MSDS Name:Piperidine 20% in N-methylpyrrolidone peptide synthesis
Synonym:

EMERGENCY OVERVIEW
Highly flammable. Toxic by inhalation and in contact with skin.
Causes burns. Irritating to eyes and skin.
Potential Health Effects
Eye:
Causes eye irritation. Causes eye burns.
Skin:
Causes skin irritation. Causes skin burns. Toxic in contact with skin.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract. Toxic if inhaled.
Chronic:
Not available.

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.

Handling:
Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Flammables-area.

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 110-89-4: United Kingdom, WEL - TWA: 1 ppm TWA; 3.5 mg/m3 TWA United Kingdom, WEL - STEL: 3 ppm STEL; 10.5 mg/m3 STEL Russia: 0.2 mg/m3 TWA CAS# 872-50-4: United Kingdom, WEL - TWA: 25 ppm TWA; 103 mg/m3 TWA United Kingdom, WEL - STEL: 75 ppm STEL; 309 mg/m3 STEL Germany: 19 ppm TWA (steam); 80 mg/m3 TWA (steam) Germany: Skin absorber Japan: 1 ppm OEL; 4 mg/m3 OEL Netherlands: 20 ppm MAC; 80 mg/m3 MAC (fume) Russia: 100 mg/m3 TWA Spain: 25 ppm VLA-ED; 103 mg/m3 VLA-ED Spain: 75 ppm VLA-EC; 309 mg/m3 VLA-EC Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 16 deg C ( 60.80 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:

Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

RTECS#:
CAS# 110-89-4: TM3500000 CAS# 872-50-4: UY5790000 LD50/LC50:
CAS# 110-89-4: Draize test, rabbit, eye: 250 ug/24H Severe; Draize test, rabbit, skin: 5 mg/24H Severe; Inhalation, mouse: LC50 = 6000 mg/m3/2H; Oral, mouse: LD50 = 30 mg/kg; Oral, rabbit: LD50 = 145 mg/kg; Oral, rat: LD50 = 400 mg/kg; Skin, rabbit: LD50 = 276 mg/kg.
CAS# 872-50-4: Draize test, rabbit, eye: 100 mg Moderate; Oral, mouse: LD50 = 5130 mg/kg; Oral, rat: LD50 = 3914 mg/kg; Skin, rabbit: LD50 = 8 gm/kg.
Carcinogenicity:
Piperidine - Not listed by ACGIH, IARC, or NTP.
N-Methylpyrrolidone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Dispose of in a manner consistent with federal, state, and local regulations.

IATA
Shipping Name: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S.*
Hazard Class: 8
UN Number: 3267
Packing Group: II
IMO
Shipping Name: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S.
Hazard Class: 8
UN Number: 3267
Packing Group: II
RID/ADR
No information available.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 23/24 Toxic by inhalation and in contact with
skin.
R 34 Causes burns.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 27 Take off immediately all contaminated clothing.
S 41 In case of fire and/or explosion do not breathe
fumes.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 110-89-4: 1
CAS# 872-50-4: 1
Canada
CAS# 110-89-4 is listed on Canadas DSL List.
CAS# 872-50-4 is listed on Canadas DSL List.
CAS# 110-89-4 is not listed on Canadas Ingredient Disclosure List.
CAS# 872-50-4 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-89-4 is listed on the TSCA inventory.
CAS# 872-50-4 is listed on the TSCA inventory.