Name:
Pyridine reagent ACS
Synonym:
Azabenzene; Azine
CAS:
110-86-1
Section 1 - Chemical Product
MSDS Name:Pyridine reagent ACS
Synonym:Azabenzene; Azine
Synonym:Azabenzene; Azine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 110-86-1 | Pyridine | > 99 | 203-809-9 |
| Hazard Symbols: XN F Risk Phrases: 11 20/21/22 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation, in contact with skin and if swallowed.Stench.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin. Effects may be delayed. May cause smarting of the skin and first-degree burns on short exposure. Substance is readily absorbed through the skin. Pyridine was determined not to be a skin sensitizer in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause effects similar to those for inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation. Prolonged exposure may result in dizziness and general weakness. Other symptoms reported with acute exposure to pyridine include nervousness, insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt clinical symptoms can cause liver damage and repeated low-level exposures can cause cirrhosis. Feeding studies in rats produced blood effects like changes in clotting factors.
Highly flammable. Harmful by inhalation, in contact with skin and if swallowed.Stench.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin. Effects may be delayed. May cause smarting of the skin and first-degree burns on short exposure. Substance is readily absorbed through the skin. Pyridine was determined not to be a skin sensitizer in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause effects similar to those for inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation. Prolonged exposure may result in dizziness and general weakness. Other symptoms reported with acute exposure to pyridine include nervousness, insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt clinical symptoms can cause liver damage and repeated low-level exposures can cause cirrhosis. Feeding studies in rats produced blood effects like changes in clotting factors.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. Solid streams of water may be ineffective and spread material.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. Solid streams of water may be ineffective and spread material.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Prevent spreading of vapors through sewers, ventilation systems and confined areas. Evacuate unnecessary personnel. Approach spill from upwind.
U.S. regulations require reporting spills and releases to soil, water and air in excess of reportable quantities.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Prevent spreading of vapors through sewers, ventilation systems and confined areas. Evacuate unnecessary personnel. Approach spill from upwind.
U.S. regulations require reporting spills and releases to soil, water and air in excess of reportable quantities.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Isolate from oxidizing materials and acids.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Isolate from oxidizing materials and acids.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Personal Protective Equipment Eyes: Wear chemical goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Personal Protective Equipment Eyes: Wear chemical goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Appearance: colorless to light yellow
Odor: strong odor - fish-like
pH: 8.5 (0.2 M aq soln)
Vapor Pressure: 18 mm Hg @ 20 deg C
Viscosity: 0.95 mPa s 20 deg C
Boiling Point: 115 - 116.3 deg C
Freezing/Melting Point: -42 deg C
Autoignition Temperature: 900 deg F ( 482.22 deg C)
Flash Point: 17 deg C ( 62.60 deg F)
Explosion Limits, lower: 1.8%
Explosion Limits, upper: 12.4%
Decomposition Temperature: Not available.
Solubility in water: Miscible in water. Volatile in steam.
Specific Gravity/Density: .9700
Molecular Formula: C5H5N
Molecular Weight: 79.10
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, electrical sparks, exposure to flame.
Incompatibilities with Other Materials:
Acids; acid chlorides; oxidizing agents; chloroformates; bromine trifluoride; mixtures with formamide, iodine, and sulfur trioxide, chlorosulfonic acid, chromic acid, maleic anhydride, sulfuric acid, perchromates, and dinitrogen tetroxide Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, cyanide fumes.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, electrical sparks, exposure to flame.
Incompatibilities with Other Materials:
Acids; acid chlorides; oxidizing agents; chloroformates; bromine trifluoride; mixtures with formamide, iodine, and sulfur trioxide, chlorosulfonic acid, chromic acid, maleic anhydride, sulfuric acid, perchromates, and dinitrogen tetroxide Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, cyanide fumes.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 110-86-1: UR8400000 LD50/LC50:
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
Carcinogenicity:
Pyridine - IARC: Group 3 carcinogen Other:
See actual entry in RTECS for complete information.
CAS# 110-86-1: UR8400000 LD50/LC50:
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
Carcinogenicity:
Pyridine - IARC: Group 3 carcinogen Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: PYRIDINE
Hazard Class: 3
UN Number: 1282
Packing Group:
IMO
Shipping Name: PYRIDINE
Hazard Class: 3.2
UN Number: 1282
Packing Group:
RID/ADR
Shipping Name: PYRIDINE
Dangerous Goods Code: 3(3B)
UN Number: 1282
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
WGK (Water Danger/Protection)
CAS# 110-86-1: 2
United Kingdom Occupational Exposure Limits
CAS# 110-86-1: OES-United Kingdom, TWA 5 ppm TWA; 16 mg/m3 TWA
CAS# 110-86-1: OES-United Kingdom, STEL 10 ppm STEL; 33 mg/m3 STEL
Canada
CAS# 110-86-1 is listed on Canadas DSL List.
CAS# 110-86-1 is listed on Canadas Ingredient Disclosure List.
Exposure Limits
CAS# 110-86-1: OEL-ARAB Republic of Egypt:TWA 5 ppm (15 mg/m3)
OEL-AUSTRALIA:TWA 5 ppm (15 mg/m3)
OEL-BELGIUM:TWA 5 ppm (16 mg/m3)
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 10 mg/m3 JAN9
OEL-DENMARK:TWA 5 ppm (15 mg/m3)
OEL-FINLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin
OEL-FRANCE:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3)
OEL-GERMANY:TWA 5 ppm (15 mg/m3)
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin
OEL-THE NETHERLANDS:TWA 5 ppm (15 mg/m3)
OEL-THE PHILIPPINES:TWA 5 mg/m3
OEL-POLAND:TWA 5 mg/m3
OEL-RUSSIA:STEL 5 mg/m3
OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (35 mg/m3)
OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3)
OEL-TURKEY:TWA 5 ppm (15 mg/m3)
OEL-UNITED KINGDOM:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 110-86-1 is listed on the TSCA inventory.
