MSDS Name:Phorbol 12-myristate 13-acetate
Synonym:Myristic acid, 9-ester with alpha,1b-beta,4,4a,7a-alpha,7b,8,9,9a-decahydro-4a-b ta, 7b-alpha,9-beta,9a-alpha-tetrahydroxy-3-(hydroxymethyl)-1 1,6,8-alpha-tetr amethyl-5H- cyclopropa(3,4)benz(1,2-e)azulen-5-one, 9a-acetate; Phorbol acetate

EMERGENCY OVERVIEW
Irritating to skin.The toxicological properties of this material have not been fully investigated.Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May cause blood platlet aggregation.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
May cause fetal effects. Laboratory experiments have resulted in mutagenic effects. Animal studies have reported the development of tumors.

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.
Use dry chemical, carbon dioxide, or halon extinguisher.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Pick up wash liquid with additional absorbent and place into a suitable disposable container. Wash area with soap and water. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation. Inactivate spilled material with 5% sodium hypochlorite.

Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.
Storage:
Store in a tightly closed container. Keep under a nitrogen blanket.
Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20C). Store protected from light.

Engineering Controls:
Use only under a chemical fume hood.
Exposure Limits CAS# 16561-29-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Physical State: Crystals
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 72 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Negligible.
Specific Gravity/Density:
Molecular Formula: C36H56O8
Molecular Weight: 616.3872

Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, acids, alkalies.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

RTECS#:
CAS# 16561-29-8: QH4377000 LD50/LC50:
Not available.
Carcinogenicity:
Phorbol 12-myristate 13-acetate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 38 Irritating to skin.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/39 Wear suitable protective clothing and
eye/face protection.
WGK (Water Danger/Protection)
CAS# 16561-29-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 16561-29-8 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 16561-29-8 is not listed on the TSCA inventory.
It is for research and development use only.