Name:
Nitrobenzene reagent ACS
Synonym:
Essence of mirbane; Mirbane oil; Nitrobenzol; Oil of mirbane; NTB
CAS:
98-95-3
Section 1 - Chemical Product
MSDS Name:Nitrobenzene reagent ACS
Synonym:Essence of mirbane; Mirbane oil; Nitrobenzol; Oil of mirbane; NTB
Synonym:Essence of mirbane; Mirbane oil; Nitrobenzol; Oil of mirbane; NTB
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 98-95-3 | Nitrobenzene | > 99.0 | 202-716-0 |
| Hazard Symbols: T N Risk Phrases: 23/24/25 40 48/23/24 62 51/53 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect. Toxic : danger of serious damage to health by prolonged exposure through inhalation and in contact with skin. Possible risk of impaired fertility. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.
Skin:
May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion:
May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death.
Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
Prolonged or repeated exposure may cause adverse reproductive effects. May cause liver and kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May cause fetal effects. May cause anemia and other blood cell abnormalities.
Repeated exposure may cause central nervous system damage. Repeated exposure may cause damage to the spleen.
Toxic by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect. Toxic : danger of serious damage to health by prolonged exposure through inhalation and in contact with skin. Possible risk of impaired fertility. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.
Skin:
May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion:
May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death.
Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
Prolonged or repeated exposure may cause adverse reproductive effects. May cause liver and kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May cause fetal effects. May cause anemia and other blood cell abnormalities.
Repeated exposure may cause central nervous system damage. Repeated exposure may cause damage to the spleen.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. A vapor suppressing foam may be used to reduce vapors.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 98-95-3: United Kingdom, WEL - TWA: 1 ppm TWA; 5.1 mg/m3 TWA United Kingdom, WEL - STEL: 2 ppm STEL; 10 mg/m3 STEL United States OSHA: 1 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 1 ppm VLE; 5 mg/m3 VLE France - VME: 1 ppm VME; 5 mg/m3 VME Germany: 1 ppm TWA; 5 mg/m3 TWA Germany: Skin absorber Japan: 1 ppm OEL; 5 mg/m3 OEL Malaysia: 1 ppm TWA; 5 mg/m3 TWA Netherlands: 1 ppm MAC; 5 mg/m3 MAC Russia: 3 mg/m3 TWA Spain: 1 ppm VLA-ED; 5 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 98-95-3: United Kingdom, WEL - TWA: 1 ppm TWA; 5.1 mg/m3 TWA United Kingdom, WEL - STEL: 2 ppm STEL; 10 mg/m3 STEL United States OSHA: 1 ppm TWA; 5 mg/m3 TWA Belgium - TWA: 1 ppm VLE; 5 mg/m3 VLE France - VME: 1 ppm VME; 5 mg/m3 VME Germany: 1 ppm TWA; 5 mg/m3 TWA Germany: Skin absorber Japan: 1 ppm OEL; 5 mg/m3 OEL Malaysia: 1 ppm TWA; 5 mg/m3 TWA Netherlands: 1 ppm MAC; 5 mg/m3 MAC Russia: 3 mg/m3 TWA Spain: 1 ppm VLA-ED; 5 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless to pale yellow
Odor: almond-like
pH: Not available.
Vapor Pressure: < 1 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 210 - 211 deg C @ 760mmHg
Freezing/Melting Point: 5 - 6 deg C
Autoignition Temperature: 496 deg C ( 924.80 deg F)
Flash Point: 87 deg C ( 188.60 deg F)
Explosion Limits, lower: 1.8%
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density: 1.2 g/cm3
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Substance can dangerously react with nitric acid, phenol, aluminum chloride, aniline, glycerine, silver perchlorate, dinitrogen tetroxide, caustics, tin, and zinc.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Substance can dangerously react with nitric acid, phenol, aluminum chloride, aniline, glycerine, silver perchlorate, dinitrogen tetroxide, caustics, tin, and zinc.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 98-95-3: DA6475000 LD50/LC50:
CAS# 98-95-3: Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 556 ppm/4H; Oral, mouse: LD50 = 590 mg/kg; Oral, rat: LD50 = 349 mg/kg; Skin, rat: LD50 = 2100 mg/kg.
Oral human LDLo: 35 mg/kg.
Carcinogenicity:
Nitrobenzene - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 8/26/97 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.
CAS# 98-95-3: DA6475000 LD50/LC50:
CAS# 98-95-3: Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 556 ppm/4H; Oral, mouse: LD50 = 590 mg/kg; Oral, rat: LD50 = 349 mg/kg; Skin, rat: LD50 = 2100 mg/kg.
Oral human LDLo: 35 mg/kg.
Carcinogenicity:
Nitrobenzene - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 8/26/97 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Zebrafish: LC50 = 112.5mg/L/96H Minnow (distilled water): LC50 = 20-24mg/L/6H Water flea: LC50 = 62mg/L/24H, 27mg/L/48H
Zebrafish: LC50 = 112.5mg/L/96H Minnow (distilled water): LC50 = 20-24mg/L/6H Water flea: LC50 = 62mg/L/24H, 27mg/L/48H
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing Group: II
IMO
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing Group: II
RID/ADR
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing group: II
USA RQ: CAS# 98-95-3: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 40 Limited evidence of a carcinogenic effect.
R 48/23/24 Toxic : danger of serious damage to
health by prolonged exposure through inhalation and in
contact with skin.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 62 Possible risk of impaired fertility.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 98-95-3: 2
Canada
CAS# 98-95-3 is listed on Canadas DSL List.
CAS# 98-95-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 98-95-3 is listed on the TSCA inventory.
