Name:
p-Nitrophenol
Synonym:
4-Hydroxynitrobenzene; 4-Nitrophenol
CAS:
100-02-7
Section 1 - Chemical Product
MSDS Name:p-Nitrophenol
Synonym:4-Hydroxynitrobenzene; 4-Nitrophenol
Synonym:4-Hydroxynitrobenzene; 4-Nitrophenol
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 100-02-7 | p-Nitrophenol | 98% | 202-811-7 |
| Hazard Symbols: XN Risk Phrases: 20/21/22 33 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Danger of cumulative effects.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Causes severe skin irritation. If absorbed, causes symptoms similar to those of ingestion.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). Ingestion may produce shock, collapse, and convulsions.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
Harmful by inhalation, in contact with skin and if swallowed. Danger of cumulative effects.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Causes severe skin irritation. If absorbed, causes symptoms similar to those of ingestion.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). Ingestion may produce shock, collapse, and convulsions.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Combustion generates toxic fumes. Containers may explode in the heat of a fire. Combustible material; even though it may take some effort to ignite.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Combustion generates toxic fumes. Containers may explode in the heat of a fire. Combustible material; even though it may take some effort to ignite.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep away from food and drinking water. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep away from food and drinking water. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Appearance: yellow
Odor: odorless
pH: Not available.
Vapor Pressure: .6 mm Hg @ 120 deg
Viscosity: Not available.
Boiling Point: 534 deg F
Freezing/Melting Point: 113.4 deg C
Autoignition Temperature: 541 deg F ( 282.78 deg C)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 1.479 - 1.495
Molecular Formula: C6H5NO3
Molecular Weight: 139.0399
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, temperatures above 125C.
Incompatibilities with Other Materials:
Strong oxidizing agents; Strong bases; Diethyl phosphite Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable.
Conditions to Avoid:
Incompatible materials, temperatures above 125C.
Incompatibilities with Other Materials:
Strong oxidizing agents; Strong bases; Diethyl phosphite Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 100-02-7: SM2275000 LD50/LC50:
CAS# 100-02-7: Dermal, guinea pig: LD50 = >1 gm/kg; Oral, mouse: LD50 = 282 mg/kg; Oral, rat: LD50 = 202 mg/kg; Skin, rat: LD50 = 1024 mg/kg.
Carcinogenicity:
p-Nitrophenol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 100-02-7: SM2275000 LD50/LC50:
CAS# 100-02-7: Dermal, guinea pig: LD50 = >1 gm/kg; Oral, mouse: LD50 = 282 mg/kg; Oral, rat: LD50 = 202 mg/kg; Skin, rat: LD50 = 1024 mg/kg.
Carcinogenicity:
p-Nitrophenol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: p-NITROPHENOL
Hazard Class: 6.1
UN Number: 1663
Packing Group:
IMO
Shipping Name: p-NITROPHENOL
Hazard Class: 6.1
UN Number: 1663
Packing Group:
RID/ADR
Shipping Name: p-NITROPHENOL
Dangerous Goods Code: 6.1(12C)
UN Number: 1663
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
WGK (Water Danger/Protection)
CAS# 100-02-7: 2
United Kingdom Occupational Exposure Limits
Canada
CAS# 100-02-7 is listed on Canadas DSL List.
CAS# 100-02-7 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 100-02-7: Not available.
US FEDERAL
TSCA
CAS# 100-02-7 is listed on the TSCA inventory.
