
S 33 Take precautionary measures against static
discharges.
S 43B In case of fire, use fire-fighting equipment
on basis of sodium chloride, sodium bicarbonate (never
use water).
WGK (Water Danger/Protection)
CAS# 109-72-8: 2
CAS# 110-54-3: 1
Canada
CAS# 109-72-8 is listed on Canadas DSL List.
CAS# 110-54-3 is listed on Canadas DSL List.
CAS# 109-72-8 is not listed on Canadas Ingredient Disclosure List.
CAS# 110-54-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 109-72-8 is listed on the TSCA inventory.
CAS# 110-54-3 is listed on the TSCA inventory.
