Name:
Oxidising Solution - Expedite
Synonym:
0.02M Iodine in THF / Pyridine / Water
CAS:
109-99-9
Section 1 - Chemical Product
MSDS Name:Oxidising Solution - Expedite
Synonym:0.02M Iodine in THF / Pyridine / Water
Synonym:0.02M Iodine in THF / Pyridine / Water
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 109-99-9 | Tetrahydrofuran | 89-91 | 203-726-8 |
| Hazard Symbols: XI F Risk Phrases: 11 19 36/37 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. May form explosive peroxides. Irritating to eyes and respiratory system.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of inhalation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Vapors may cause dizziness or suffocation. Inhalation may cause coughing, difficulty breathing and loss of consciousness.
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. May cause lung damage. Narcotic in high concentrations.
Highly flammable. May form explosive peroxides. Irritating to eyes and respiratory system.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of inhalation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Vapors may cause dizziness or suffocation. Inhalation may cause coughing, difficulty breathing and loss of consciousness.
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. May cause lung damage. Narcotic in high concentrations.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid and vapor. Forms peroxides of unknown stability. Containers may explode in the heat of a fire. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas. Will be easily ignited by heat, sparks or flame.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid and vapor. Forms peroxides of unknown stability. Containers may explode in the heat of a fire. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas. Will be easily ignited by heat, sparks or flame.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Isolate area and deny entry. A vapor suppressing foam may be used to reduce vapors.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Isolate area and deny entry. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Prevent build up of vapors to explosive concentration. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool place in the original container and protect from sunlight. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Flammables-area. Regularly check inhibitor levels to maintain peroxide levels below 1%. Store protected from moisture.
Wash thoroughly after handling. Use only in a well-ventilated area.
Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Prevent build up of vapors to explosive concentration. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool place in the original container and protect from sunlight. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Flammables-area. Regularly check inhibitor levels to maintain peroxide levels below 1%. Store protected from moisture.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 109-99-9: United Kingdom, WEL - TWA: 50 ppm TWA; 150 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 300 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 599 mg/m3 VLE Belgium - STEL: 100 ppm VLE; 300 mg/m3 VLE France - VME: 200 ppm VME; 590 mg/m3 VME Germany: 50 ppm TWA; 150 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 100 ppm MAC; 300 mg/m3 MAC Russia: 100 mg/m3 TWA Spain: 50 ppm VLA-ED; 150 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 300 mg/m3 VLA-EC CAS# 110-86-1: United Kingdom, WEL - TWA: 5 ppm TWA; 16 mg/m3 TWA United Kingdom, WEL - STEL: 10 ppm STEL; 33 mg/m3 STEL United States OSHA: 5 ppm TWA; 15 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 16 mg/m3 VLE France - VME: 5 ppm VME; 15 mg/m3 VME France - VLE: 10 ppm VLE; 30 mg/m3 VLE Germany: 5 ppm TWA; 16 mg/m3 TWA Germany: Skin absorber Malaysia: 5 ppm TWA; 16 mg/m3 TWA Netherlands: 0.3 ppm MAC; 0.9 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 15 mg/m3 VLA-ED CAS# 7553-56-2: United Kingdom, WEL - STEL: 0.1 ppm STEL; 1.1 mg/m3 STEL United States OSHA: ; 0.1 ppm Ceiling; 1 mg/m3 Ceiling Belgium - TWA: 0.1 ppm VLE; 1 mg/m3 VLE France - VLE: 0.1 ppm VLE; 1 mg/m3 VLE Germany: 0.1 ppm TWA; 1.1 mg/m3 TWA Germany: Skin absorber Japan: 0.1 ppm OEL; 1 mg/m3 OEL Malaysia: 0.1 ppm Ceiling; 1.0 mg/m3 Ceiling Russia: 1 mg/m3 TWA Spain: 0.1 ppm VLA-EC; 1 mg/m3 VLA-EC CAS# 7732-18-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 109-99-9: United Kingdom, WEL - TWA: 50 ppm TWA; 150 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 300 mg/m3 STEL United States OSHA: 200 ppm TWA; 590 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 599 mg/m3 VLE Belgium - STEL: 100 ppm VLE; 300 mg/m3 VLE France - VME: 200 ppm VME; 590 mg/m3 VME Germany: 50 ppm TWA; 150 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 590 mg/m3 OEL Malaysia: 200 ppm TWA; 590 mg/m3 TWA Netherlands: 100 ppm MAC; 300 mg/m3 MAC Russia: 100 mg/m3 TWA Spain: 50 ppm VLA-ED; 150 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 300 mg/m3 VLA-EC CAS# 110-86-1: United Kingdom, WEL - TWA: 5 ppm TWA; 16 mg/m3 TWA United Kingdom, WEL - STEL: 10 ppm STEL; 33 mg/m3 STEL United States OSHA: 5 ppm TWA; 15 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 16 mg/m3 VLE France - VME: 5 ppm VME; 15 mg/m3 VME France - VLE: 10 ppm VLE; 30 mg/m3 VLE Germany: 5 ppm TWA; 16 mg/m3 TWA Germany: Skin absorber Malaysia: 5 ppm TWA; 16 mg/m3 TWA Netherlands: 0.3 ppm MAC; 0.9 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 15 mg/m3 VLA-ED CAS# 7553-56-2: United Kingdom, WEL - STEL: 0.1 ppm STEL; 1.1 mg/m3 STEL United States OSHA: ; 0.1 ppm Ceiling; 1 mg/m3 Ceiling Belgium - TWA: 0.1 ppm VLE; 1 mg/m3 VLE France - VLE: 0.1 ppm VLE; 1 mg/m3 VLE Germany: 0.1 ppm TWA; 1.1 mg/m3 TWA Germany: Skin absorber Japan: 0.1 ppm OEL; 1 mg/m3 OEL Malaysia: 0.1 ppm Ceiling; 1.0 mg/m3 Ceiling Russia: 1 mg/m3 TWA Spain: 0.1 ppm VLA-EC; 1 mg/m3 VLA-EC CAS# 7732-18-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: liquid
Color: colorless
Odor: ethereal odor - fruity odor
pH: Not available.
Vapor Pressure: 160 mm Hg @25C
Viscosity: 0.48 cP @ 20C
Boiling Point: 65.4 deg C
Freezing/Melting Point: -65 deg C
Autoignition Temperature: 321 deg C ( 609.80 deg F)
Flash Point: -14 deg C ( 6.80 deg F)
Explosion Limits, lower: 1.8 vol %
Explosion Limits, upper: 11.8 vol %
Decomposition Temperature: Not available.
Solubility in water: Miscible.
Specific Gravity/Density: 0.89
Molecular Formula: C4H8O
Molecular Weight: 72.0554
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Prolonged exposure to air and sunlight may form unstable peroxides.
Explosive peroxides may form on concentration. Peroxides can be detonated by friction, impact, or heating. Peroxide formation may occur in containers that have been opened and remain in storage.
Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability.
Conditions to Avoid:
Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability., incompatible materials, light, ignition sources, moisture, acids, excess heat.
Incompatibilities with Other Materials:
Acids, bases, oxidizing agents, oxygen, sodium aluminum hydride, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), sodium tetrahydroaluminate, 2-aminophenol + potassium dioxide, lithium tetrahydroaluminate, borane, metal halides, bromine, calcium hydride + heat, 2-aminophenol, moisture.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: May occur.
Prolonged exposure to air and sunlight may form unstable peroxides.
Explosive peroxides may form on concentration. Peroxides can be detonated by friction, impact, or heating. Peroxide formation may occur in containers that have been opened and remain in storage.
Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability.
Conditions to Avoid:
Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability., incompatible materials, light, ignition sources, moisture, acids, excess heat.
Incompatibilities with Other Materials:
Acids, bases, oxidizing agents, oxygen, sodium aluminum hydride, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), sodium tetrahydroaluminate, 2-aminophenol + potassium dioxide, lithium tetrahydroaluminate, borane, metal halides, bromine, calcium hydride + heat, 2-aminophenol, moisture.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: May occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 109-99-9: LU5950000 CAS# 110-86-1: UR8400000 CAS# 7553-56-2: NN1575000 CAS# 7732-18-5: ZC0110000 LD50/LC50:
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg.
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
CAS# 7553-56-2: Oral, mouse: LD50 = 22 gm/kg; Oral, mouse: LD50 = 1000 mg/kg; Oral, rabbit: LD50 = 10 gm/kg; Oral, rat: LD50 = 14 gm/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
Carcinogenicity:
Tetrahydrofuran - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to Pyridine - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 5/17/02 Iodine - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 109-99-9: LU5950000 CAS# 110-86-1: UR8400000 CAS# 7553-56-2: NN1575000 CAS# 7732-18-5: ZC0110000 LD50/LC50:
CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg.
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
CAS# 7553-56-2: Oral, mouse: LD50 = 22 gm/kg; Oral, mouse: LD50 = 1000 mg/kg; Oral, rabbit: LD50 = 10 gm/kg; Oral, rat: LD50 = 14 gm/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
Carcinogenicity:
Tetrahydrofuran - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to Pyridine - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 5/17/02 Iodine - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay (pH 7.5)Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values. This compound should volatilize from water surfaces. An estimated BCF value of 1 suggests that tetrahydrofuran will not bioconcentrate in aquatic organisms.
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay (pH 7.5)Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values. This compound should volatilize from water surfaces. An estimated BCF value of 1 suggests that tetrahydrofuran will not bioconcentrate in aquatic organisms.
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing Group: II
IMO
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing Group: II
RID/ADR
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3
UN Number: 1993
Packing group: II
USA RQ: CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
USA RQ: CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI F
Risk Phrases:
R 11 Highly flammable.
R 19 May form explosive peroxides.
R 36/37 Irritating to eyes and respiratory system.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static
discharges.
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
CAS# 110-86-1: 2
CAS# 7553-56-2: 1
CAS# 7732-18-5: No information available.
Canada
CAS# 109-99-9 is listed on Canadas DSL List.
CAS# 110-86-1 is listed on Canadas DSL List.
CAS# 7553-56-2 is listed on Canadas DSL List.
CAS# 7732-18-5 is listed on Canadas DSL List.
CAS# 109-99-9 is listed on Canadas Ingredient Disclosure List.
CAS# 110-86-1 is listed on Canadas Ingredient Disclosure List.
CAS# 7553-56-2 is listed on Canadas Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 109-99-9 is listed on the TSCA inventory.
CAS# 110-86-1 is listed on the TSCA inventory.
CAS# 7553-56-2 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
