Name:
P-Anisidine 99%
Synonym:
p-Aminoanisole; 4-Aminoanisole; 4-Anisidine; p-Methoxyanilin
CAS:
104-94-9
Section 1 - Chemical Product
MSDS Name:P-Anisidine 99%
Synonym:p-Aminoanisole; 4-Aminoanisole; 4-Anisidine; p-Methoxyanilin
Synonym:p-Aminoanisole; 4-Aminoanisole; 4-Anisidine; p-Methoxyanilin
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 104-94-9 | p-Anisidine | 99.0 | 203-254-2 |
| Hazard Symbols: T+ N Risk Phrases: 26/27/28 33 50 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion. Effects of contact may be delayed.
May cause contact dermatitis.
Ingestion:
May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed.
Inhalation:
May cause severe allergic respiratory reaction. May cause respiratory tract irritation. Effects of inhalation may be delayed.
Chronic:
May cause cancer according to animal studies.
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion. Effects of contact may be delayed.
May cause contact dermatitis.
Ingestion:
May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed.
Inhalation:
May cause severe allergic respiratory reaction. May cause respiratory tract irritation. Effects of inhalation may be delayed.
Chronic:
May cause cancer according to animal studies.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Antidote: None reported.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Antidote: None reported.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May polymerize explosively when involved in a fire.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May polymerize explosively when involved in a fire.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149.
Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149.
Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Appearance: beige
Odor: amine-like
pH: Not available.
Vapor Pressure: .0006 mm Hg @ 25 C
Viscosity: Not available.
Boiling Point: 240 - 243 deg C @ 760.00mm Hg
Freezing/Melting Point: 58 deg C
Autoignition Temperature: 515 deg C ( 959.00 deg F)
Flash Point: 122 deg C ( 251.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >300 deg C
Solubility in water: Soluble in hot water.
Specific Gravity/Density: 1.0700g/cm3
Molecular Formula: C7H9NO
Molecular Weight: 123.15
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: May occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: May occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 104-94-9: BZ5450000 LD50/LC50:
CAS# 104-94-9: Oral, mouse: LD50 = 1410 mg/kg; Oral, rabbit: LD50 = 2900 mg/kg; Oral, rat: LD50 = 1320 mg/kg; Skin, rat: LD50 = 3200 mg/kg.
Carcinogenicity:
p-Anisidine - ACGIH: A4 - Not Classifiable as a Human Carcinogen IARC: Group 3 carcinogen See actual entry in RTECS for complete information.
CAS# 104-94-9: BZ5450000 LD50/LC50:
CAS# 104-94-9: Oral, mouse: LD50 = 1410 mg/kg; Oral, rabbit: LD50 = 2900 mg/kg; Oral, rat: LD50 = 1320 mg/kg; Skin, rat: LD50 = 3200 mg/kg.
Carcinogenicity:
p-Anisidine - ACGIH: A4 - Not Classifiable as a Human Carcinogen IARC: Group 3 carcinogen See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Water flea EC50 = 0.18 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 14.5 mg/L; 30 Minutes; Microtox test, 15 degrees C
Water flea EC50 = 0.18 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 14.5 mg/L; 30 Minutes; Microtox test, 15 degrees C
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: ANISIDINES, SOLID
Hazard Class: 6.1
UN Number: 2431
Packing Group: III
IMO
Shipping Name: ortho-ANISIDINE
Hazard Class: 6.1
UN Number: 2431
Packing Group: III
RID/ADR
Shipping Name: ANISIDINES, SOLID
Dangerous Goods Code: 6.1(12C)
UN Number: 2431
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 104-94-9: 2
United Kingdom Occupational Exposure Limits
CAS# 104-94-9: OES-United Kingdom, TWA 0.1 ppm TWA; 0.51 mg/m3 TWA
Canada
CAS# 104-94-9 is listed on Canadas DSL List.
CAS# 104-94-9 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 104-94-9: OEL-AUSTRALIA:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-AUSTRIA:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-BELGIUM:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-DENMARK:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin;CAR
OEL-FRANCE:TWA 0.1 ppm (0.5 mg/m3);Skin;Carcinoge
OEL-GERMANY:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-INDIA:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin
OEL-RUSSIA:STEL 1 mg/m3;Skin
OEL-SWITZERLAND:TWA 0.1 ppm (0.5 mg/m3);STEL 0.2 ppm;Skin
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.5 mg/m3);Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 104-94-9 is listed on the TSCA inventory.
