Name:
Propylene oxide
Synonym:
Propane, 1,2-Epoxy-; 1,2-Ethoxypropane; 1,2-Propylene Oxide; Methyl Ethylene Oxide; Methyloxirane; 1,2-Epoxypropane
CAS:
75-56-9
Section 1 - Chemical Product
MSDS Name:Propylene oxide
Synonym:Propane, 1,2-Epoxy-; 1,2-Ethoxypropane; 1,2-Propylene Oxide; Methyl Ethylene Oxide; Methyloxirane; 1,2-Epoxypropane
Synonym:Propane, 1,2-Epoxy-; 1,2-Ethoxypropane; 1,2-Propylene Oxide; Methyl Ethylene Oxide; Methyloxirane; 1,2-Epoxypropane
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 75-56-9 |
| Hazard Symbols: T F+ Risk Phrases: |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Extremely flammable. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause cancer. May cause heritable genetic damage.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes severe skin irritation and possible burns. May lead to the formation of blisters.
Ingestion:
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Aspiration may cause respiratory swelling and pneumonitis. Vapors may cause dizziness or suffocation.
Chronic:
Prolonged inhalation may cause respiratory tract inflammation and lung damage. Prolonged or repeated skin contact may cause dermatitis. May cause cancer according to animal studies. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects.
Extremely flammable. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause cancer. May cause heritable genetic damage.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes severe skin irritation and possible burns. May lead to the formation of blisters.
Ingestion:
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Aspiration may cause respiratory swelling and pneumonitis. Vapors may cause dizziness or suffocation.
Chronic:
Prolonged inhalation may cause respiratory tract inflammation and lung damage. Prolonged or repeated skin contact may cause dermatitis. May cause cancer according to animal studies. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance. Treat symptomatically and supportively.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance. Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Extremely flammable. Material will readily ignite at room temperature. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Liquid will float and may reignite on the surface of water. May polymerize explosively when involved in a fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Extremely flammable. Material will readily ignite at room temperature. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Liquid will float and may reignite on the surface of water. May polymerize explosively when involved in a fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes.
Do not ingest or inhale. Prevent build up of vapors to explosive concentration. This product may be under pressure; cool before opening. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Do not get on skin or in eyes.
Do not ingest or inhale. Prevent build up of vapors to explosive concentration. This product may be under pressure; cool before opening. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHAs 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirators use.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless
Odor: alcohol-like - ethereal odor
pH: 7
Vapor Pressure: 400 mm Hg @ 17.8 deg C
Viscosity: 0.28 cP @ 25 deg C
Boiling Point: 34 deg C
Freezing/Melting Point: -112 deg C
Autoignition Temperature: 449 deg C ( 840.20 deg F)
Flash Point: -375 deg C ( -643.00 deg F)
Explosion Limits, lower: 2.3 vol %
Explosion Limits, upper: 36.0 vol %
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 0.8304 @ 20/20C
Molecular Formula: C3H6O
Molecular Weight: 58.0414
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. May polymerize.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Epoxy resin, sodium hydroxide, oxygen, ethylene oxide + polyhydric alcohol, ammonium hydroxide, chlorosulfonic acid, hydrochloric acid, hydrofluoric acid, nitric acid, oleum, sulfuric acid, oxidizing agents, copper, copper alloys, anhydrous metal chloride, iron, aluminum chloride, strong acids, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), peroxides, alkalis.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will occur.
Stable under normal temperatures and pressures. May polymerize.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Epoxy resin, sodium hydroxide, oxygen, ethylene oxide + polyhydric alcohol, ammonium hydroxide, chlorosulfonic acid, hydrochloric acid, hydrofluoric acid, nitric acid, oleum, sulfuric acid, oxidizing agents, copper, copper alloys, anhydrous metal chloride, iron, aluminum chloride, strong acids, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), peroxides, alkalis.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 75-56-9: TZ2975000 LD50/LC50:
Not available.
Carcinogenicity:
Propylene oxide - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
CAS# 75-56-9: TZ2975000 LD50/LC50:
Not available.
Carcinogenicity:
Propylene oxide - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Goldfish: LC50 = 170 mg/L; 24 Hr; UnspecifiedFish: Bluegill/Sunfish: TLm = 215 mg/L; 96 Hr; Static bioassay @ 24CIf released to soil, propylene oxide is expected to be susceptible to leaching and chemical hydrolysis in moist soils. It is expected to evaporate relatively rapidly from dry soil surfaces; evaporation from wet soils may also occur, but at a rate diminished by leaching.
If released to water, propylene oxide will hydrolyze. Volatilization of propylene oxide from the aquatic environment may be an important transport mechanism.
Fish: Goldfish: LC50 = 170 mg/L; 24 Hr; UnspecifiedFish: Bluegill/Sunfish: TLm = 215 mg/L; 96 Hr; Static bioassay @ 24CIf released to soil, propylene oxide is expected to be susceptible to leaching and chemical hydrolysis in moist soils. It is expected to evaporate relatively rapidly from dry soil surfaces; evaporation from wet soils may also occur, but at a rate diminished by leaching.
If released to water, propylene oxide will hydrolyze. Volatilization of propylene oxide from the aquatic environment may be an important transport mechanism.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing Group: I
IMO
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing Group: I
RID/ADR
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing group: I
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F+
Risk Phrases:
R 12 Extremely flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 75-56-9: 2
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 75-56-9 is not listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 75-56-9: OEL-AUSTRALIA:TWA 20 ppm (50 mg/m3);Carcinogen
OEL-BELGIUM:TWA 20 ppm (48 mg/m3)
OEL-DENMARK:TWA 5 ppm (12 mg/m3);Skin;Carcinogen
OEL-FINLAND:TWA 5 ppm (12 mg/m3);Carcinogen
OEL-FRANCE:TWA 20 ppm (50 mg/m3)
OEL-GERMANY;Carcinogen
OEL-THE NETHERLANDS:TWA 100 ppm (240 mg/m3)
OEL-THE PHILIPPINES:TWA 100 ppm (240 mg/m3)
OEL-RUSSIA:STEL 1 mg/m3;Skin
OEL-SWEDEN:TWA 5 ppm (12 mg/m3);STEL 10 ppm (25 mg/m3)
OEL-SWITZERLAND:TWA 2.5 ppm (6 mg/m3);Carcinogen
OEL-TURKEY:TWA 100 ppm (240 mg/m3)
OEL-UNITED KINGDOM:TWA 20 ppm (50 mg/m3);STEL 100 ppm
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 75-56-9 is not listed on the TSCA inventory.
It is for research and development use only.
