Name:
Nicotine (pract) 95% (gc)
Synonym:
S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine
CAS:
54-11-5
Section 1 - Chemical Product
MSDS Name:Nicotine (pract) 95% (gc)
Synonym:S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine
Synonym:S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 54-11-5 | Nicotine | 200-193-3 |
| Hazard Symbols: T+ Risk Phrases: 25 27 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic if swallowed. Very toxic in contact with skin.Hygroscopic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be fatal if absorbed through the skin.
Ingestion:
May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death.
Exposure causes initial nervous system stimulation followed by severe CNS depression. May cause ataxia and incoordination.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
May cause digestive tract and cardiac disturbances.
Toxic if swallowed. Very toxic in contact with skin.Hygroscopic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be fatal if absorbed through the skin.
Ingestion:
May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death.
Exposure causes initial nervous system stimulation followed by severe CNS depression. May cause ataxia and incoordination.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
May cause digestive tract and cardiac disturbances.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
Antidote: No specific antidote exists.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
Antidote: No specific antidote exists.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing.
Autoignition Temperature: 240 deg C ( 464.00 deg F) Flash Point: 101 deg C ( 213.80 deg F) NFPA Rating: health-4; flammability-1; reactivity-0 Explosion Limits, Lower: .70 vol % Upper: 4.00 vol %
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing.
Autoignition Temperature: 240 deg C ( 464.00 deg F) Flash Point: 101 deg C ( 213.80 deg F) NFPA Rating: health-4; flammability-1; reactivity-0 Explosion Limits, Lower: .70 vol % Upper: 4.00 vol %
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale.
Storage:
Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale.
Storage:
Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear impervious gloves.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear impervious gloves.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: clear light yellow
Odor: Slight fish odor when warm.
pH: Not available.
Vapor Pressure: 1 mm Hg @ 61.8C
Vapor Density: 5.61 (air=1)
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: 247 deg C @ 760.00MM HG
Freezing/Melting Point: -80 deg C
Decomposition Temperature: Not available.
Solubility: IN WATER: MISCIBLE BELOW 60??C
Specific Gravity/Density: 1.0100g/cm3
Molecular Formula: C10H14N2
Molecular Weight: 162.23
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong acids, strong oxidizers.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong acids, strong oxidizers.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 54-11-5: QS5250000 LD50/LC50:
CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50 mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg.
Carcinogenicity:
Nicotine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 54-11-5: QS5250000 LD50/LC50:
CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50 mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg.
Carcinogenicity:
Nicotine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
CDG/CPL
IMO
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing Group: II
IATA
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing Group: II
RID/ADR
Shipping Name: NICOTINE
Dangerous Goods Code: 6.1(90B)
UN Number: 1654
Canadian TDG
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: UN1654
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 25 Toxic if swallowed.
R 27 Very toxic in contact with skin.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident of if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 54-11-5:
Canada
CAS# 54-11-5 is listed on Canadas DSL/NDSL List.
This product has a WHMIS classification of D1A, D2B.
CAS# 54-11-5 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 54-11-5:. OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin. OEL-AUS
TRALIA:TWA 0.5 mg/m3;Skin. OEL-BELGIUM:TWA 0.5 mg/m3;Skin. OEL-DENMARK
:TWA 0.5 mg/m3;Skin. OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin. OE
L-FRANCE:TWA 0.5 mg/m3;Skin. OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin
. OEL-HUNGARY:STEL 0.5 mg/m3;Skin. OEL-THE NETHERLANDS:TWA 0.07 ppm (0
.5 mg/m3);Skin. OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin. OEL-POLAND:TWA
0.5 mg/m3. OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.1 ppm;Skin
. OEL-THAILAND:TWA 0.5 mg/m3. OEL-TURKEY:TWA 0.5 mg/m3;Skin
D KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin. OEL IN BULGARIA, COLOMBIA
, JORDAN, KOREA check ACGIH TLV. OEL IN NEW ZEALAND, SINGAPORE, VIETNA
M check ACGI TLV
US FEDERAL
TSCA
CAS# 54-11-5 is listed on the TSCA inventory.
