MSDS Name:Phenol/Chloroform/Isoamyl Alcohol (pH5.2)
Synonym:Phenol Chloroform Mixture II (25:24:1

EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Causes burns. Harmful : danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.Possible risk of irreversible effects.Corrosive.Mutagen.
Potential Health Effects
Eye:
Causes eye irritation and possible burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Overexposure may cause methemoglobinemia. May cause systemic effects.
Causes digestive tract irritation with possible burns.
Inhalation:
May be fatal if exposed to high concentrations. May cause severe respiratory tract irritation and possible burns. Aspiration may lead to pulmonary edema. May also cause pallor, loss of appetite, nausea, vomiting, diarrhea, weakness, darkened urine, headache, sweating, convulsions, cyanosis (bluish skin due to deficient oxygenation of the blood), unconsciousness, fatigue, pulmonary edema & coma. May cause systemic effects. Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
May cause liver and kidney damage. May cause fetal effects. Effects may be delayed. Repeated skin contact may cause dermatitis with dark pigmentation of the skin. Chronic exposure has been associated with an increased incidence of kidney, liver, rectal, bladder, colon, brain, and lymph node cancer.

Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. SPEEDY ACTION IS CRITICAL! Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Persons with liver or kidney disease should not be exposed to phenol for any length of time.
Antidote: Activated charcoal, followed by cathartic, may be preferred to ipecac induced emesis or lavage in decontamination of the GI tract and preventing systemic absorption of phenol.

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Do NOT get water inside containers. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Keep refrigerated. (Store below 4C/39F.)

Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 67-66-3: United Kingdom, WEL - TWA: 2 ppm TWA; 9.9 mg/m3 TWA United Kingdom, WEL - STEL: 6 ppm STEL; 29.7 mg/m3 STEL United States OSHA: ; 50 ppm Ceiling; 240 mg/m3 Ceiling Belgium - TWA: 10 ppm VLE; 50 mg/m3 VLE France - VME: 5 ppm VME; 25 mg/m3 VME France - VLE: 50 ppm VLE; 250 mg/m3 VLE Germany: 4 ppm TWA (large technical manufacture and use); 20 mg/m TWA (large technical m Germany: Skin absorber Japan: 10 ppm OEL; 49 mg/m3 OEL Malaysia: 10 ppm TWA; 49 mg/m3 TWA Netherlands: 5 ppm STEL; 25 mg/m3 STEL Netherlands: 1 ppm MAC; 5 mg/m3 MAC Spain: 2 ppm VLA-ED; 10 mg/m3 VLA-ED CAS# 108-95-2: United Kingdom, WEL - TWA: 2 ppm TWA United Kingdom, WEL - STEL: 6 ppm STEL United States OSHA: 5 ppm TWA; 19 mg/m3 TWA Belgium - TWA: 2 ppm VLE; 7.8 mg/m3 VLE France - VME: 5 ppm VME; 19 mg/m3 VME Germany: 5 ppm TWA; 19 mg/m3 TWA Germany: Skin absorber Japan: 5 ppm OEL; 19 mg/m3 OEL Malaysia: 5 ppm TWA; 15 mg/m3 TWA Netherlands: 2 ppm MAC; 8 mg/m3 MAC Russia: 0.3 mg/m3 TWA Spain: 2 ppm VLA-ED; 8 mg/m3 VLA-ED CAS# 123-51-3: United Kingdom, WEL - TWA: 100 ppm TWA; 366 mg/m3 TWA United Kingdom, WEL - STEL: 125 ppm STEL; 458 mg/m3 STEL United States OSHA: 100 ppm TWA; 360 mg/m3 TWA Belgium - TWA: 100 ppm VLE; 366 mg/m3 VLE Belgium - STEL: 125 ppm VLE; 459 mg/m3 VLE France - VME: 100 ppm VME; 360 mg/m3 VME Germany: 100 ppm TWA; 370 mg/m3 TWA Japan: 100 ppm OEL; 360 mg/m3 OEL Malaysia: 100 ppm TWA; 361 mg/m3 TWA Netherlands: 100 ppm MAC; 360 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 100 ppm VLA-ED; 366 mg/m3 VLA-ED Spain: 125 ppm VLA-EC; 458 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Physical State: Liquid
Color: clear, colorless
Odor: none reported
pH: 5.2 (with buffer)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 96 - 97 deg C @ 8.30mm Hg
Freezing/Melting Point: 11 - 12 deg C
Autoignition Temperature: Not applicable.
Flash Point: 105 deg C ( 221.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.1800g/cm3
Molecular Formula: C6H10O5
Molecular Weight: 162.14

Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
Metals, strong oxidizing agents, reducing agents, acids, acid chlorides, aluminum, fluorine, magnesium, isocyanates, potassium, acetaldehyde, lithium, sodium, nitrides (e.g. potassium nitride, sodium nitride), acid anhydrides, calcium hypochlorite, dinitrogen tetraoxide, sodium + methanol, peroxomonosulfuric acid, potassium tert-butoxide, nitrobenzene, sodium nitrite, aluminum chloride, peroxydisulfuric acid, acetone + alkali, disilane, sodium methylate, triisopropylphosphine, sodium methoxide + methanol, hydrogen trisulfide, 1,3-butadiene, boron trifluoride diethyl ether.
Hazardous Decomposition Products:
Hydrogen chloride, phosgene, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, chlorine.
Hazardous Polymerization: Has not been reported.

RTECS#:
CAS# 67-66-3: FS9100000 CAS# 108-95-2: SJ3325000 CAS# 123-51-3: EL5425000 LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 148 mg; Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, mouse: LC50 = 17200 mg/m3/2H; Inhalation, mouse: LC50 = 6000 mg/m3/6H; Inhalation, rat: LC50 = 47702 mg/m3/4H; Inhalation, rat: LC50 = 6000 mg/m3/6H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg; Oral, rat: LD50 = 1250 mg/kg; Skin, rabbit: LD50 = >20 gm/kg.
CAS# 108-95-2: Draize test, rabbit, eye: 5 mg Severe; Draize test, rabbit, skin: 500 mg/24H Severe; Draize test, rabbit, skin: 100 mg Mild; Inhalation, mouse: LC50 = 177 mg/m3; Inhalation, mouse: LC50 = 177 mg/m3/4H; Inhalation, rat: LC50 = 316 mg/m3; Inhalation, rat: LC50 = 316 mg/m3/4H; Oral, mouse: LD50 = 270 mg/kg; Oral, rat: LD50 = 317 mg/kg; Oral, rat: LD50 = 512 mg/kg; Skin, rabbit: LD50 = 630 mg/kg; Skin, rat: LD50 = 669 mg/kg; Skin, rat: LD50 = 1500 mg/kg.
CAS# 123-51-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Oral, rabbit: LD50 = 3438 mg/kg; Oral, rat: LD50 = 1300 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = 3970 uL/kg.
Carcinogenicity:
Chloroform - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 10/1/87 NTP: Suspect carcinogen IARC: Group 2B carcinogen Phenol - Not listed by ACGIH, IARC, or NTP.
Isoamyl alcohol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Ecotoxicity:
Water flea Daphnia: EC50=12 mg/l; 48-hour; CAS# 108-95-2: UnspecifiedWater flea Daphnia: EC50=4.0 mg/l; 96-hour; CAS# 108-95-2: UnspecifiedFish: Fathead Minnow: LC50 > 50 mg/l; 1 Hr; CAS# 108-95-2 Static @ 18-22CFish: Fathead Minnow: TLm = 41 mg/L; 48-hour; CAS# 108-95-2: Flow-through @ 15CFish: Bluegill/Sunfish: TLm = 19 / 5.7 mg/L; 96 Hr; CAS# 108-95-2: Flow-throughIf released to the environment, phenols primary removal mechanism is biodegradation which is generally rapid (days). If phenol is released to soil, it will readily leach and biodegrade. The biodegradation in soil is generally rapid with half-lives of under 5 days even in subsurface

Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 67-66-3: 10 lb final RQ; 4.54 kg final RQ
USA RQ: CAS# 108-95-2: 1000 lb final RQ; 454 kg final RQ

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T C
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 34 Causes burns.
R 48/20/21/22 Harmful : danger of serious damage to
health by prolonged exposure through inhalation, in
contact with skin and if swallowed.
R 68 Possible risk of irreversible effects.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28 After contact with skin, wash immediately
with...
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 67-66-3: 3
CAS# 108-95-2: 2
CAS# 123-51-3: 1
Canada
CAS# 67-66-3 is listed on Canadas DSL List.
CAS# 108-95-2 is listed on Canadas DSL List.
CAS# 123-51-3 is listed on Canadas DSL List.
CAS# 67-66-3 is listed on Canadas Ingredient Disclosure List.
CAS# 108-95-2 is listed on Canadas Ingredient Disclosure List.
CAS# 123-51-3 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-66-3 is listed on the TSCA inventory.
CAS# 108-95-2 is listed on the TSCA inventory.
CAS# 123-51-3 is listed on the TSCA inventory.