Name:
N-Methylpyrrolidone peptide synthesis grade
Synonym:
N-Methylpyrrolidone; NM
CAS:
872-50-4
Section 1 - Chemical Product
MSDS Name:N-Methylpyrrolidone peptide synthesis grade
Synonym:N-Methylpyrrolidone; NM
Synonym:N-Methylpyrrolidone; NM
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 872-50-4 | N-Methylpyrrolidone | 212-828-1 |
| Hazard Symbols: XI Risk Phrases: 36/38 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes and skin.Hygroscopic.Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Inhalation of vapor may cause respiratory tract irritation. May cause abdominal pain, nausea, vomiting, and inflammation of the gums and mouth.
Chronic:
Not available.
Irritating to eyes and skin.Hygroscopic.Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Inhalation of vapor may cause respiratory tract irritation. May cause abdominal pain, nausea, vomiting, and inflammation of the gums and mouth.
Chronic:
Not available.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure to fresh air immediately.
Notes to Physician:
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure to fresh air immediately.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible Liquid.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible Liquid.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.
Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Keep under a nitrogen blanket.
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Keep under a nitrogen blanket.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear a chemical apron.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear a chemical apron.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Clear liquid
Appearance: almost colorless
Odor: amine-like - mild odor
pH: 7.7-8 @100g/l aq.sol
Vapor Pressure: .7 mbar @ 25 deg C
Viscosity: 1.67 mPas 20 deg C
Boiling Point: 202 deg C @ 760.00mm Hg
Freezing/Melting Point: -24 deg C
Autoignition Temperature: 346 deg C ( 654.80 deg F)
Flash Point: 91 deg C ( 195.80 deg F)
Explosion Limits, lower: .10 vol %
Explosion Limits, upper: .01 vol %
Decomposition Temperature:
Solubility in water: miscible
Specific Gravity/Density: 1.03
Molecular Formula: C5H9NO
Molecular Weight: 99.13
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, light, temperatures above 100C, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, light, temperatures above 100C, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 872-50-4: UY5790000 LD50/LC50:
CAS# 872-50-4: Draize test, rabbit, eye: 100 mg Moderate; Oral, mouse: LD50 = 5130 mg/kg; Oral, rat: LD50 = 3914 mg/kg; Skin, rabbit: LD50 = 8 gm/kg.
Carcinogenicity:
N-Methylpyrrolidone - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 872-50-4: UY5790000 LD50/LC50:
CAS# 872-50-4: Draize test, rabbit, eye: 100 mg Moderate; Oral, mouse: LD50 = 5130 mg/kg; Oral, rat: LD50 = 3914 mg/kg; Skin, rabbit: LD50 = 8 gm/kg.
Carcinogenicity:
N-Methylpyrrolidone - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Biodegradation: 73% (28d) log Pow: -0.46 BCF: 0.16
Biodegradation: 73% (28d) log Pow: -0.46 BCF: 0.16
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
No information available.
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 41 In case of fire and/or explosion do not breathe
fumes.
WGK (Water Danger/Protection)
CAS# 872-50-4: 1
United Kingdom Occupational Exposure Limits
CAS# 872-50-4: OES-United Kingdom, TWA 25 ppm TWA; 103 mg/m3 TWA
CAS# 872-50-4: OES-United Kingdom, STEL 75 ppm STEL; 309 mg/m3 STEL
Canada
CAS# 872-50-4 is listed on Canadas DSL List.
CAS# 872-50-4 is not listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 872-50-4: OEL-DENMARK:TWA 100 ppm (400 mg/m3)
OEL-GERMANY:TWA 100 ppm (400 mg/m3)
OEL-THE NETHERLANDS:TWA 100 ppm (400 mg/m3)
OEL-RUSSIA:STEL 100 mg/m3
OEL-SWITZERLAND:TWA 200 ppm (400 mg/m3)
OEL-UNITED KINGDOM:TWA 100 ppm (400 mg/m3)
US FEDERAL
TSCA
CAS# 872-50-4 is listed on the TSCA inventory.
