Name:
o-Toluidine
Synonym:
2-Aminotoluene; 2-Methylaniline; 2-Methylbenzenamine; ortho-Methylaniline; 1-Amino-2-Methylbenzene; 1-Methyl-2-Aminobenzene
CAS:
95-53-4
Section 1 - Chemical Product
MSDS Name:o-Toluidine
Synonym:2-Aminotoluene; 2-Methylaniline; 2-Methylbenzenamine; ortho-Methylaniline; 1-Amino-2-Methylbenzene; 1-Methyl-2-Aminobenzene
Synonym:2-Aminotoluene; 2-Methylaniline; 2-Methylbenzenamine; ortho-Methylaniline; 1-Amino-2-Methylbenzene; 1-Methyl-2-Aminobenzene
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 95-53-4 |
| Hazard Symbols: T N Risk Phrases: |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Irritating to eyes. May cause cancer. Very toxic to aquatic organisms.Light sensitive.Air sensitive.Cancer suspect agent.Dangerous for the environment.
Potential Health Effects
Eye:
Causes severe eye irritation. May result in corneal injury.
Skin:
Causes skin irritation. May be absorbed through the skin. Causes symptoms similar to those of inhalation. May cause dermatitis.
Excessive drying of the skin may result from repeated or prolonged contact.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause effects similar to those for inhalation exposure.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May cause anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Exposure produces central nervous system depression. May cause kidney damage. May cause headache and cyanosis of the lips, mucous membranes and fingernail beds and the tongue. Clinical signs of intoxication with o-toluidine in humans have included methemoglobinemia, hematuria, marked renal & bladder irritation, & physiological & psychological disturbances.
o-Toluidine has been absorbed via the respiratory tract & skin.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. May cause kidney injury. May cause cancer according to animal studies. Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). This substance has caused adverse reproductive and fetal effects in laboratory animals. The chronic (long-term) effects in workers exposed to o-toluidine include anemia, anorexia, weight loss, skin lesions, central nervous system depression, cyanosis, and methemoglobinemia.
Toxic by inhalation and if swallowed. Irritating to eyes. May cause cancer. Very toxic to aquatic organisms.Light sensitive.Air sensitive.Cancer suspect agent.Dangerous for the environment.
Potential Health Effects
Eye:
Causes severe eye irritation. May result in corneal injury.
Skin:
Causes skin irritation. May be absorbed through the skin. Causes symptoms similar to those of inhalation. May cause dermatitis.
Excessive drying of the skin may result from repeated or prolonged contact.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause effects similar to those for inhalation exposure.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May cause anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Exposure produces central nervous system depression. May cause kidney damage. May cause headache and cyanosis of the lips, mucous membranes and fingernail beds and the tongue. Clinical signs of intoxication with o-toluidine in humans have included methemoglobinemia, hematuria, marked renal & bladder irritation, & physiological & psychological disturbances.
o-Toluidine has been absorbed via the respiratory tract & skin.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. May cause kidney injury. May cause cancer according to animal studies. Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). This substance has caused adverse reproductive and fetal effects in laboratory animals. The chronic (long-term) effects in workers exposed to o-toluidine include anemia, anorexia, weight loss, skin lesions, central nervous system depression, cyanosis, and methemoglobinemia.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. Cleansing of the entire contaminated area of the body is of utmost importance.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. Cleansing of the entire contaminated area of the body is of utmost importance.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. Approach spill from upwind.
Use water spray to cool and disperse vapors and protect personnel.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. Approach spill from upwind.
Use water spray to cool and disperse vapors and protect personnel.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Avoid contact with air and sunlight. Use only with adequate ventilation. Keep away from heat and flame.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Do not store in direct sunlight. Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light and air. Material darkens on exposure to air. Separate from oxidizing materials.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Avoid contact with air and sunlight. Use only with adequate ventilation. Keep away from heat and flame.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Do not store in direct sunlight. Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light and air. Material darkens on exposure to air. Separate from oxidizing materials.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: clear slightly yellow
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.26 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 200 deg C
Freezing/Melting Point: -16 deg C
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Flash Point: 85 deg C ( 185.00 deg F)
Explosion Limits, lower: 1.50 vol %
Explosion Limits, upper: Not available.
Decomposition Temperature: >200 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.0000 g/cm3
Molecular Formula: C7H9N
Molecular Weight: 107.15
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Conditions to Avoid:
Light, exposure to air, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, nitric acid.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Conditions to Avoid:
Light, exposure to air, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, nitric acid.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 95-53-4: XU2975000 LD50/LC50:
Not available.
Carcinogenicity:
o-Toluidine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 95-53-4: XU2975000 LD50/LC50:
Not available.
Carcinogenicity:
o-Toluidine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Bacteria: Phytobacterium phosphoreum: EC50 = 13.2 mg/L; 30 min; Microtox testIf released on land, o-toluidine will be lost by a combination of biodegradation, oxidation, and chemical binding to soil components. If released into water, it will also be primarily lost by biodegradation, oxidation and photooxidation. There will also be some adsorption to sediment. Bioconcentration in fish should not be an important fate process. In the atmosphere, o-toluidine will photodegrade (estimated half-life 2.4 hr).
Bacteria: Phytobacterium phosphoreum: EC50 = 13.2 mg/L; 30 min; Microtox testIf released on land, o-toluidine will be lost by a combination of biodegradation, oxidation, and chemical binding to soil components. If released into water, it will also be primarily lost by biodegradation, oxidation and photooxidation. There will also be some adsorption to sediment. Bioconcentration in fish should not be an important fate process. In the atmosphere, o-toluidine will photodegrade (estimated half-life 2.4 hr).
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
IMO
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
RID/ADR
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing group: II
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 36 Irritating to eyes.
R 45 May cause cancer.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 95-53-4: 3
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 95-53-4 is not listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 95-53-4: OEL-AUSTRALIA:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-BELGIUM:TWA 2 ppm (8.8 mg/m3);Skin;Carcinogen
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9
OEL-DENMARK:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;CAR
OEL-FRANCE:TWA 2 ppm (9 mg/m3);Carcinogen
OEL-FRANCE;CAR (salts)
OEL-GERMANY;Skin;Carcinogen
OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin
OEL-POLAND:TWA 3 mg/m3
OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1 mg/m3;Skin;Carcinogen
OEL-SWEDEN;Carcinogen
OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 2 ppm (9 mg/m3);STEL 5 ppm (22 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 95-53-4 is not listed on the TSCA inventory.
It is for research and development use only.
