Name:
Ninhydrin Solution
Synonym:
CAS:
71-36-3
Section 1 - Chemical Product
MSDS Name:Ninhydrin Solution
Synonym:
Synonym:
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 71-36-3 | N-butyl alcohol | 99.5 | 200-751-6 |
| Hazard Symbols: XN Risk Phrases: 10 22 37/38 41 67 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Harmful if swallowed. Irritating to respiratory system and skin. Risk of serious damage to eyes. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause corneal edema and inflammation. May cause lacrimation (tearing), blurred vision, and photophobia.
Skin:
Causes severe skin irritation. May be harmful if absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed. Aspiration may be fatal. May be absorbed from the gastrointestinal tract.
Inhalation:
Causes respiratory tract irritation. May cause cardiovascular disturbances, hearing abnormalities, central nervous system depression, muscle weakness, and possible death due to respiratory failure. May be absorbed through the lungs.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause liver, kidney, and heart damage. May cause damage to the auditory nerve (some hearing loss) and vestibular injury.
Flammable. Harmful if swallowed. Irritating to respiratory system and skin. Risk of serious damage to eyes. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause corneal edema and inflammation. May cause lacrimation (tearing), blurred vision, and photophobia.
Skin:
Causes severe skin irritation. May be harmful if absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed. Aspiration may be fatal. May be absorbed from the gastrointestinal tract.
Inhalation:
Causes respiratory tract irritation. May cause cardiovascular disturbances, hearing abnormalities, central nervous system depression, muscle weakness, and possible death due to respiratory failure. May be absorbed through the lungs.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause liver, kidney, and heart damage. May cause damage to the auditory nerve (some hearing loss) and vestibular injury.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Alcoholic beverage consumption may enhance the toxic effects of this substance. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product.
Butanol is especially toxic if aspirated. Treat symptomatically and supportively.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Alcoholic beverage consumption may enhance the toxic effects of this substance. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product.
Butanol is especially toxic if aspirated. Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame. Containers may explode when heated.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame. Containers may explode when heated.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame.
Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from explosives, organic peroxides, poisons, and radioactive materials.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame.
Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from explosives, organic peroxides, poisons, and radioactive materials.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 71-36-3: United Kingdom, WEL - STEL: 50 ppm STEL; 154 mg/m3 STEL United States OSHA: 100 ppm TWA; 300 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 154 mg/m3 VLE France - VLE: 50 ppm VLE; 150 mg/m3 VLE Germany: 100 ppm TWA; 310 mg/m3 TWA Japan: 50 ppm Ceiling; 150 mg/m3 Ceiling Malaysia: 50 ppm Ceiling; 152 mg/m3 Ceiling Netherlands: 15 ppm STEL; 45 mg/m3 STEL Russia: 10 mg/m3 TWA Spain: 50 ppm VLA-EC; 154 mg/m3 VLA-EC CAS# 485-47-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 71-36-3: United Kingdom, WEL - STEL: 50 ppm STEL; 154 mg/m3 STEL United States OSHA: 100 ppm TWA; 300 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 154 mg/m3 VLE France - VLE: 50 ppm VLE; 150 mg/m3 VLE Germany: 100 ppm TWA; 310 mg/m3 TWA Japan: 50 ppm Ceiling; 150 mg/m3 Ceiling Malaysia: 50 ppm Ceiling; 152 mg/m3 Ceiling Netherlands: 15 ppm STEL; 45 mg/m3 STEL Russia: 10 mg/m3 TWA Spain: 50 ppm VLA-EC; 154 mg/m3 VLA-EC CAS# 485-47-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: sweetish odor - putrid odor - fusel oil odor
pH: Not available.
Vapor Pressure: 6.5 mm Hg @ 25 deg C
Viscosity: 2.94 cP at 20 deg C
Boiling Point: 117.4 deg C
Freezing/Melting Point: -90 deg C
Autoignition Temperature: 343 deg C ( 649.40 deg F)
Flash Point: 37 deg C ( 98.60 deg F)
Explosion Limits, lower: 1.4 vol %
Explosion Limits, upper: 11.2 vol %
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 0.810 (Water=1)
Molecular Formula: CH3(CH2)2CH2OH
Molecular Weight: 74.0694
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acid chlorides, alkali metals, aluminum, copper, copper alloys, halogens, organic peroxides, acid anhydrides, chromium trioxide, mineral acids.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acid chlorides, alkali metals, aluminum, copper, copper alloys, halogens, organic peroxides, acid anhydrides, chromium trioxide, mineral acids.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 71-36-3: EO1400000 CAS# 485-47-2: NK5425000 LD50/LC50:
CAS# 71-36-3: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 405 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rat: LC50 = 8000 ppm/4H; Inhalation, rat: LC50 = 24000 mg/m3/4H; Oral, mouse: LD50 = 100 mg/kg; Oral, rabbit: LD50 = 3484 mg/kg; Oral, rabbit: LD50 = 3400 mg/kg; Oral, rat: LD50 = 790 mg/kg; Oral, rat: LD50 = 800 mg/kg; Skin, rabbit: LD50 = 3400 mg/kg.
CAS# 485-47-2.
Carcinogenicity:
N-butyl alcohol - Not listed by ACGIH, IARC, or NTP.
Ninhydrin Solution - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 71-36-3: EO1400000 CAS# 485-47-2: NK5425000 LD50/LC50:
CAS# 71-36-3: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 405 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rat: LC50 = 8000 ppm/4H; Inhalation, rat: LC50 = 24000 mg/m3/4H; Oral, mouse: LD50 = 100 mg/kg; Oral, rabbit: LD50 = 3484 mg/kg; Oral, rabbit: LD50 = 3400 mg/kg; Oral, rat: LD50 = 790 mg/kg; Oral, rat: LD50 = 800 mg/kg; Skin, rabbit: LD50 = 3400 mg/kg.
CAS# 485-47-2.
Carcinogenicity:
N-butyl alcohol - Not listed by ACGIH, IARC, or NTP.
Ninhydrin Solution - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 1510-1730 mg/L; 96 Hr; Static bioassay at 24.7C (pH 7.64)Water flea Daphnia: EC50 = 1980-1983 mg/L; 48 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 2817-3710 mg/L; 5,30 min; Microtox testRelease of n-butanol to soil may result in volatilization from the soil surface and biodegradation is expected to be significant. n-Butanol should not bind strongly to soil and so is expected to leach into groundwater. Release of n-butanol to water is expected to result in biodegradation and in volatilization from the water surface. Photooxidation by hydroxyl radicals is expected to be slow.
Fish: Fathead Minnow: LC50 = 1510-1730 mg/L; 96 Hr; Static bioassay at 24.7C (pH 7.64)Water flea Daphnia: EC50 = 1980-1983 mg/L; 48 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 2817-3710 mg/L; 5,30 min; Microtox testRelease of n-butanol to soil may result in volatilization from the soil surface and biodegradation is expected to be significant. n-Butanol should not bind strongly to soil and so is expected to leach into groundwater. Release of n-butanol to water is expected to result in biodegradation and in volatilization from the water surface. Photooxidation by hydroxyl radicals is expected to be slow.
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: BUTANOL, SOLUTION
Hazard Class: 3
UN Number: 1120
Packing Group: III
IMO
Shipping Name: BUTANOL, SOLUTION
Hazard Class: 3
UN Number: 1120
Packing Group: III
RID/ADR
Shipping Name: BUTANOL, SOLUTION
Hazard Class: 3
UN Number: 1120
Packing group: III
USA RQ: CAS# 71-36-3: 5000 lb final RQ; 2270 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 22 Harmful if swallowed.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 7/9 Keep container tightly closed and in a
well-ventilated place.
S 13 Keep away from food, drink and animal feeding
stuffs.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 71-36-3: 1
CAS# 485-47-2: 2
Canada
CAS# 71-36-3 is listed on Canadas DSL List.
CAS# 485-47-2 is listed on Canadas DSL List.
CAS# 71-36-3 is listed on Canadas Ingredient Disclosure List.
CAS# 485-47-2 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 71-36-3 is listed on the TSCA inventory.
CAS# 485-47-2 is listed on the TSCA inventory.
