Name:
Propylene glycol
Synonym:
1,2-Dihydroxypropane; Methylethylene glycol; Monopropylene glycol; 1,2-Propylene glycol; 1,2-Propanediol; 2-Hydroxypropanol
CAS:
57-55-6
Section 1 - Chemical Product
MSDS Name:Propylene glycol
Synonym:1,2-Dihydroxypropane; Methylethylene glycol; Monopropylene glycol; 1,2-Propylene glycol; 1,2-Propanediol; 2-Hydroxypropanol
Synonym:1,2-Dihydroxypropane; Methylethylene glycol; Monopropylene glycol; 1,2-Propylene glycol; 1,2-Propanediol; 2-Hydroxypropanol
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 57-55-6 | Propylene glycol | 100 | 200-338-0 |
| Hazard Symbols: None Listed. Risk Phrases: None Listed. |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
May cause slight transient injury.
Skin:
May be absorbed through damaged or abraded skin in harmful amounts.
Allergic reactions have been reported. A single prolonged skin exposure is not likely to result in the material being absorbed in harmful amounts. Prolonged contact is essentially non-irritating to skin. Repeated exposures may cause problems.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling. May cause hemoglobinuric nephrosis. May cause changes in surface EEG.
Inhalation:
Low hazard for usual industrial handling. May cause respiratory tract irritation. Inhalation of a mist of this material may cause respiratory tract irritation. Material has a low vapor pressure, so exposure to vapor is not likely.
Chronic:
Exposure to large doses may cause central nervous system depression.
Chronic ingestion may cause lactic acidosis and possible seizures.
Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Birth defects are unlikely. In animal studies, propylene glycol has been shown not to interfere with reproduction.
Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
May cause slight transient injury.
Skin:
May be absorbed through damaged or abraded skin in harmful amounts.
Allergic reactions have been reported. A single prolonged skin exposure is not likely to result in the material being absorbed in harmful amounts. Prolonged contact is essentially non-irritating to skin. Repeated exposures may cause problems.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling. May cause hemoglobinuric nephrosis. May cause changes in surface EEG.
Inhalation:
Low hazard for usual industrial handling. May cause respiratory tract irritation. Inhalation of a mist of this material may cause respiratory tract irritation. Material has a low vapor pressure, so exposure to vapor is not likely.
Chronic:
Exposure to large doses may cause central nervous system depression.
Chronic ingestion may cause lactic acidosis and possible seizures.
Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Birth defects are unlikely. In animal studies, propylene glycol has been shown not to interfere with reproduction.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Persons with impaired kidney function may be more susceptible to the effects of this substance. Treat symptomatically and supportively.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Persons with impaired kidney function may be more susceptible to the effects of this substance. Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or alcohol-resistant foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 57-55-6: United Kingdom, WEL - TWA: 150 ppm TWA (total particulate and vapour); 474 mg/m3 TWA (total particulate and United Kingdom, WEL - STEL: 450 ppm STEL (total particulate and vapour); 1422 mg/m3 STEL (total particulate Russia: 7 mg/m3 TWA (particulates) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 57-55-6: United Kingdom, WEL - TWA: 150 ppm TWA (total particulate and vapour); 474 mg/m3 TWA (total particulate and United Kingdom, WEL - STEL: 450 ppm STEL (total particulate and vapour); 1422 mg/m3 STEL (total particulate Russia: 7 mg/m3 TWA (particulates) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless viscous
Odor: Odorless
pH: Not available.
Vapor Pressure: 0.08 mm Hg @ 20 deg C
Viscosity: 58.1 cps @ 20 deg C
Boiling Point: 187 deg C
Freezing/Melting Point: -60 deg C
Autoignition Temperature: 371 deg C ( 699.80 deg F)
Flash Point: 99 deg C ( 210.20 deg F)
Explosion Limits, lower: 2.6 vol %
Explosion Limits, upper: 12.6 vol %
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.0360 g/cm3
Molecular Formula: C3H8O2
Molecular Weight: 76.09
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid:
Excess heat, moist air.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, aldehydes.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.
Conditions to Avoid:
Excess heat, moist air.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, aldehydes.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 57-55-6: TY2000000 LD50/LC50:
CAS# 57-55-6: Draize test, rabbit, eye: 100 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Oral, mouse: LD50 = 22 gm/kg; Oral, mouse: LD50 = 20300 mg/kg; Oral, rabbit: LD50 = 18500 mg/kg; Oral, rat: LD50 = 20 gm/kg; Skin, rabbit: LD50 = 20800 mg/kg; Skin, rabbit: LD50 = 20800 mg/kg.
Carcinogenicity:
Propylene glycol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 57-55-6: TY2000000 LD50/LC50:
CAS# 57-55-6: Draize test, rabbit, eye: 100 mg Mild; Draize test, rabbit, eye: 500 mg/24H Mild; Oral, mouse: LD50 = 22 gm/kg; Oral, mouse: LD50 = 20300 mg/kg; Oral, rabbit: LD50 = 18500 mg/kg; Oral, rat: LD50 = 20 gm/kg; Skin, rabbit: LD50 = 20800 mg/kg; Skin, rabbit: LD50 = 20800 mg/kg.
Carcinogenicity:
Propylene glycol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Water flea Daphnia: EC50 > 10000 mg/L; 48 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 710 mg/L; 30 min; Microtox testFish: Goldfish: LC50 > 5000 mg/L; 24 Hr; UnspecifiedFish: Guppy: LC50 > 1000 mg/L; 48 Hr; UnspecifiedIf released to water, 1,2-propanediol is expected to degrade relatively rapidly via biodegradation. If released to soil, relatively rapid biodegradation should also occur. Significant leaching in soil can be predicted.
Water flea Daphnia: EC50 > 10000 mg/L; 48 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 710 mg/L; 30 min; Microtox testFish: Goldfish: LC50 > 5000 mg/L; 24 Hr; UnspecifiedFish: Guppy: LC50 > 1000 mg/L; 48 Hr; UnspecifiedIf released to water, 1,2-propanediol is expected to degrade relatively rapidly via biodegradation. If released to soil, relatively rapid biodegradation should also occur. Significant leaching in soil can be predicted.
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 57-55-6: 0
Canada
CAS# 57-55-6 is listed on Canadas DSL List.
CAS# 57-55-6 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 57-55-6 is listed on the TSCA inventory.
